The Rho guanine dissociation inhibitor α inhibits skeletal muscle Rac1 activity and insulin action

Autor: Møller, Lisbeth L V, Ali, Mona Sadek, Davey, Jonathan, Raun, Steffen Henning, Andersen, Nicoline Resen, Long, Jonathan Z, Qian, Hongwei, Jeppesen, Jacob Fuglsbjerg, Henriquez-Olguin, Carlos, Frank, Emma, Jensen, Thomas Elbenhardt, Højlund, Kurt, Wojtaszewski, Jørgen, Nielsen, Joachim, Chiu, Tim T, Jedrychowski, Mark P, Gregorevic, Paul, Klip, Amira, Richter, Erik A., Sylow, Lykke

Publikováno v: Møller, L L V, Ali, M S, Davey, J, Raun, S H, Andersen, N R, Long, J Z, Qian, H, Jeppesen, J F, Henriquez-Olguin, C, Frank, E, Jensen, T E, Højlund, K, Wojtaszewski, J, Nielsen, J, Chiu, T T, Jedrychowski, M P, Gregorevic, P, Klip, A, Richter, E A & Sylow, L 2023, ' The Rho guanine dissociation inhibitor α inhibits skeletal muscle Rac1 activity and insulin action ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 27, e2211041120 . https://doi.org/10.1073/pnas.2211041120

The molecular events governing skeletal muscle glucose uptake have pharmacological potential for managing insulin resistance in conditions such as obesity, diabetes, and cancer. With no current pharmacological treatments to target skeletal muscle ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2751::b0df2f79cd63b91b1d29e4177681df50
https://curis.ku.dk/ws/files/358723573/Moller_et_al_PNAS_2023_Vol_120_27_e2211041120.pdf

APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice

Autor: Kenneth K.Y. Cheng, Gary Sweeney, Karen S.L. Lam, Yu Wang, Jialiang Zhang, Ruby L. C. Hoo, Donghai Wu, Aimin Xu

Publikováno v: Proceedings of the National Academy of Sciences. 109:8919-8924

Insulin resistance and defective insulin secretion are the two major features of type 2 diabetes. The adapter protein APPL1 is an obligatory molecule in regulating peripheral insulin sensitivity, but its role in insulin secretion remains elusive. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a7deeb6860d311b1a43394c57dce49
https://doi.org/10.1073/pnas.1202435109

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

Autor: Thomas W.H. Kay, Lut Overbergh, Dieter Rondas, Chantal Mathieu, Stacey Fynch, Jibran Ja Wali, Helen E. Thomas, Andreas Strasser, Mark D. McKenzie, Esteban Nicolas Gurzov, Yuxing Zhao, Shizuo Akira, Lorraine Elkerbout

Publikováno v: Cell death & disease, 5
Cell Death & Disease

Apoptosis of pancreatic beta cells is a feature of type 2 diabetes and its prevention may have therapeutic benefit. High glucose concentrations induce apoptosis of islet cells, and this requires the proapoptotic Bcl-2 homology domain 3 (BH3)-only pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de89d9a548d7de59388b8a4a9e4baac
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/260216

Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat

Autor: P.E. Morange, Alexis Jacquier, Anne Dutour, Marie-Christine Alessi, Frank Kober, Pierre-Julien Moro, Thomas Cuisset, S. Boullu, Monique Bernard, Karine Clément, F. Dadoun, Bénédicte Gaborit

Publikováno v: Int J Obes (Lond)
Int J Obes (Lond), 2012, 36 (3), pp.422-30. ⟨10.1038/ijo.2011.117⟩

Gaborit, B Kober, F Jacquier, A Moro, P J Cuisset, T Boullu, S Dadoun, F Alessi, M-C Morange, P Clement, K Bernard, M Dutour, A Comparative Study Research Support, Non-U.S. Gov't England International journal of obesity (2005) Int J Obes (Lond). 2012

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e7e2259a429a57d2e76277f9d7da0f
https://pubmed.ncbi.nlm.nih.gov/21730964

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Autor: Lara Allet, Stéphane Armand, Alain Golay, R. A. de Bie, Kamiar Aminian, J B Staal, Dominique Monnin, E. D. de Bruin

Publikováno v: Diabetologia, 53, 3, pp. 458-66
Diabetologia, 53, 458-66
Diabetologia, Vol. 53, No 3 (2010) pp. 458-466
Diabetologia, 53 (3)
Diabetologia
Diabetologia, 53(3), 458-466. Springer, Cham

Aims/hypothesis Gait characteristics and balance are altered in diabetic patients. Little is known about possible treatment strategies. This study evaluates the effect of a specific training programme on gait and balance of diabetic patients. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdab14edf0f9503d603aaa2558b3836
https://hdl.handle.net/2066/87828