Zobrazeno 1 - 10
of 614
pro vyhledávání: '"Tyndale, RF"'
Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects
Autor:
Faulkner, P, Ghahremani, DG, Tyndale, RF, Cox, CM, Kazanjian, AS, Paterson, N, Lotfipour, S, Hellemann, GS, Petersen, N, Vigil, C, London, ED
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 42, iss 8
Faulkner, P; Ghahremani, DG; Tyndale, RF; Cox, CM; Kazanjian, AS; Paterson, N; et al.(2017). Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects. Neuropsychopharmacology, 42(8), 1610-1618. doi: 10.1038/npp.2017.18. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0sg6s8bf
Faulkner, P; Ghahremani, DG; Tyndale, RF; Cox, CM; Kazanjian, AS; Paterson, N; et al.(2017). Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects. Neuropsychopharmacology, 42(8), 1610-1618. doi: 10.1038/npp.2017.18. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0sg6s8bf
© 2017 American College of Neuropsychopharmacology. All rights reserved. The use of cigarettes delivering different nicotine doses allows evaluation of the contribution of nicotine to the smoking experience. We compared responses of 46 young adult s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3a67ca66712eeb08f61d097012832c0a
https://escholarship.org/uc/item/0sg6s8bf
https://escholarship.org/uc/item/0sg6s8bf
Autor:
Ho, MK1, Tyndale, RF1 r.tyndale@utoronto.ca
Publikováno v:
Pharmacogenomics Journal. 2007, Vol. 7 Issue 2, p81-98. 18p.
Autor:
Lerman, C, Schnoll, RA, Hawk, LW, Cinciripini, P, George, TP, Wileyto, EP, Swan, GE, Benowitz, NL, Heitjan, DF, Tyndale, RF
Publikováno v:
Lerman, C; Schnoll, RA; Hawk, LW; Cinciripini, P; George, TP; Wileyto, EP; et al.(2015). Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: A randomised, double-blind placebo-controlled trial. The Lancet Respiratory Medicine, 3(2), 131-138. doi: 10.1016/S2213-2600(14)70294-2. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4hs4s0fx
© 2015 Elsevier Ltd. Background: Substantial variability exists in therapeutic response and adverse effects with pharmacotherapies for tobacco dependence. Biomarkers to optimise treatment choice for individual smokers might improve treatment outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::e798dbf97ba7d1d62c42a66f55112bda
http://www.escholarship.org/uc/item/4hs4s0fx
http://www.escholarship.org/uc/item/4hs4s0fx
Autor:
Tanner, JA, Novalen, M, Jatlow, P, Huestis, MA, Murphy, SE, Kaprio, J, Kankaanpää, A, Galanti, L, Stefan, C, George, TP, Benowitz, NL, Lerman, C, Tyndale, RF
Publikováno v:
Tanner, JA; Novalen, M; Jatlow, P; Huestis, MA; Murphy, SE; Kaprio, J; et al.(2015). Nicotine metabolite ratio (3-Hydroxycotinine/Cotinine) in plasma and urine by different analytical methods and laboratories: Implications for clinical implementation. Cancer Epidemiology Biomarkers and Prevention, 24(8), 1239-1246. doi: 10.1158/1055-9965.EPI-14-1381. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4tg1k9hb
© 2015 American Association for Cancer Research. Background: The highly genetically variable enzyme CYP2A6 metabolizes nicotine to cotinine (COT) and COT to trans-30- hydroxycotinine (3HC). The nicotine metabolite ratio (NMR, 3HC/COT) is commonly us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::4a7a14bcf2c52f5e5408917b2fca3e9d
http://www.escholarship.org/uc/item/4tg1k9hb
http://www.escholarship.org/uc/item/4tg1k9hb
Autor:
Benowitz, Neal, Zhu, AZX, Zhou, Q, Cox, LS, David, SP, Ahluwalia, JS, Benowitz, NL, Tyndale, RF
Publikováno v:
Benowitz, Neal; Zhu, AZX; Zhou, Q; Cox, LS; David, SP; Ahluwalia, JS; et al.(2014). Association of CHRNA5-A3-B4 SNP rs2036527 With Smoking Cessation Therapy Response in African-American Smokers. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5gv7d7nd
Associations between CHRNA5-A3-B4 variants and smoking behaviors exist; however, the association with smoking abstinence is less understood, particularly that among African Americans. In 1,295 African Americans enrolled in two clinical trials, we inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::e61f48b8c6646b3447f9e62bf1aec9f1
http://www.escholarship.org/uc/item/5gv7d7nd
http://www.escholarship.org/uc/item/5gv7d7nd
Publikováno v:
Zhu, AZX; Zhou, Q; Cox, LS; David, SP; Ahluwalia, JS; Benowitz, NL; et al.(2014). Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokers. Clinical Pharmacology and Therapeutics, 96(2), 256-265. doi: 10.1038/clpt.2014.88. UCSF: Retrieved from: http://www.escholarship.org/uc/item/78w8c34k
Associations between CHRNA5-A3-B4 variants and smoking behaviors exist; however, the association with smoking abstinence is less understood, particularly that among African Americans. In 1,295 African Americans enrolled in two clinical trials, we inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::d9ba4f69850d76a2783b3b6eb2ddb32a
http://www.escholarship.org/uc/item/78w8c34k
http://www.escholarship.org/uc/item/78w8c34k
Publikováno v:
Zhu, AZX; Zhou, Q; Cox, LS; Ahluwalia, JS; Benowitz, NL; & Tyndale, RF. (2014). Gene variants in CYP2C19 are associated with altered in vivo bupropion pharmacokinetics but not bupropion-assisted smoking cessation outcomes. Drug Metabolism and Disposition, 42(11), 1971-1977. doi: 10.1124/dmd.114.060285. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6qm655sb
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics. Bupropion is used clinically to treat depression and to promote smoking cessation. It is metabolized by CYP2B6 to its active metabolite hydroxybupropion, yet al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::b4bd7e41b80eb5a67a7d4f4fff163a40
http://www.escholarship.org/uc/item/6qm655sb
http://www.escholarship.org/uc/item/6qm655sb
Publikováno v:
Benowitz, Neal; Dempsey, Delia; Dempsey, DA; St, G; Jacob, P; Tyndale, RF; et al.(2013). Genetic and pharmacokinetic determinants of response to transdermal nicotine in white, black, and Asian nonsmokers. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5p23v8rd
The aim of the study was to examine genetic, pharmacokinetic, and demographic factors that influence sensitivity to nicotine in never-smokers. Sixty never-smokers, balanced for gender and race (white, black, and Asian), wore 7-mg nicotine skin patche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::97f8c97e32f7681de1b8387606ae5711
http://www.escholarship.org/uc/item/5p23v8rd
http://www.escholarship.org/uc/item/5p23v8rd
Autor:
David, SP, Strong, DR, Leventhal, AM, Lancaster, MA, Mcgeary, JE, Munafò, MR, Bergen, AW, Swan, GE, Benowitz, NL, Tyndale, RF, Conti, DV, Brown, RA, Lerman, C, Niaura, R
Publikováno v:
David, SP; Strong, DR; Leventhal, AM; Lancaster, MA; Mcgeary, JE; Munafò, MR; et al.(2013). Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: Results from two randomized clinical trials of bupropion. Addiction, 108(12), 2202-2211. doi: 10.1111/add.12325. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/4r33t24b
Aims: To evaluate the associations of treatment and an additive genetic efficacy score (AGES) based on dopamine functional polymorphisms with time to first smoking lapse and point prevalence abstinence at end of treatment among participants enrolled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::9e76ea3e3753c62dc59265b9c0d78868
http://www.escholarship.org/uc/item/4r33t24b
http://www.escholarship.org/uc/item/4r33t24b
Publikováno v:
Zhu, AZX; Renner, CC; Hatsukami, DK; Benowitz, NL; & Tyndale, RF. (2013). CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in alaska native tobacco users. Addiction, 108(10), 1818-1828. doi: 10.1111/add.12250. UCSF: Retrieved from: http://www.escholarship.org/uc/item/5bj1k53q
Background and aims: Gene variants in CHRNA5-A3-B4, which encode for the α5, α3 and β4 nicotinic receptor subunits, are associated with altered smoking behaviors in European Americans. Little is known about CHRNA5-A3-B4 and its association with sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::6ef1d21a574e6729ee6f35009de5d396
http://www.escholarship.org/uc/item/5bj1k53q
http://www.escholarship.org/uc/item/5bj1k53q