Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Tylor R Lewis"'
Autor:
Tylor R Lewis, Mustafa S Makia, Carson M Castillo, Ying Hao, Muayyad R Al-Ubaidi, Nikolai P Skiba, Shannon M Conley, Vadim Y Arshavsky, Muna I Naash
Publikováno v:
eLife, Vol 12 (2023)
Visual signal transduction takes place within a stack of flattened membranous ‘discs’ enclosed within the light-sensitive photoreceptor outer segment. The highly curved rims of these discs, formed in the process of disc enclosure, are fortified b
Externí odkaz:
https://doaj.org/article/f1a6b2b27aea469492cc14481ac299ac
Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure
Autor:
Tylor R Lewis, Sebastien Phan, Carson M Castillo, Keun-Young Kim, Kelsey Coppenrath, William Thomas, Ying Hao, Nikolai P Skiba, Marko E Horb, Mark H Ellisman, Vadim Y Arshavsky
Publikováno v:
eLife, Vol 12 (2023)
The first steps of vision take place within a stack of tightly packed disc-shaped membranes, or ‘discs’, located in the outer segment compartment of photoreceptor cells. In rod photoreceptors, discs are enclosed inside the outer segment and conta
Externí odkaz:
https://doaj.org/article/17510d5e06c648109d8f8feee4457282
Autor:
George Khelashvili, Anoop Narayana Pillai, Joon Lee, Kalpana Pandey, Alexander M. Payne, Zarek Siegel, Michel A. Cuendet, Tylor R. Lewis, Vadim Y. Arshavsky, Johannes Broichhagen, Joshua Levitz, Anant K. Menon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Mutations in the G protein-coupled receptor (GPCR) rhodopsin are a common cause of autosomal dominant retinitis pigmentosa, a blinding disease. Rhodopsin self-associates in the membrane, and the purified monomeric apo-protein opsin dimerizes
Externí odkaz:
https://doaj.org/article/dd6f556860b34a2ea32087d0f5c5847f
Autor:
Rupalatha Maddala, Junyuan Gao, Richard T. Mathias, Tylor R. Lewis, Vadim Y. Arshavsky, Adriana Levine, Jonathan M. Backer, Anne R. Bresnick, Ponugoti V. Rao
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract S100A4, a member of the S100 family of multifunctional calcium-binding proteins, participates in several physiological and pathological processes. In this study, we demonstrate that S100A4 expression is robustly induced in differentiating fi
Externí odkaz:
https://doaj.org/article/c5d12a9b1ee845928e568c3467712a88
Autor:
Tylor R. Lewis, Mustafa S. Makia, Mashal Kakakhel, Muayyad R. Al-Ubaidi, Vadim Y. Arshavsky, Muna I. Naash
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Mutations in the peripherin-2 gene (PRPH2, also known as rds) cause a heterogeneous range of autosomal dominant retinal diseases. PRPH2 encodes a photoreceptor-specific tetraspanin protein, PRPH2, that is a main structural component of the photorecep
Externí odkaz:
https://doaj.org/article/fad4f9571f02471eb309de69d773d5fb
Publikováno v:
BMC Cell Biology, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background KIF17, a kinesin-2 motor that functions in intraflagellar transport, can regulate the onset of photoreceptor outer segment development. However, the function of KIF17 in a mature photoreceptor remains unclear. Additionally, the ci
Externí odkaz:
https://doaj.org/article/7142f103a74a4ae0922c15d46a52dee0
Publikováno v:
PAIN Reports, Vol 4, Iss 4, p e765 (2019)
Abstract. Introduction:. Many patients with sickle cell disease (SCD) suffer from chronic pain, which is often described as neuropathic in nature. Although vascular and inflammatory pathology undoubtedly contribute to the SCD pain experience, the noc
Externí odkaz:
https://doaj.org/article/c3ea94ffc3b742fcaf18a239296b18ec
Autor:
Christopher C. Pan, Raquel Maeso-Díaz, Tylor R. Lewis, Kun Xiang, Lianmei Tan, Yaosi Liang, Liuyang Wang, Fengrui Yang, Tao Yin, Calvin Wang, Kuo Du, De Huang, Seh Hoon Oh, Ergang Wang, Bryan Jian Wei Lim, Mengyang Chong, Peter B. Alexander, Xuebiao Yao, Vadim Y. Arshavsky, Qi-Jing Li, Anna Mae Diehl, Xiao-Fan Wang
Publikováno v:
Cell Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc090672c1f2f2ddfcd6a5ee028d4ee
https://doi.org/10.1038/s41422-023-00820-4
https://doi.org/10.1038/s41422-023-00820-4
Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure
Autor:
Tylor R. Lewis, Sebastien Phan, Carson M. Castillo, Keun-Young Kim, Kelsey Coppenrath, William Thomas, Ying Hao, Nikolai P. Skiba, Marko E. Horb, Mark H. Ellisman, Vadim Y. Arshavsky
The first steps of vision take place within a stack of tightly packed disc-shaped membranes, or “discs”, located in the outer segment compartment of photoreceptor cells. In rod photoreceptors, discs are enclosed inside the outer segment and conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b3dc767f2b30e6ab4c6d30f58e458eb
https://doi.org/10.1101/2023.04.06.535932
https://doi.org/10.1101/2023.04.06.535932
Autor:
William J. Spencer, Nicholas F. Schneider, Tylor R. Lewis, Carson M. Castillo, Nikolai P. Skiba, Vadim Y. Arshavsky
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The photoreceptor outer segment is a modified cilium filled with hundreds of flattened “disc” membranes responsible for efficient light capture. To maintain photoreceptor health and functionality, outer segments are continuously renewed through t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97d6118a4a695d84926d3075f4869077
https://doi.org/10.1073/pnas.2215011120
https://doi.org/10.1073/pnas.2215011120