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Autor:
Hernando Leon, Grzegorz Sawicki, Tyler van Mulligen, Adrian C. Nicolescu, Andrew Holt, Bryan D. Crawford, Serena Viappiani, Richard Schulz
Publikováno v:
Biochemical Pharmacology. 77:826-834
Matrix metalloproteinase-2 (MMP-2) has emerged as a key protease in various pathologies associated with oxidative stress, including myocardial ischemia-reperfusion, heart failure or inflammation. Peroxynitrite (ONOO(-)), an important effector of oxid