Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Tyler Stephens"'
Autor:
Rong Sylvie Yang, Maria Traver, Nathan Barefoot, Tyler Stephens, Casper Alabanza, Javier Manzella-Lapeira, Guozhang Zou, Jeremy Wolff, Yile Li, Melissa Resto, William Shadrick, Yanhong Yang, Vera B. Ivleva, Yaroslav Tsybovsky, Kevin Carlton, Joseph Brzostowski, Jason G. Gall, Q. Paula Lei
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Recent work by our laboratory and others indicates that co-display of multiple antigens on protein-based nanoparticles may be key to induce cross-reactive antibodies that provide broad protection against disease. To reach the ultimate goal o
Externí odkaz:
https://doaj.org/article/056f89178cb84dcfae41f8f400a31834
Autor:
Jianliang Xu, Tongqing Zhou, Krisha McKee, Baoshan Zhang, Cuiping Liu, Alexandra F. Nazzari, Amarendra Pegu, Chen‐Hsiang Shen, Jordan E. Becker, Michael F. Bender, Payton Chan, Anita Changela, Ridhi Chaudhary, Xuejun Chen, Tal Einav, Young Do Kwon, Bob C. Lin, Mark K. Louder, Jonah S. Merriam, Nicholas C. Morano, Sijy O'Dell, Adam S. Olia, Reda Rawi, Ryan S. Roark, Tyler Stephens, I‐Ting Teng, Emily Tourtellott‐Fogt, Shuishu Wang, Eun Sung Yang, Lawrence Shapiro, Yaroslav Tsybovsky, Nicole A. Doria‐Rose, Rafael Casellas, Peter D. Kwong
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Broadly neutralizing antibodies are proposed as therapeutic and prophylactic agents against HIV‐1, but their potency and breadth are less than optimal. This study describes the immunization of a llama with the prefusion‐stabilized HIV‐
Externí odkaz:
https://doaj.org/article/2af27b428ce0453586e0f60b99fd2446
Autor:
Jason Gorman, Crystal Sao-Fong Cheung, Zhijian Duan, Li Ou, Maple Wang, Xuejun Chen, Cheng Cheng, Andrea Biju, Yaping Sun, Pengfei Wang, Yongping Yang, Baoshan Zhang, Jeffrey C. Boyington, Tatsiana Bylund, Sam Charaf, Steven J. Chen, Haijuan Du, Amy R. Henry, Tracy Liu, Edward K. Sarfo, Chaim A. Schramm, Chen-Hsiang Shen, Tyler Stephens, I-Ting Teng, John-Paul Todd, Yaroslav Tsybovsky, Raffaello Verardi, Danyi Wang, Shuishu Wang, Zhantong Wang, Cheng-Yan Zheng, Tongqing Zhou, Daniel C. Douek, John R. Mascola, David D. Ho, Mitchell Ho, Peter D. Kwong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Lassa virus (LASV) infection is expanding outside its traditionally endemic areas in West Africa, posing a pandemic biothreat. LASV-neutralizing antibodies, moreover, have proven difficult to elicit. To gain insight into LASV neutralization,
Externí odkaz:
https://doaj.org/article/83f13599c74f445ebfcd24f0985fef96
Autor:
Cuiping Liu, Lingshu Wang, Jonah S. Merriam, Wei Shi, Eun Sung Yang, Yi Zhang, Man Chen, Wing-Pui Kong, Cheng Cheng, Yaroslav Tsybovsky, Tyler Stephens, Raffaello Verardi, Kwanyee Leung, Cody Stein, Adam S. Olia, Darcy R. Harris, Misook Choe, Baoshan Zhang, Barney S. Graham, Peter D. Kwong, Richard A. Koup, Amarendra Pegu, John R. Mascola
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract While several COVID-19 vaccines have been in use, more effective and durable vaccines are needed to combat the ongoing COVID-19 pandemic. Here, we report highly immunogenic self-assembling SARS-CoV-2 spike-HBsAg nanoparticles displaying a si
Externí odkaz:
https://doaj.org/article/9b37253d44914adeb9ec845f4062bcd4
Autor:
Adam S. Olia, Cheng Cheng, Tongqing Zhou, Andrea Biju, Darcy R. Harris, Anita Changela, Hongying Duan, Vera B. Ivleva, Wing-Pui Kong, Li Ou, Reda Rawi, Yaroslav Tsybovsky, David J. Van Wazer, Angela R. Corrigan, Christopher A. Gonelli, Myungjin Lee, Krisha McKee, Sandeep Narpala, Sijy O’Dell, Danealle K. Parchment, Erik-Stephane D. Stancofski, Tyler Stephens, Ivy Tan, I-Ting Teng, Shuishu Wang, Qing Wei, Yongping Yang, Zhengrong Yang, Baoshan Zhang, Jan Novak, Matthew B. Renfrow, Nicole A. Doria-Rose, Richard A. Koup, Adrian B. McDermott, Jason G. Gall, Q. Paula Lei, John R. Mascola, Peter D. Kwong
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107403- (2023)
Summary: Soluble HIV-1-envelope (Env) trimers elicit immune responses that target their solvent-exposed protein bases, the result of removing these trimers from their native membrane-bound context. To assess whether glycosylation could limit these ba
Externí odkaz:
https://doaj.org/article/f61151545f45450b8eb0961391496066
Autor:
Shuishu Wang, Flavio Matassoli, Baoshan Zhang, Tracy Liu, Chen-Hsiang Shen, Tatsiana Bylund, Timothy Johnston, Amy R. Henry, I-Ting Teng, Prabhanshu Tripathi, Jordan E. Becker, Anita Changela, Ridhi Chaudhary, Cheng Cheng, Martin Gaudinski, Jason Gorman, Darcy R. Harris, Myungjin Lee, Nicholas C. Morano, Laura Novik, Sijy O’Dell, Adam S. Olia, Danealle K. Parchment, Reda Rawi, Jesmine Roberts-Torres, Tyler Stephens, Yaroslav Tsybovsky, Danyi Wang, David J. Van Wazer, Tongqing Zhou, Nicole A. Doria-Rose, Richard A. Koup, Lawrence Shapiro, Daniel C. Douek, Adrian B. McDermott, Peter D. Kwong
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112755- (2023)
Summary: Elicitation of antibodies that neutralize the tier-2 neutralization-resistant isolates that typify HIV-1 transmission has been a long-sought goal. Success with prefusion-stabilized envelope trimers eliciting autologous neutralizing antibodie
Externí odkaz:
https://doaj.org/article/bb8a5ffea19d425c87466117bf7a3b5c
Autor:
Daniel Ellis, Julia Lederhofer, Oliver J. Acton, Yaroslav Tsybovsky, Sally Kephart, Christina Yap, Rebecca A. Gillespie, Adrian Creanga, Audrey Olshefsky, Tyler Stephens, Deleah Pettie, Michael Murphy, Claire Sydeman, Maggie Ahlrichs, Sidney Chan, Andrew J. Borst, Young-Jun Park, Kelly K. Lee, Barney S. Graham, David Veesler, Neil P. King, Masaru Kanekiyo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Influenza virus neuraminidase (NA) is a drug target and a potential vaccine antigen. Here, the authors provide a detailed analysis of the conformational stability of NA, and show how expression and stability of recombinant NA antigens can be strength
Externí odkaz:
https://doaj.org/article/e57f3c320a9b4bb08e43192a409483e7
Autor:
Yongping Yang, Wing-Pui Kong, Cuiping Liu, Tracy J. Ruckwardt, Yaroslav Tsybovsky, Lingshu Wang, Shuishu Wang, Daniel W. Biner, Man Chen, Tracy Liu, Jonah Merriam, Adam S. Olia, Li Ou, Qi Qiu, Wei Shi, Tyler Stephens, Eun Sung Yang, Baoshan Zhang, Yi Zhang, Qiong Zhou, Reda Rawi, Richard A. Koup, John R. Mascola, Peter D. Kwong
Publikováno v:
Vaccines, Vol 11, Iss 9, p 1438 (2023)
New vaccine delivery technologies, such as mRNA, have played a critical role in the rapid and efficient control of SARS-CoV-2, helping to end the COVID-19 pandemic. Enveloped virus-like particles (eVLPs) are often more immunogenic than protein subuni
Externí odkaz:
https://doaj.org/article/8ab93849e5894e8c9f76f1f20c883425
Autor:
Kai Xu, Yiran Wang, Chen-Hsiang Shen, Yiwei Chen, Baoshan Zhang, Kevin Liu, Yaroslav Tsybovsky, Shuishu Wang, S. Katie Farney, Jason Gorman, Tyler Stephens, Raffaello Verardi, Yongping Yang, Tongqing Zhou, Gwo-Yu Chuang, Antonio Lanzavecchia, Luca Piccoli, Peter D. Kwong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
RIFINs are Plasmodium surface antigens that suppress the immune response by binding inhibitory receptors such as LAIR1. Here, Xu et al. characterize the interaction between RIFIN-variable 2 domain and a LAIR1 domain and identify LAIR1-binding RIFINs
Externí odkaz:
https://doaj.org/article/40cd63ae784a4e7da4dd3cda05cd7474
Autor:
Adrian Creanga, Rebecca A. Gillespie, Brian E. Fisher, Sarah F. Andrews, Julia Lederhofer, Christina Yap, Liam Hatch, Tyler Stephens, Yaroslav Tsybovsky, Michelle C. Crank, Julie E. Ledgerwood, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Masaru Kanekiyo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Understanding the human antibody response to influenza A virus strains is important for vaccine development. Here, Creanga et al. generate a panel of 55 replication-deficient reporter viruses representing diversity of human H1N1 and H3N2, and pandemi
Externí odkaz:
https://doaj.org/article/f356614b040e47ff842a80b70937a8bb