Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tyler Sniegowski"'
Autor:
Tyler Sniegowski, Devaraja Rajasekaran, Souad R. Sennoune, Sukumaran Sunitha, Fang Chen, Mohamed Fokar, Sudhir Kshirsagar, P. Hemachandra Reddy, Ksenija Korac, Mosharaf Mahmud Syed, Tanima Sharker, Vadivel Ganapathy, Yangzom D. Bhutia
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) cells have a great demand for nutrients in the form of sugars, amino acids, and lipids. Particularly, amino acids are critical for cancer growth and, as intermediates, connect glucose, lipid and nucleo
Externí odkaz:
https://doaj.org/article/8da0a1c1200e43b09d36b442c5a114e9
Autor:
Rachel L. Washburn, Dalia Martinez-Marin, Tyler Sniegowski, Ksenija Korać, Alexis R. Rodriguez, Jonathan M. Miranda, Beverly S. Chilton, Robert K. Bright, Kevin Pruitt, Yangzom D. Bhutia, Jannette M. Dufour
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1650 (2023)
Transplantation is a clinical procedure that treats a variety of diseases yet is unattainable for many patients due to a nationwide organ shortage and the harsh side effects of chronic immune suppression. Xenografted pig organs are an attractive alte
Externí odkaz:
https://doaj.org/article/b54c88465c0646c0ae6edfd99d7c02ae
Autor:
Rachel L. Washburn, Dalia Martinez-Marin, Ksenija Korać, Tyler Sniegowski, Alexis R. Rodriguez, Beverly S. Chilton, Taylor Hibler, Kevin Pruitt, Yangzom D. Bhutia, Jannette M. Dufour
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 1890 (2023)
The complement system is an important component of transplant rejection. Sertoli cells, an immune regulatory testicular cell, survive long-term when transplanted across immunological barriers; thus, understanding the mechanisms behind this unique sur
Externí odkaz:
https://doaj.org/article/02ddee60c450489a9b7686383e484217
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 216 (2021)
The glutaminolysis and serine–glycine–one-carbon pathways represent metabolic reactions that are reprogramed and upregulated in cancer; these pathways are involved in supporting the growth and proliferation of cancer cells. Glutaminolysis partici
Externí odkaz:
https://doaj.org/article/725d0d05fe9b460a8e91b59cf07aff2e
Autor:
Dufour, Rachel L. Washburn, Dalia Martinez-Marin, Tyler Sniegowski, Ksenija Korać, Alexis R. Rodriguez, Jonathan M. Miranda, Beverly S. Chilton, Robert K. Bright, Kevin Pruitt, Yangzom D. Bhutia, Jannette M.
Publikováno v:
Biomedicines; Volume 11; Issue 6; Pages: 1650
Transplantation is a clinical procedure that treats a variety of diseases yet is unattainable for many patients due to a nationwide organ shortage and the harsh side effects of chronic immune suppression. Xenografted pig organs are an attractive alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::23533812746dbf1ca20d68f331b3a6e7
Autor:
Bradley K. Schniers, Mitchell S. Wachtel, Meenu Sharma, Ksenija Korac, Devaraja Rajasekaran, Shengping Yang, Tyler Sniegowski, Vadivel Ganapathy, Yangzom D. Bhutia
Publikováno v:
Biochemical Journal. 479:719-730
Pancreatic ductal adenocarcinoma (PDAC) is lethal. There is a dire need for better therapeutic targets. Cancer cells have increased demand for sugars, amino acids, and lipids and therefore up-regulate various nutrient transporters to meet this demand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6167ea5b61895d5cd0586ac06f9f23c7
https://doi.org/10.1042/bcj20210855
https://doi.org/10.1042/bcj20210855
Autor:
Ksenija Korac, Bradley Schniers, Vadivel Ganapathy, Tyler Sniegowski, Devaraja Rajasekaran, Yangzom D. Bhutia
Publikováno v:
Biochemical Journal
PEPT1 is a proton-coupled peptide transporter that is up-regulated in PDAC cell lines and PDXs, with little expression in the normal pancreas. However, the relevance of this up-regulation to cancer progression and the mechanism of up-regulation have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9d8839e66cf966fa6f7589c93dc593
https://doi.org/10.1042/bcj20210377
https://doi.org/10.1042/bcj20210377
Autor:
Ksenija Korac, Devaraja Rajasekaran, Tyler Sniegowski, Bradley K. Schniers, Andrew F. Ibrahim, Yangzom D. Bhutia
Publikováno v:
The Biochemical journal. 479(17)
IDO1 is an immunomodulatory enzyme responsible for tryptophan catabolism. Its expression in immune cells, especially the DCs, has attracted attention because it leads to tryptophan depletion at the immunological synapse, thereby causing T-cell anergy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911fb9ac295687d9dc89bf6a24f3bce4
https://pubmed.ncbi.nlm.nih.gov/35997090
https://pubmed.ncbi.nlm.nih.gov/35997090
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 14, Iss 216, p 216 (2021)
Pharmaceuticals, Vol 14, Iss 216, p 216 (2021)
The glutaminolysis and serine–glycine–one-carbon pathways represent metabolic reactions that are reprogramed and upregulated in cancer; these pathways are involved in supporting the growth and proliferation of cancer cells. Glutaminolysis partici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21099be54dd4299e99035d0b9d0298b7
http://europepmc.org/articles/PMC8000594
http://europepmc.org/articles/PMC8000594
Autor:
Larry M Mallis, David Revelli, Steven A. Belinsky, Carmen S. Tellez, David T. Vodak, Thomas H. March, Michael Burke, Aaron M. Badenoch, Marcie J. Grimes, Philip J. Kuehl, Maria A. Picchi, Wendy W Dye, Devon B Dubose, Tyler Sniegowski, Mathewos Tessema
Publikováno v:
British Journal of Cancer
Background Epigenetic therapy through demethylation of 5-methylcytosine has been largely ineffective in treating lung cancer, most likely due to poor tissue distribution with oral or subcutaneous delivery of drugs such as 5-azacytidine (5AZA). An inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9766125b78ed3fd6298e0ead96ff763c
https://pubmed.ncbi.nlm.nih.gov/32103148
https://pubmed.ncbi.nlm.nih.gov/32103148