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of 7
pro vyhledávání: '"Tyler S. Klann"'
Autor:
Joshua B. Black, Sean R. McCutcheon, Shataakshi Dube, Alejandro Barrera, Tyler S. Klann, Grayson A. Rice, Shaunak S. Adkar, Scott H. Soderling, Timothy E. Reddy, Charles A. Gersbach
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108460- (2020)
Summary: Technologies to reprogram cell-type specification have revolutionized the fields of regenerative medicine and disease modeling. Currently, the selection of fate-determining factors for cell reprogramming applications is typically a laborious
Externí odkaz:
https://doaj.org/article/e5a854fcace44b25a18afb8d37a05c63
Autor:
Madeleine J. Sitton, Charles A. Gersbach, Luke C. Bartelt, Chase L. Beisel, Mae M. Lewis, Kylie A. Gilcrest, Tyler S. Klann, Adrian Pickar-Oliver, Rodolphe Barrangou, Joshua B. Black, Christopher E. Nelson, Alejandro Barrera, Kevin J. Mutchnick, Timothy E. Reddy
Publikováno v:
Nature biotechnology
Class 2 CRISPR-Cas systems, such as Cas9 and Cas12, have been widely used to target DNA sequences in eukaryotic genomes. However, class 1 CRISPR-Cas systems, which represent about 90% of all CRISPR systems in nature, remain largely unexplored for gen
Autor:
Charles A. Gersbach, So Young Kim, Jianguo Huang, Lixia Luo, Tyler S. Klann, Yan Ma, Wesley Huang, Mark Chen, Eric S. Xu, Warren Floyd, David G. Kirsch, Diana M. Cardona
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Cooperating gene mutations are typically required to transform normal cells enabling growth in soft agar or in immunodeficient mice. For example, mutations in Kras and transformation-related protein 53 (Trp53) are known to transform a variety of mese
Autor:
Timothy E. Reddy, Joshua B. Black, Alexias Safi, Lingyun Song, Isaac B. Hilton, Malathi Chellappan, Gregory E. Crawford, Tyler S. Klann, Charles A. Gersbach
Publikováno v:
Nature biotechnology
Large genome-mapping consortia and thousands of genome-wide association studies have identified non-protein-coding elements in the genome as having a central role in various biological processes. However, decoding the functions of the millions of put
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1767
Genomic regulatory elements that control gene expression play an important role in many traits and diseases. Identifying the regulatory elements associated with each gene or phenotype and understanding the function of that element remain a significan
Developments in CRISPR/Cas9-based technologies provide a new paradigm in functional screening of the genome. Conventional screening methods have focused on high-throughput perturbations of the protein-coding genome with technologies such as RNAi. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4cdfdb1579dc112e26e78eeff0cb879
https://europepmc.org/articles/PMC6082715/
https://europepmc.org/articles/PMC6082715/
Autor:
Tyler S. Klann, Ami M. Kabadi, Malathi Chellappan, Charles A. Gersbach, Timothy E. Reddy, Jennifer B. Kwon
Publikováno v:
Molecular Therapy. 24:S210
The advent of cellular reprogramming has introduced new possibilities for regenerative medicine, drug discovery, and controlling cellular behavior. Recent studies have identified many natural transcription factors that are capable of directing lineag