Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tyler S. Halpin-Healy"'
Autor:
George D. Lampe, Rebeca T. King, Tyler S. Halpin-Healy, Sanne E. Klompe, Marcus I. Hogan, Phuc Leo H. Vo, Stephen Tang, Alejandro Chavez, Samuel H. Sternberg
Publikováno v:
Nature Biotechnology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23f5be4d30797441e7f22401a637dca6
https://doi.org/10.1038/s41587-023-01748-1
https://doi.org/10.1038/s41587-023-01748-1
Autor:
George D. Lampe, Rebeca T. King, Tyler S. Halpin-Healy, Sanne E. Klompe, Marcus I. Hogan, Phuc Leo H. Vo, Stephen Tang, Alejandro Chavez, Samuel H. Sternberg
Publikováno v:
bioRxiv
Traditional genome-editing reagents such as CRISPR-Cas9 achieve targeted DNA modification by introducing double-strand breaks (DSBs), thereby stimulating localized DNA repair by endogenous cellular repair factors. While highly effective at generating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedf336c5dfa340acb16ed7115aea378
https://europepmc.org/articles/PMC10055298/
https://europepmc.org/articles/PMC10055298/
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Bacteria use adaptive immune systems encoded by CRISPR and Cas genes to maintain genomic integrity when challenged by pathogens and mobile genetic elements1,2,3. Type I CRISPR–Cas systems typically target foreign DNA for degradation via joint actio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6535059ddab9916692f380959b18f350
https://doi.org/10.1038/s41586-019-1849-0
https://doi.org/10.1038/s41586-019-1849-0
Publikováno v:
Nature. 571:219-225
Conventional CRISPR-Cas systems maintain genomic integrity by leveraging guide RNAs for the nuclease-dependent degradation of mobile genetic elements, including plasmids and viruses. Here we describe a notable inversion of this paradigm, in which bac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c579a9cc035727c290c08e3fdcee601
https://doi.org/10.1038/s41586-019-1323-z
https://doi.org/10.1038/s41586-019-1323-z
Publikováno v:
Nature. 585(7825)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b955a5d7bdedbf840e265a4d02fe3f
https://pubmed.ncbi.nlm.nih.gov/31853065
https://pubmed.ncbi.nlm.nih.gov/31853065
Publikováno v:
Nature. 577(7789)
Bacteria use adaptive immune systems encoded by CRISPR and Cas genes to maintain genomic integrity when challenged by pathogens and mobile genetic elements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a53bcb8a7953e8473acab25b5ec8e0f
https://pubmed.ncbi.nlm.nih.gov/32843756
https://pubmed.ncbi.nlm.nih.gov/32843756
Publikováno v:
Nature. 571(7764)
Conventional CRISPR-Cas systems maintain genomic integrity by leveraging guide RNAs for the nuclease-dependent degradation of mobile genetic elements, including plasmids and viruses. Here we describe a notable inversion of this paradigm, in which bac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c4d9b51a291a18ff750324bcf2adeaf
https://pubmed.ncbi.nlm.nih.gov/31550477
https://pubmed.ncbi.nlm.nih.gov/31550477