Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tyler S Browne"'
Autor:
Dalton T. Ham, Tyler S. Browne, Pooja N. Banglorewala, Tyler L. Wilson, Richard K. Michael, Gregory B. Gloor, David R. Edgell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The CRISPR/Cas9 nuclease from Streptococcus pyogenes (SpCas9) can be used with single guide RNAs (sgRNAs) as a sequence-specific antimicrobial agent and as a genome-engineering tool. However, current bacterial sgRNA activity models struggle
Externí odkaz:
https://doaj.org/article/e91f69064291470d9447cda6db83c808
Autor:
Samuel S. Slattery, Daniel J. Giguere, Emily E. Stuckless, Arina Shrestha, Lee-Ann K. Briere, Alexa Galbraith, Stephen Reaume, Xenia Boyko, Henry H. Say, Tyler S. Browne, Mallory I. Frederick, Jeremy T. Lant, Ilka U. Heinemann, Patrick O’Donoghue, Liann Dsouza, Steven Martin, Peter Howard, Christopher Jedeszko, Kinza Ali, Garth Styba, Martin Flatley, Bogumil J. Karas, Gregory B. Gloor, David R. Edgell
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The worldwide COVID-19 pandemic caused by the SARS-CoV-2 betacoronavirus has highlighted the need for a synthetic biology approach to create reliable and scalable sources of viral antigen for uses in diagnostics, therapeutics and basic biome
Externí odkaz:
https://doaj.org/article/addb994c28b44678acdeb227ced926e1
Autor:
Daniel J. Giguere, Alexander T. Bahcheli, Samuel S. Slattery, Rushali R. Patel, Tyler S. Browne, Martin Flatley, Bogumil J. Karas, David R. Edgell, Gregory B. Gloor
Publikováno v:
PeerJ, Vol 10, p e13607 (2022)
Phaeodactylum tricornutum is a marine diatom with a growing genetic toolbox available and is being used in many synthetic biology applications. While most of the genome has been assembled, the currently available genome assembly is not a completed te
Externí odkaz:
https://doaj.org/article/f232fb4cb60c41b98323c22c74f590df
Autor:
Gregory M Pellegrino, Tyler S Browne, Keerthana Sharath, Khaleda A Bari, Sarah J Vancuren, Emma Allen-Vercoe, Gregory B Gloor, David R Edgell
Publikováno v:
Nucleic Acids Research. 51:982-996
The ability to restrict gene expression to a relevant bacterial species in a complex microbiome is an unsolved problem. In the context of the human microbiome, one desirable target metabolic activity are glucuronide-utilization enzymes (GUS) that are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c7977f27ee4f6fd767730d91b9020e4
https://doi.org/10.1093/nar/gkac1248
https://doi.org/10.1093/nar/gkac1248
Autor:
Thomas A. Hamilton, Benjamin R. Joris, Arina Shrestha, Tyler S. Browne, Sébastien Rodrigue, Bogumil J. Karas, Gregory B. Gloor, David R. Edgell
Metagenomic sequence represents an untapped source of genetic novelty, particularly for conjugative systems that could be used for plasmid-based delivery of Cas9-derived antimicrobial agents. However, unlocking the functional potential of conjugative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac3c11cfa6e6c2f74c66f0a7e4e0f3ea
https://doi.org/10.1101/2023.05.10.540216
https://doi.org/10.1101/2023.05.10.540216
Identification of type IV conjugative systems that are systematically excluded from metagenomic bins
BackgroundConjugation enables the exchange of genetic elements throughout environments, including the human gut microbiome. Conjugative elements can carry and transfer clinically relevant metabolic pathways which makes precise identification of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::965710dcbd9d67461aba82249cb14953
https://doi.org/10.21203/rs.3.rs-1428512/v1
https://doi.org/10.21203/rs.3.rs-1428512/v1
Autor:
Samuel S. Slattery, Daniel J. Giguere, Emily E. Stuckless, Arina Shrestha, Lee-Ann K. Briere, Alexa Galbraith, Stephen Reaume, Xenia Boyko, Henry H. Say, Tyler S. Browne, Mallory I. Frederick, Jeremy T. Lant, Ilka U. Heinemann, Patrick O’Donoghue, Liann Dsouza, Steven Martin, Peter Howard, Christopher Jedeszko, Kinza Ali, Garth Styba, Martin Flatley, Bogumil J. Karas, Gregory B. Gloor, David R. Edgell
Publikováno v:
Scientific reports. 12(1)
The worldwide COVID-19 pandemic caused by the SARS-CoV-2 betacoronavirus has highlighted the need for a synthetic biology approach to create reliable and scalable sources of viral antigen for uses in diagnostics, therapeutics and basic biomedical res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d174156761934a5ded90634e359680ab
https://pubmed.ncbi.nlm.nih.gov/35487958
https://pubmed.ncbi.nlm.nih.gov/35487958
Conjugation enables the exchange of genetic elements throughout environments, including the human gut microbiome. Conjugative elements can carry and transfer clinically relevant metabolic pathways which makes precise identification of these systems i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de652e66fe1522ff90b6c3718b04286
https://doi.org/10.21203/rs.3.rs-660934/v1
https://doi.org/10.21203/rs.3.rs-660934/v1
Autor:
Daniel J, Giguere, Alexander T, Bahcheli, Samuel S, Slattery, Rushali R, Patel, Tyler S, Browne, Martin, Flatley, Bogumil J, Karas, David R, Edgell, Gregory B, Gloor
Publikováno v:
PeerJ. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6931476155b1551c4f4d4c574dc23f9b
https://pubmed.ncbi.nlm.nih.gov/35811822
https://pubmed.ncbi.nlm.nih.gov/35811822