Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Tyler Risom"'
Autor:
Aalok Patwa, Rikiya Yamashita, Jin Long, Tyler Risom, Michael Angelo, Leeat Keren, Daniel L. Rubin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Patwa, Yamashita et al. utilize multiplexed imaging to demonstrate that profiling cell-to-cell interactions in the microenvironment can reveal predictors of recurrence and overall survival in triple-negative breast cancer, especially highlighting the
Externí odkaz:
https://doaj.org/article/accef0e4e5044d8990a14811008e28a2
Autor:
Tyler Risom, Ellen M. Langer, Margaret P. Chapman, Juha Rantala, Andrew J. Fields, Christopher Boniface, Mariano J. Alvarez, Nicholas D. Kendsersky, Carl R. Pelz, Katherine Johnson-Camacho, Lacey E. Dobrolecki, Koei Chin, Anil J. Aswani, Nicholas J. Wang, Andrea Califano, Michael T. Lewis, Claire J. Tomlin, Paul T. Spellman, Andrew Adey, Joe W. Gray, Rosalie C. Sears
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Resistance to therapy can be driven by intratumoral heterogeneity. Here, the authors show that drug tolerant persistent cell populations emerge during treatment, and these emergent populations arise through epigenetically mediated cell state transiti
Externí odkaz:
https://doaj.org/article/b334216fc1b74e778b875f012ede0e20
Autor:
Margaret P Chapman, Tyler Risom, Anil J Aswani, Ellen M Langer, Rosalie C Sears, Claire J Tomlin
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 10, p e1007441 (2019)
[This corrects the article DOI: 10.1371/journal.pcbi.1006840.].
Externí odkaz:
https://doaj.org/article/064b9d00d7d045b08673f0d3fc579413
Autor:
Margaret P Chapman, Tyler Risom, Anil J Aswani, Ellen M Langer, Rosalie C Sears, Claire J Tomlin
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 3, p e1006840 (2019)
Drug resistance in breast cancer cell populations has been shown to arise through phenotypic transition of cancer cells to a drug-tolerant state, for example through epithelial-to-mesenchymal transition or transition to a cancer stem cell state. Howe
Externí odkaz:
https://doaj.org/article/188d5af0f28e4f20934e8697bde2afa1
Autor:
Rosalie C. Sears, Goutham Narla, Michael Ohlmeyer, Dale J. Christensen, Brett Sheppard, Charles D. Lopez, Owen J. Sansom, Jennifer P. Morton, Katherine R. Pelz, Mary C. Thoma, Zina P. Jenny, Zhiping Wang, Zipei Feng, Tyler Risom, Brittany L. Allen-Petersen
Results of Kinase Inhibitor Screen including compound names, IC50s, and fold change compared to vehicle.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298272d763f56207a4f8b0acbfb53814
https://doi.org/10.1158/0008-5472.22421378.v1
https://doi.org/10.1158/0008-5472.22421378.v1
Autor:
Kui Lin, Lori S. Friedman, Elizabeth Punnoose, Marcia Belvin, Jeffrey J. Wallin, Nicholas J. Skelton, Hartmut Koeppen, Bianca M. Liederer, Stefan Gross, Tyler Risom, Leslie B. Lee, Robert Kassees, Rebecca Hong, Zhengyu Guan, Heidi Savage, Jason Oeh, Michael Degtyarev, Brian B. Lee, Michelle A. Nannini, Deepak Sampath, Jie Lin
PDF file - 94K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e28628965bd5c2946f0b8f30a83eb4
https://doi.org/10.1158/1078-0432.22455131.v1
https://doi.org/10.1158/1078-0432.22455131.v1
Autor:
Kui Lin, Lori S. Friedman, Elizabeth Punnoose, Marcia Belvin, Jeffrey J. Wallin, Nicholas J. Skelton, Hartmut Koeppen, Bianca M. Liederer, Stefan Gross, Tyler Risom, Leslie B. Lee, Robert Kassees, Rebecca Hong, Zhengyu Guan, Heidi Savage, Jason Oeh, Michael Degtyarev, Brian B. Lee, Michelle A. Nannini, Deepak Sampath, Jie Lin
Purpose: We describe the preclinical pharmacology and antitumor activity of GDC-0068, a novel highly selective ATP-competitive pan-Akt inhibitor currently in clinical trials for the treatment of human cancers.Experimental Design: The effect of GDC-00
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83abf89be72a90f834045029a21f1a26
https://doi.org/10.1158/1078-0432.c.6522932.v1
https://doi.org/10.1158/1078-0432.c.6522932.v1
Autor:
Kui Lin, Lori S. Friedman, Elizabeth Punnoose, Marcia Belvin, Jeffrey J. Wallin, Nicholas J. Skelton, Hartmut Koeppen, Bianca M. Liederer, Stefan Gross, Tyler Risom, Leslie B. Lee, Robert Kassees, Rebecca Hong, Zhengyu Guan, Heidi Savage, Jason Oeh, Michael Degtyarev, Brian B. Lee, Michelle A. Nannini, Deepak Sampath, Jie Lin
PDF file - 954K, Supplemental Figures: Figure S1. Chemical structure of the Akt inhibitor GDC-0068. Figure S2. Effect of GDC-0068 on cell cycle and apoptotic response on PC-3 and MCF7-neo/HER2 cell lines. Figure S3. Western blot analysis of indicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091abdb4dab0760c8b3bb36517167f0f
https://doi.org/10.1158/1078-0432.22455134.v1
https://doi.org/10.1158/1078-0432.22455134.v1
Autor:
Rosalie C. Sears, Goutham Narla, Michael Ohlmeyer, Dale J. Christensen, Brett Sheppard, Charles D. Lopez, Owen J. Sansom, Jennifer P. Morton, Katherine R. Pelz, Mary C. Thoma, Zina P. Jenny, Zhiping Wang, Zipei Feng, Tyler Risom, Brittany L. Allen-Petersen
Viability assays, Soft agar, Immunoprecipitation, Kinase inhibitor screen, and Patient outcome data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446537c73f9efea03dca3e1abae52f85
https://doi.org/10.1158/0008-5472.22421369.v1
https://doi.org/10.1158/0008-5472.22421369.v1
Autor:
Rosalie C. Sears, Goutham Narla, Michael Ohlmeyer, Dale J. Christensen, Brett Sheppard, Charles D. Lopez, Owen J. Sansom, Jennifer P. Morton, Katherine R. Pelz, Mary C. Thoma, Zina P. Jenny, Zhiping Wang, Zipei Feng, Tyler Risom, Brittany L. Allen-Petersen
Results of the Phosphokinase Array with phosphorylation sites, fold change relative to vehicle, and Kmeans clustering.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0088b85088bf7a980881e3de059f98
https://doi.org/10.1158/0008-5472.22421375.v1
https://doi.org/10.1158/0008-5472.22421375.v1