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Increased cell-free mitochondrial DNA is a marker of ongoing inflammation and better neurocognitive function in virologically suppressed HIV-infected individuals

Autor: Perez-Santiago, Josue, De Oliveira, Michelli F, Var, Susanna R, Day, Tyler RC, Woods, Steven P, Gianella, Sara, Mehta, Sanjay R

Publikováno v: Journal of neurovirology, vol 23, iss 2
Perez-Santiago, Josue; De Oliveira, Michelli F; Var, Susanna R; Day, Tyler RC; Woods, Steven P; Gianella, Sara; et al.(2017). Increased cell-free mitochondrial DNA is a marker of ongoing inflammation and better neurocognitive function in virologically suppressed HIV-infected individuals. JOURNAL OF NEUROVIROLOGY, 23(2), 283-289. doi: 10.1007/s13365-016-0497-5. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/98c6k4hz

Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::11b84aabfa343f47b0bccd3c961dd08a
https://escholarship.org/uc/item/98c6k4hz

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Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment

Publikováno v: Mehta, Sanjay R; Perez-Santiago, Josue; Hulgan, Todd; Day, Tyler RC; Barnholtz-Sloan, Jill; Gittleman, Haley; et al.(2017). Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment. JOURNAL OF NEUROINFLAMMATION, 14(1), 72. doi: 10.1186/s12974-017-0848-z. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0x24019k

Mitochondria are abundant organelles critical for energy metabolism and brain function. Mitochondrial DNA (mtDNA), released during cellular injury and as part of the innate immune response to viral pathogens, contains CpG motifs that act as TLR-9 lig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::b4e9cdd8bf129fd310c6216ab1846e0d
http://www.escholarship.org/uc/item/0x24019k

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HIV viral kinetics and T cell dynamics in antiretroviral naïve persons starting an integrase strand transfer inhibitor and protease inhibitor regimen

Autor: Karris, Maile Y, Jain, Sonia, Day, Tyler RC, Pérez-Santiago, Josué, Goicoechea, Miguel, Dubé, Michael P, Sun, Xiaoying, Spina, Celsa, Daar, Eric S, Haubrich, Richard H, Morris, Sheldon, California Collaborative Treatment Group (CCTG) 589 Study Team

Publikováno v: HIV clinical trials, vol 18, iss 2

BackgroundNucleos(t)ide reverse transcriptase inhibitor (NRTI)-sparing regimens may potentially minimize antiretroviral (ART) toxicities, but demonstrate mixed efficacy and toxicity results. The impact of an integrase strand transfer inhibitor (INSTI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::22f98b84001dadace26d2565ecc9e1dc
https://escholarship.org/uc/item/3ms9z2jt

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Subtype associations with HIV-associated neurocognitive disorder in China

Autor: Day, Tyler RC, Smith, Davey M, Heaton, Robert K, Franklin, Donald, Tilghman, Myers W, Letendre, Scott, Jin, Hua, Wu, Zunyou, Shi, Chuan, Yu, Xin, Pérez-Santiago, Josué

Publikováno v: Day, Tyler RC; Smith, Davey M; Heaton, Robert K; Franklin, Donald; Tilghman, Myers W; Letendre, Scott; et al.(2016). Subtype associations with HIV-associated neurocognitive disorder in China.. Journal of neurovirology, 22(2), 246-250. doi: 10.1007/s13365-015-0377-4. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/8c48s818

Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::8ee7aa474aa17e51fad40fbb0ff330d7
http://www.escholarship.org/uc/item/8c48s818

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