Výsledky vyhledávání - "Tyler R, Lambeth"

Proteolysis of Amyloid β by Lysosomal Enzymes as a Function of Fibril Morphology

Publikováno v: ACS Omega
ACS Omega, Vol 6, Iss 47, Pp 31520-31527 (2021)

Aggregation of amyloid-β (Aβ) into extracellular plaques is a well-known hallmark of Alzheimer’s disease (AD). Similarly, autophagic vacuoles, autophagosomes, and other residual bodies within dystrophic neurites, though more difficult to detect,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74cf503ce974f58e195dea825258d41
https://doi.org/10.1021/acsomega.1c03915

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First in Human Evaluation and Dosimetry Calculations for Peptide 124I-p5+14—a Novel Radiotracer for the Detection of Systemic Amyloidosis Using PET/CT Imaging

Autor: Ronald H. Lands, Michael G. Stabin, Dustin Powell, Bryan Whittle, Aaron Endsley, Alan Stuckey, Ryan R. Julian, Tyler R. Lambeth, Emily B. Martin, Stephen J. Kennel, Angela Williams, Jonathan S. Wall, Sarah Hall

Publikováno v: Molecular Imaging and Biology. 24:479-488

Purpose Accurate diagnosis of amyloidosis remains a significant clinical challenge and unmet need for patients. The amyloid-reactive peptide p5+14 radiolabeled with iodine-124 has been developed for the detection of amyloid by PET/CT imaging. In a fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36afe720dfd02194efcd85765f374692
https://doi.org/10.1007/s11307-021-01681-2

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Efficient Isothiocyanate Modification of Peptides Facilitates Structural Analysis by Radical-Directed Dissociation

Autor: Tyler R. Lambeth, Ryan R. Julian

Publikováno v: Journal of the American Society for Mass Spectrometry. 33:1338-1345

Radical-directed dissociation (RDD) is a powerful technique for structural characterization of peptides in mass spectrometry experiments. Prior to analysis, a radical precursor must typically be appended to facilitate generation of a free radical. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8120f8900d439d4cccd8897d0111ea98
https://doi.org/10.1021/jasms.1c00237

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PIMT-Mediated Labeling of L-isoAspartic Acid with Tris Facilitates Identification of Isomerization Sites in Long-Lived Proteins

Autor: Jacob W. Silzel, Tyler R. Lambeth, Ryan R. Julian

Publikováno v: J Am Soc Mass Spectrom
Journal of the American Society for Mass Spectrometry, vol 33, iss 3

Isomerization of individual residues in long-lived proteins (LLPs) is a subject of growing interest in connection with many age-related human diseases. When isomerization occurs in LLPs, it can lead to deleterious changes in protein structure, functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4104caa3eadca7c4557fee6c337d4dab
https://europepmc.org/articles/PMC9930442/

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First in Human Evaluation and Dosimetry Calculations for Peptide

Autor: Jonathan S, Wall, Emily B, Martin, Aaron, Endsley, Alan C, Stuckey, Angela D, Williams, Dustin, Powell, Bryan, Whittle, Sarah, Hall, Tyler R, Lambeth, Ryan R, Julian, Michael, Stabin, Ronald H, Lands, Stephen J, Kennel

Publikováno v: Molecular imaging and biology. 24(3)

Accurate diagnosis of amyloidosis remains a significant clinical challenge and unmet need for patients. The amyloid-reactive peptide p5+14 radiolabeled with iodine-124 has been developed for the detection of amyloid by PET/CT imaging. In a first-in-h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a081654bcfb59baca79913553c509b5
https://pubmed.ncbi.nlm.nih.gov/34786667

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Internal Fragments Generated from Different Top-Down Mass Spectrometry Fragmentation Methods Extend Protein Sequence Coverage

Autor: Ryan R. Julian, Carter Lantz, Tyler R. Lambeth, Benqian Wei, Hoi Ting Wu, Rachel R. Ogorzalek Loo, Joseph A. Loo, Jolene K. Diedrich, Muhammad A. Zenaidee

Publikováno v: Journal of the American Society for Mass Spectrometry, vol 32, iss 7
J Am Soc Mass Spectrom

Top-down mass spectrometry (TD-MS) of intact proteins results in fragment ions that can be correlated to the protein primary sequence. Fragments generated can either be terminal fragments that contain the N- or C- terminus, or internal fragments that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3986eb5e996c8dae3b408a5c91a7430b
https://escholarship.org/uc/item/2744849d

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