Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tyler Picariello"'
Autor:
Tyler Picariello, Yuqing Hou, Tomohiro Kubo, Nathan A McNeill, Haru-Aki Yanagisawa, Toshiyuki Oda, George B Witman
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232594 (2020)
Generation and subsequent analysis of mutants is critical to understanding the functions of genes and proteins. Here we describe TIM, an efficient, cost-effective, CRISPR-based targeted insertional mutagenesis method for the model organism Chlamydomo
Externí odkaz:
https://doaj.org/article/96a3b69401304c08a21069307eb34f8a
Autor:
Jenna L Wingfield, Ilaria Mengoni, Heather Bomberger, Yu-Yang Jiang, Jonathon D Walsh, Jason M Brown, Tyler Picariello, Deborah A Cochran, Bing Zhu, Junmin Pan, Jonathan Eggenschwiler, Jacek Gaertig, George B Witman, Peter Kner, Karl Lechtreck
Publikováno v:
eLife, Vol 6 (2017)
Intraflagellar transport (IFT) trains, multimegadalton assemblies of IFT proteins and motors, traffic proteins in cilia. To study how trains assemble, we employed fluorescence protein-tagged IFT proteins in Chlamydomonas reinhardtii. IFT-A and motor
Externí odkaz:
https://doaj.org/article/d5e81191a8b840c585d4a90e0e20d613
Autor:
Bing Wang, Mandy M. Smith, Stefano Zanotti, Stephen L. Madden, Hervé Husson, Vijay Modur, Laurie A. Smith, Nikolay O. Bukanov, Thomas A. Natoli, Sarah Moreno, Tyler Picariello, Katherine W. Klinger, Brenda Richards, Hyejung Park, Cheng Zhu, Oxana Ibraghimov-Beskrovnaya, Ryan J. Russo
Publikováno v:
Human Molecular Genetics
Bardet–Biedl syndrome (BBS) is a pleiotropic autosomal recessive ciliopathy affecting multiple organs. The development of potential disease-modifying therapy for BBS will require concurrent targeting of multi-systemic manifestations. Here, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7481d69b1504e2abb5077cf41fe841
https://doi.org/10.1093/hmg/ddaa138
https://doi.org/10.1093/hmg/ddaa138
Publikováno v:
The Journal of Cell Biology
The central apparatus is an essential component of “9+2” cilia. Zhao et al. identify more than 40 new potential components of the central apparatus of Chlamydomonas. Many are conserved and will facilitate genetic screening of patients with a form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1454db262a1c1df9fdf5d6f65b4f13
https://doi.org/10.1083/jcb.201902017
https://doi.org/10.1083/jcb.201902017
Autor:
Thomas A. Natoli, Kelly A. Rogers, Nickolay Bukanov, Tyler Picariello, Christina Bracken, Oxana Ibraghimov-Beskrovnaya, Laurie A. Smith
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Polycystic kidney disease (PKD) is characterized by the formation and progressive growth of renal cysts ultimately leading to end-stage renal disease (ESRD). Previous work has shown that treatment of PKD mouse models with a glucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9394fd189c69da309fd219e82e2a89fd
https://doi.org/10.1093/ndt/gfaa143.p0029
https://doi.org/10.1093/ndt/gfaa143.p0029
Publikováno v:
Cilia
Cilia, Vol 8, Iss 1, Pp 1-21 (2019)
Cilia, Vol 8, Iss 1, Pp 1-21 (2019)
BackgroundCilia emanate from basal bodies just underneath the cell membrane. Basal bodies must withstand torque from the ciliary beat and be appropriately spaced for cilia to beat in metachronal waves. Basal body rootlets provide stability for motile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb500eccf58abb53d8773bb165ae0da
http://europepmc.org/articles/PMC6819543
http://europepmc.org/articles/PMC6819543
Autor:
George B. Witman, Jason M. Brown, Oliver D. King, Gregory J. Pazour, Tyler Picariello, Yuqing Hou, Gregory Swank, Deborah A. Cochran, Karl F. Lechtreck
Publikováno v:
Journal of Cell Science.
Intraflagellar transport (IFT), which is essential for the formation and function of cilia in most organisms, is the trafficking of IFT trains (i.e. assemblies of IFT particles) that carry cargo within the cilium. Defects in IFT cause several human d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c423205fc687aaa26d15cd235dedd6
https://doi.org/10.1242/jcs.220749
https://doi.org/10.1242/jcs.220749
Autor:
Yu-Yang Jiang, Jenna L Wingfield, Jason M. Brown, Tyler Picariello, Heather Bomberger, George B. Witman, Ilaria Mengoni, Deborah A. Cochran, Peter Kner, Jacek Gaertig, Junmin Pan, Karl F. Lechtreck, Bing Zhu, Jonathan T. Eggenschwiler, Jonathon D. Walsh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18741ba6517ed1b03323047e484e03f8
https://doi.org/10.7554/elife.26609.024
https://doi.org/10.7554/elife.26609.024
Autor:
Bing Zhu, George B. Witman, Peter Kner, Tyler Picariello, Heather Bomberger, Karl F. Lechtreck, Jonathan T. Eggenschwiler, Jonathon D. Walsh, Jason M. Brown, Ilaria Mengoni, Jenna L Wingfield, Junmin Pan, Deborah A. Cochran, Jacek Gaertig, Yu-Yang Jiang
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Intraflagellar transport (IFT) trains, multimegadalton assemblies of IFT proteins and motors, traffic proteins in cilia. To study how trains assemble, we employed fluorescence protein-tagged IFT proteins in Chlamydomonas reinhardtii. IFT-A and motor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd4ca80655e6e94668f2ecf28187fe9
http://europepmc.org/articles/PMC5451262
http://europepmc.org/articles/PMC5451262
Publikováno v:
Cilia
Background Meckelin (MKS3), a conserved protein linked to Meckel Syndrome, assists in themigration of centrioles to the cell surface for ciliogenesis. We explored foradditional functions of MKS3p using RNA interference (RNAi) and expression of FLAGep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2096c09412e3daf7b9eac839461ceaf