Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tyler P. Korman"'
Autor:
Saken Sherkhanov, Tyler P. Korman, Sum Chan, Salem Faham, Hongjiang Liu, Michael R. Sawaya, Wan-Ting Hsu, Ellee Vikram, Tiffany Cheng, James U. Bowie
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
A cell free or synthetic biochemistry approach offers a way to circumvent the many constraints of living cells. Here, the authors demonstrate, via enzyme and process enhancements, the production of isobutanol with the metrics exceeding highly develop
Externí odkaz:
https://doaj.org/article/6d928504ca27437ea5b6a0df6826c323
Autor:
Meaghan A. Valliere, Tyler P. Korman, Nicholas B. Woodall, Gregory A. Khitrov, Robert E. Taylor, David Baker, James U. Bowie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Producing individual cannabinoids by metabolically engineered microbes has proven challenging. Here, the authors develop a cell-free enzymatic prenylating system to generate isoprenyl pyrophosphate substrates directly from glucose and produce both co
Externí odkaz:
https://doaj.org/article/91846144fed24fbd93ae5a96ab7c927a
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Terpenes are bioactive natural products derived from plants with several commercial applications. Here, the authors engineer a cell-free system composed of 27 enzymes that convert glucose into terpenes, highlighting the potential of synthetic biochem
Externí odkaz:
https://doaj.org/article/bb8ace10bdcb41a5a7a1b989f4dffc78
Autor:
Meaghan A. Valliere, Tyler P. Korman, Nicholas B. Woodall, Gregory A. Khitrov, Robert E. Taylor, David Baker, James U. Bowie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
In the original version of this Article, the genotype of the M30 mutant presented in Fig. 3b was given incorrectly as Y288V/A232S, and the M31 mutant was given incorrectly as M1/A232S. The correct genotype of the M30 mutant is Y288A/A232S and for M31
Externí odkaz:
https://doaj.org/article/6f029ec8655a4654b94ece5ae0d798c1
Publikováno v:
Nature Chemical Biology. 16:1427-1433
Moving cannabinoid production away from the vagaries of plant extraction and into engineered microbes could provide a consistent, purer, cheaper and environmentally benign source of these important therapeutic molecules, but microbial production face
Autor:
Tiffany Yi-Mei Cheng, Saken Sherkhanov, Wan-Ting Hsu, Hongjiang Liu, James U. Bowie, Ellee Vikram, Salem Faham, Sum Chan, Tyler P. Korman, Michael R. Sawaya
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Cost competitive conversion of biomass-derived sugars into biofuel will require high yields, high volumetric productivities and high titers. Suitable production parameters are hard to achieve in cell-based systems because of the need to maintain life
Autor:
Hongjiang Liu, Meaghan Valliere, James U. Bowie, Paul H. Opgenorth, Saken Sherkhanov, Tyler P. Korman
Publikováno v:
Trends in Biotechnology. 38:766-778
Metabolic engineering efforts that harness living organisms to produce natural products and other useful chemicals face inherent difficulties because the maintenance of life processes often runs counter to our desire to maximize important production
Autor:
David Baker, Robert E. Taylor, Tyler P. Korman, Meaghan Valliere, James U. Bowie, Gregory A. Khitrov, Nicholas B. Woodall
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Prenylation of natural compounds adds structural diversity, alters biological activity, and enhances therapeutic potential. Because prenylated compounds often have a low natural abundance, alternative production methods are needed. Metabolic engineer
Publikováno v:
Nature chemical biology. 16(12)
Moving cannabinoid production away from the vagaries of plant extraction and into engineered microbes could provide a consistent, purer, cheaper and environmentally benign source of these important therapeutic molecules, but microbial production face
Publikováno v:
Nature communications, vol 8, iss 1
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Nature Communications
Cell-free systems designed to perform complex chemical conversions of biomass to biofuels or commodity chemicals are emerging as promising alternatives to the metabolic engineering of living cells. Here we design a system comprises 27 enzymes for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff168e57fecf3e7d00787e26b9128825
https://escholarship.org/uc/item/628968p4
https://escholarship.org/uc/item/628968p4