Hippocampal subfield imaging and fractional anisotropy show parallel changes in Alzheimer's disease tau progression using simultaneous tau‐PET/MRI at 3T

Autor: Mackenzie L. Carlson, Tyler N. Toueg, M. Mehdi Khalighi, Jessa Castillo, Bin Shen, Emily C. Azevedo, Phillip DiGiacomo, Nicole Mouchawar, Gustavo Chau, Greg Zaharchuk, Michelle L. James, Elizabeth C. Mormino, Michael M. Zeineh

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)

Abstract Introduction Alzheimer's disease (AD) is the most common form of dementia, characterized primarily by abnormal aggregation of two proteins, tau and amyloid beta. We assessed tau pathology and white matter connectivity changes in subfields of

Externí odkaz: https://doaj.org/article/d1ec6ce14dac4ea6bd9b4cdc12a28ec8

True ultra-low-dose amyloid PET/MRI enhanced with deep learning for clinical interpretation

Autor: Kim Halbert, Athanasia Boumis, Harsh Gandhi, Dawn Holley, Kevin Chen, Tyler N. Toueg, Mehdi Khalighi, Greg Zaharchuk, Michael Zeineh, Mary Ellen I. Koran, Guido Davidzon, Gabriel Kennedy, Elizabeth C. Mormino

Publikováno v: Eur J Nucl Med Mol Imaging

PURPOSE: While sampled or short-frame realizations have shown the potential power of deep learning to reduce radiation dose for PET images, evidence in true injected ultra-low-dose cases is lacking. Therefore, we evaluated deep learning enhancement u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472b94bbed1b4b74be36d1dddb4473d0
https://doi.org/10.1007/s00259-020-05151-9

Hippocampal subfield imaging and fractional anisotropy show parallel changes in Alzheimer's disease tau progression using simultaneous tau‐PET/MRI at 3T

Autor: Michael Zeineh, Jessa B. Castillo, Bin Shen, Gustavo Chau, Emily Carmen Azevedo, Tyler N. Toueg, Phillip DiGiacomo, Mackenzie L. Carlson, Michelle L. James, Nicole Mouchawar, Elizabeth C. Mormino, Mohammad Mehdi Khalighi, Greg Zaharchuk

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Introduction Alzheimer's disease (AD) is the most common form of dementia, characterized primarily by abnormal aggregation of two proteins, tau and amyloid beta. We assessed tau pathology and white matter connectivity changes in subfields of the hipp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86dcb26a0a88ea2b99e43585a289cc4
https://doi.org/10.1002/dad2.12218

Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease

Autor: Michelle S. Swarovski, Tammy Tran, Alexandra N. Trelle, Brian K. Rutt, Tyler N. Toueg, Manasi Jayakumar, Edward N. Wilson, Ayesha Nadiadwala, Katrin I. Andreasson, Valerie A. Carr, Carolyn A. Fredericks, Marc B. Harrison, Wanjia Guo, Elizabeth C. Mormino, Nicole K Corso, Scott A Guerin, Monica K Thieu, Anthony D. Wagner, Madison P Hunt, Frederick T. Chin, Jeffrey D. Bernstein, Geoffrey A. Kerchner, Natalie J Tanner, Guido Davidzon, Divya Channappa, Anna M. Khazenzon, Sharon J. Sha, Celia P Litovsky, Jacob N. Hall, Gayle K. Deutsch

Publikováno v: Neurology

ObjectiveTo determine whether memory tasks with demonstrated sensitivity to hippocampal function can detect variance related to preclinical Alzheimer disease (AD) biomarkers, we examined associations between performance in 3 memory tasks and CSF β-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de32a620b86e01cefd11cc66e13ba547
https://pubmed.ncbi.nlm.nih.gov/33408146