Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Tyler N Starr"'
Autor:
Felicitas Ruiz, William B Foreman, Michelle Lilly, Viren A Baharani, Delphine M Depierreux, Vrasha Chohan, Ashley L Taylor, Jamie Guenthoer, Duncan Ralph, Frederick A Matsen Iv, Helen Y Chu, Paul D Bieniasz, Marceline Côté, Tyler N Starr, Julie Overbaugh
Publikováno v:
PLoS Pathogens, Vol 20, Iss 10, p e1012650 (2024)
The recurring spillover of pathogenic coronaviruses and demonstrated capacity of sarbecoviruses, such SARS-CoV-2, to rapidly evolve in humans underscores the need to better understand immune responses to this virus family. For this purpose, we charac
Externí odkaz:
https://doaj.org/article/f08e20ec5af34d6eb3397466d09da5d1
Publikováno v:
eLife, Vol 12 (2024)
A protein’s genetic architecture – the set of causal rules by which its sequence produces its functions – also determines its possible evolutionary trajectories. Prior research has proposed that the genetic architecture of proteins is very comp
Externí odkaz:
https://doaj.org/article/322993c1c1ed478d814735598c95cd5f
Autor:
Ashley L Taylor, Tyler N Starr
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011901 (2023)
Substitutions that fix between SARS-CoV-2 variants can transform the mutational landscape of future evolution via epistasis. For example, large epistatic shifts in mutational effects caused by N501Y underlied the original emergence of Omicron, but wh
Externí odkaz:
https://doaj.org/article/9704fc391ee34a4ea274a5d68982632a
Autor:
Alief Moulana, Thomas Dupic, Angela M Phillips, Jeffrey Chang, Anne A Roffler, Allison J Greaney, Tyler N Starr, Jesse D Bloom, Michael M Desai
Publikováno v:
eLife, Vol 12 (2023)
The Omicron BA.1 variant of SARS-CoV-2 escapes convalescent sera and monoclonal antibodies that are effective against earlier strains of the virus. This immune evasion is largely a consequence of mutations in the BA.1 receptor binding domain (RBD), t
Externí odkaz:
https://doaj.org/article/af2ba229e801450dbdffb38ffb9301ac
Autor:
Tyler N Starr, Allison J Greaney, Cameron M Stewart, Alexandra C Walls, William W Hannon, David Veesler, Jesse D Bloom
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010951 (2022)
SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD) that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep mutational scanning prospectively characterizes the impacts of mutations on thes
Externí odkaz:
https://doaj.org/article/935a02fbd2d6495d8f961be0fd3e02fe
Autor:
Allison J Greaney, Rachel T Eguia, Tyler N Starr, Khadija Khan, Nicholas Franko, Jennifer K Logue, Sandra M Lord, Cate Speake, Helen Y Chu, Alex Sigal, Jesse D Bloom
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010592 (2022)
Exposure histories to SARS-CoV-2 variants and vaccinations will shape the specificity of antibody responses. To understand the specificity of Delta-elicited antibody immunity, we characterize the polyclonal antibody response elicited by primary or mR
Externí odkaz:
https://doaj.org/article/673cd94aaa38462099996f44aeda4423
Autor:
Allison J Greaney, Tyler N Starr, Rachel T Eguia, Andrea N Loes, Khadija Khan, Farina Karim, Sandile Cele, John E Bowen, Jennifer K Logue, Davide Corti, David Veesler, Helen Y Chu, Alex Sigal, Jesse D Bloom
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010248 (2022)
Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it is unknown if antibodies elicited by infection with these variants target the same or different regions of the viral spike as antibodies elicited by earlier vira
Externí odkaz:
https://doaj.org/article/47294b3432084a629a2f2e376fdff936
Autor:
Ariën Schiepers, Marije F. L. van ’t Wout, Allison J. Greaney, Trinity Zang, Hiromi Muramatsu, Paulo J. C. Lin, Ying K. Tam, Luka Mesin, Tyler N. Starr, Paul D. Bieniasz, Norbert Pardi, Jesse D. Bloom, Gabriel D. Victora
Publikováno v:
Nature. 615:482-489
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::973ba7f5a918b2ef03fba3e3c82282e1
https://doi.org/10.1038/s41586-023-05715-3
https://doi.org/10.1038/s41586-023-05715-3
Autor:
Tyler N. Starr, Allison J. Greaney, William W. Hannon, Andrea N. Loes, Kevin Hauser, Josh R. Dillen, Elena Ferri, Ariana Ghez Farrell, Bernadeta Dadonaite, Matthew McCallum, Kenneth A. Matreyek, Davide Corti, David Veesler, Gyorgy Snell, Jesse D. Bloom
Publikováno v:
Science. 377:420-424
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved variants with substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin-converting enzyme 2 (ACE2) receptor and recognition by antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1c8a39dffec354987cb14b4eeb5686
https://doi.org/10.1126/science.abo7896
https://doi.org/10.1126/science.abo7896
A protein’s genetic architecture – the set of causal rules by which its sequence determines its specific functions – also determines the functional impacts of mutations and the protein’s evolutionary potential. Prior research has proposed tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34ee00e9b455f0351a7217e3babe9a13
https://doi.org/10.1101/2023.04.19.537271
https://doi.org/10.1101/2023.04.19.537271
