Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Tyler N Starr"'
Publikováno v:
eLife, Vol 12 (2024)
A protein’s genetic architecture – the set of causal rules by which its sequence produces its functions – also determines its possible evolutionary trajectories. Prior research has proposed that the genetic architecture of proteins is very comp
Externí odkaz:
https://doaj.org/article/322993c1c1ed478d814735598c95cd5f
Autor:
Chengzi I. Kaku, Tyler N. Starr, Panpan Zhou, Haley L. Dugan, Paul Khalifé, Ge Song, Elizabeth R. Champney, Daniel W. Mielcarz, James C. Geoghegan, Dennis R. Burton, Raiees Andrabi, Jesse D. Bloom, Laura M. Walker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Understanding the longitudinal dynamics of antibody immunity following heterologous SAR-CoV-2 breakthrough infection will inform the development of next-generation vaccines. Here, we track SARS-CoV-2 receptor binding domain (RBD)-specific an
Externí odkaz:
https://doaj.org/article/37c3f7bee51f4b23946f80718a893c6d
Autor:
Ashley L Taylor, Tyler N Starr
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011901 (2023)
Substitutions that fix between SARS-CoV-2 variants can transform the mutational landscape of future evolution via epistasis. For example, large epistatic shifts in mutational effects caused by N501Y underlied the original emergence of Omicron, but wh
Externí odkaz:
https://doaj.org/article/9704fc391ee34a4ea274a5d68982632a
Autor:
Alief Moulana, Thomas Dupic, Angela M. Phillips, Jeffrey Chang, Serafina Nieves, Anne A. Roffler, Allison J. Greaney, Tyler N. Starr, Jesse D. Bloom, Michael M. Desai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Evolution of the SARS-CoV-2 spike protein is likely driven by many factors, including immune escape and receptor binding. Here, by measuring the binding affinity of more than 30,000 variants of the SARS-CoV-2 RBD to its receptor ACE2, Moulana et al.
Externí odkaz:
https://doaj.org/article/17b039ea8511422d98f2853e4e15fe44
Autor:
Alief Moulana, Thomas Dupic, Angela M Phillips, Jeffrey Chang, Anne A Roffler, Allison J Greaney, Tyler N Starr, Jesse D Bloom, Michael M Desai
Publikováno v:
eLife, Vol 12 (2023)
The Omicron BA.1 variant of SARS-CoV-2 escapes convalescent sera and monoclonal antibodies that are effective against earlier strains of the virus. This immune evasion is largely a consequence of mutations in the BA.1 receptor binding domain (RBD), t
Externí odkaz:
https://doaj.org/article/af2ba229e801450dbdffb38ffb9301ac
Autor:
Tyler N Starr, Allison J Greaney, Cameron M Stewart, Alexandra C Walls, William W Hannon, David Veesler, Jesse D Bloom
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010951 (2022)
SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD) that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep mutational scanning prospectively characterizes the impacts of mutations on thes
Externí odkaz:
https://doaj.org/article/935a02fbd2d6495d8f961be0fd3e02fe
Autor:
Allison J. Greaney, Tyler N. Starr, Christopher O. Barnes, Yiska Weisblum, Fabian Schmidt, Marina Caskey, Christian Gaebler, Alice Cho, Marianna Agudelo, Shlomo Finkin, Zijun Wang, Daniel Poston, Frauke Muecksch, Theodora Hatziioannou, Paul D. Bieniasz, Davide F. Robbiani, Michel C. Nussenzweig, Pamela J. Bjorkman, Jesse D. Bloom
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Emerging SARS-CoV-2 mutants may escape neutralization by antibodies. Here, the authors use deep mutational scanning to identify mutations in the RBD that escape human monoclonal antibodies or convalescent plasmas.
Externí odkaz:
https://doaj.org/article/ed99a3d89b4343beb0ebcb8680884099
Autor:
Allison J Greaney, Rachel T Eguia, Tyler N Starr, Khadija Khan, Nicholas Franko, Jennifer K Logue, Sandra M Lord, Cate Speake, Helen Y Chu, Alex Sigal, Jesse D Bloom
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010592 (2022)
Exposure histories to SARS-CoV-2 variants and vaccinations will shape the specificity of antibody responses. To understand the specificity of Delta-elicited antibody immunity, we characterize the polyclonal antibody response elicited by primary or mR
Externí odkaz:
https://doaj.org/article/673cd94aaa38462099996f44aeda4423
Autor:
Allison J Greaney, Tyler N Starr, Rachel T Eguia, Andrea N Loes, Khadija Khan, Farina Karim, Sandile Cele, John E Bowen, Jennifer K Logue, Davide Corti, David Veesler, Helen Y Chu, Alex Sigal, Jesse D Bloom
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010248 (2022)
Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it is unknown if antibodies elicited by infection with these variants target the same or different regions of the viral spike as antibodies elicited by earlier vira
Externí odkaz:
https://doaj.org/article/47294b3432084a629a2f2e376fdff936
Autor:
Wen Su, Sin Fun Sia, Aaron J. Schmitz, Traci L. Bricker, Tyler N. Starr, Allison J. Greaney, Jackson S. Turner, Bassem M. Mohammed, Zhuoming Liu, Ka Tim Choy, Tamarand L. Darling, Astha Joshi, Ka Man Cheng, Alvina Y. L. Wong, Houda H. Harastani, John M. Nicholls, Sean P. J. Whelan, Jesse D. Bloom, Hui-Ling Yen, Ali H. Ellebedy, Adrianus C. M. Boon
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of convalescent-
Externí odkaz:
https://doaj.org/article/59017aa8fbfc49cca3569388d8d7b51e