Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tyler McLaughlin"'
Autor:
R. Tyler McLaughlin, Maansi Asthana, Marc Di Meo, Michele Ceccarelli, Howard J. Jacob, David L. Masica
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract Accurately identifying somatic mutations is essential for precision oncology and crucial for calculating tumor-mutational burden (TMB), an important predictor of response to immunotherapy. For tumor-only variant calling (i.e., when the cance
Externí odkaz:
https://doaj.org/article/c5b2cf3cf2c544e188a700aec68c1107
Autor:
Edward B. Samson, David S. Tsao, Jan Zimak, R. Tyler McLaughlin, Nicholaus J. Trenton, Emily M. Mace, Jordan S. Orange, Volker Schweikhard, Michael R. Diehl
Publikováno v:
Biology Open, Vol 6, Iss 6, Pp 785-799 (2017)
IQGAP1 is a large, multi-domain scaffold that helps orchestrate cell signaling and cytoskeletal mechanics by controlling interactions among a spectrum of receptors, signaling intermediates, and cytoskeletal proteins. While this coordination is known
Externí odkaz:
https://doaj.org/article/f292250d8fa2446fbe40ac69e66c7c58
Membrane and Actin Tethering Transitions Help IQGAP1 Coordinate GTPase and Lipid Messenger Signaling
Autor:
Emily M. Mace, Satya K. Bellamkonda, R. Tyler McLaughlin, Volker Schweikhard, Michael R. Diehl, Alexandra Rodzinski, Nicholaus J. Trenton, Jordan S. Orange, David S. Tsao
Publikováno v:
Biophys J
The coordination of lipid messenger signaling with cytoskeletal regulation is central to many organelle-specific regulatory processes. This coupling often depends on the function of multidomain scaffolds that orchestrate transient interactions among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb3892c5a58bb3badfb267b1bdbcd51
https://doi.org/10.1016/j.bpj.2019.12.023
https://doi.org/10.1016/j.bpj.2019.12.023
Autor:
R. Tyler McLaughlin, Maansi Asthana, Marc Di Meo, Michele Ceccarelli, Howard J. Jacob, David L. Masica
In precision oncology, reliable identification of tumor-specific DNA mutations requires sequencing tumor DNA and non-tumor DNA (so-called “matched normal”) from the same patient. The normal sample allows researchers to distinguish acquired (somat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::345acb48e1c2ac0ca1233c16414499f4
https://doi.org/10.1101/2021.12.07.471513
https://doi.org/10.1101/2021.12.07.471513
Autor:
Weilong Zhao, Robert Tyler McLaughlin, David Masica, Erik Huntzicker, Tamar Uziel, Michael Flister, Alex Bankovich, Josue Samayoa, Dorothy French, Xi Zhao
Publikováno v:
Journal of Clinical Oncology. 40:8577-8577
8577 Background: Predicting variable therapeutic responses that are driven by the genetic and transcriptomic heterogeneity of Small Cell Lung Cancer (SCLC) offers an opportunity for implementing precision therapies within the cancer cells and tumor m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb91b75da60aa4db10968009daa723a6
https://doi.org/10.1200/jco.2022.40.16_suppl.8577
https://doi.org/10.1200/jco.2022.40.16_suppl.8577
Autor:
Stacie L. Lambert, Chun Zhang, Claire Guo, Tolga Turan, David L. Masica, Stefan Englert, Yuni Fang, James Sheridan, Robert Tyler McLaughlin, Catherine Tribouley, Greg Vosganian, Daniel Afar
Publikováno v:
Journal of immunotherapy (Hagerstown, Md. : 1997). 45(3)
Budigalimab, a novel anti-PD-1 monoclonal antibody, demonstrated efficacy and biomarker pharmacodynamics in patients with head and neck squamous cell carcinoma (HNSCC) or non-small cell lung cancer (NSCLC) consistent with those reported by other PD-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44be33d2f77a49e00691fafda62a67b0
https://pubmed.ncbi.nlm.nih.gov/35034046
https://pubmed.ncbi.nlm.nih.gov/35034046
Autor:
Michael R. Diehl, Nicholaus J. Trenton, R. Tyler McLaughlin, Volker Schweikhard, Jordan S. Orange, Emily M. Mace, David S. Tsao, Satya K. Bellamkonda
The coordination of lipid messenger signaling with cytoskeletal regulation is central to many organelle-specific signaling and regulatory processes. While central to many aspects of cell physiology, this coupling often depends on the function of mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1dc10057021856e6662d12d54e8e46
Publikováno v:
Soft matter. 12(1)
Major cellular processes are supported by various biomolecular motors that usually operate together as teams. We present an overview of the collective dynamics of processive cytokeletal motor proteins based on recent experimental and theoretical inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb9c0e9f87b852466602473cbac62bd
https://pubmed.ncbi.nlm.nih.gov/26444155
https://pubmed.ncbi.nlm.nih.gov/26444155
Publikováno v:
Biophysical Journal. 112:431a
IQGAP1 is a large, multi-domain scaffold that helps orchestrate cell signaling and cytoskeletal mechanics by controlling interactions among a spectrum of receptors, signaling intermediates, and cytoskeletal proteins. While this coordination is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2980b2cc86ac7e6276a4aab86de4ed8
https://doi.org/10.1016/j.bpj.2016.11.2302
https://doi.org/10.1016/j.bpj.2016.11.2302