Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tyler Matheny"'
Autor:
Amy E. Campbell, Michael C. Dyle, Roberto Albanese, Tyler Matheny, Kavitha Sudheendran, Michael A. Cortázar, Thomas Forman, Rui Fu, Austin E. Gillen, Marvin H. Caruthers, Stephen N. Floor, Lorenzo Calviello, Sujatha Jagannathan
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112642- (2023)
Summary: Nonsense-mediated RNA decay (NMD) degrades transcripts carrying premature termination codons. NMD is thought to prevent the synthesis of toxic truncated proteins. However, whether loss of NMD results in widespread production of truncated pro
Externí odkaz:
https://doaj.org/article/df0dd2523a6149e2baba95596b1500ad
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Recent studies proposed that m6A modification in mammalian mRNAs increases their recruitment to stress granule. However, here the authors observed that m6A modification has a limited effect on mRNA entry into stress granules.
Externí odkaz:
https://doaj.org/article/dd84e5ce91e34343892c384aea652718
Publikováno v:
eLife, Vol 5 (2016)
Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when translation initiation is limited and contain a biphasic structure with stable core structures surrounded by a less concentrated shell. The order of assembly and disas
Externí odkaz:
https://doaj.org/article/f21de15b53434d278f531a0c46d730c7
Autor:
Arely V. Diaz, Tyler Matheny, Daniel Stephenson, Travis Nemkov, Angelo D’Alessandro, Tânia Reis
Publikováno v:
bioRxiv
Metabolism in males and females is distinct. Differences are usually linked to sexual reproduction, with circulating signals (e.g. hormones) playing major roles. By contrast, sex differences prior to sexual maturity and intrinsic to individual metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2edb3637c29fba1d3d2d895290e9e5
https://europepmc.org/articles/PMC9949119/
https://europepmc.org/articles/PMC9949119/
Publikováno v:
Neurotherapeutics
This review summarizes the pathogenic mechanisms that underpin the monogenic epilepsies and discusses the potential of novel precision therapeutics to treat these disorders. Pathogenic mechanisms of epilepsy include recessive (null alleles), haploins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1718851b8845eaed82dad39f9c1d7d4
https://doi.org/10.1007/s13311-021-01137-z
https://doi.org/10.1007/s13311-021-01137-z
Autor:
Yen-Chen Lin, John D. Leszyk, Evangelos Kiskinis, John Landers, Salome Funes, Lawrence J. Hayward, Scott A. Shaffer, Maeve Tischbein, Kevin P. Kenna, Roy Parker, Tyler Matheny, Desiree M. Baron, Daryl A. Bosco, David Santos, Katherine V. Gall
Publikováno v:
Hum Mol Genet
Aberrant translational repression is a feature of multiple neurodegenerative diseases. The association between disease-linked proteins and stress granules further implicates impaired stress responses in neurodegeneration. However, our knowledge of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64b7b5bd8a7d11f838257d91da039e6
https://doi.org/10.1093/hmg/ddz048
https://doi.org/10.1093/hmg/ddz048
Autor:
Amy E. Campbell, Michael C. Dyle, Lorenzo Calviello, Tyler Matheny, Kavitha Sudheendran, Michael A. Cortazar, Thomas Forman, Rui Fu, Austin E. Gillen, Marvin H. Caruthers, Stephen N. Floor, Sujatha Jagannathan
Nonsense-mediated RNA decay (NMD) is a surveillance mechanism that degrades both canonical and aberrant transcripts carrying premature translation termination codons. NMD is thought to have evolved to prevent the synthesis of toxic truncated proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47d1e35295b3d46515ea341d82d00715
https://doi.org/10.1101/2021.06.28.450189
https://doi.org/10.1101/2021.06.28.450189
Publikováno v:
Nature communications. 13(1)
The presence of the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e43957e8ad230c26fe8a956a3954953
https://pubmed.ncbi.nlm.nih.gov/35768440
https://pubmed.ncbi.nlm.nih.gov/35768440
Publikováno v:
RNA
Stress granules (SGs) are stress-induced RNA–protein assemblies formed from a complex transcriptome of untranslating ribonucleoproteins (RNPs). Although RNAs can be either enriched or depleted from SGs, the rules that dictate RNA partitioning into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3070a3188adaf1d21b20974c1f1f88da
https://pubmed.ncbi.nlm.nih.gov/33199441
https://pubmed.ncbi.nlm.nih.gov/33199441
Publikováno v:
Mol Cell Biol
The eukaryotic cytosol contains multiple RNP granules, including P-bodies and stress granules. Three different methods have been used to describe the transcriptome of stress granules or P-bodies, but how these methods compare and how RNA partitioning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2eb6a2f827643dfda68146ff78c0428
https://doi.org/10.1128/mcb.00313-19
https://doi.org/10.1128/mcb.00313-19