Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tyler M. Lu"'
Autor:
Anjali Trivedi, Tyler M. Lu, Barbara Summers, Kihwan Kim, Alexander J. Rhee, Sean Houghton, Derek E. Byers, Raphaël Lis, Hasina Outtz Reed
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The lymphatic vasculature regulates lung homeostasis through drainage of fluid and trafficking of immune cells and plays a key role in the response to lung injury in several disease states. We have previously shown that lymphatic dysfunction occurs e
Externí odkaz:
https://doaj.org/article/0f6ab31e9e974b9483cfdb3150dfc7e5
Autor:
Tyler M. Lu, José Gabriel Barcia Durán, Sean Houghton, Shahin Rafii, David Redmond, Raphaël Lis
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Brain microvascular endothelial cells (BMECs) possess unique properties that are crucial for many functions of the blood-brain-barrier (BBB) including maintenance of brain homeostasis and regulation of interactions between the brain and immune system
Externí odkaz:
https://doaj.org/article/66915dd315d74b8bba74f51c4754f1de
Autor:
Jesus M. Gomez-Salinero, Tomer Itkin, Sean Houghton, Chaitanya Badwe, Yang Lin, Viktoria Kalna, Neil Dufton, Claire R. Peghaire, Masataka Yokoyama, Matthew Wingo, Tyler M. Lu, Ge Li, Jenny Zhaoying Xiang, Yen-Michael Sheng Hsu, David Redmond, Ryan Schreiner, Graeme M. Birdsey, Anna M. Randi, Shahin Rafii
Publikováno v:
Nat Cardiovasc Res
Current dogma dictates that, during adulthood, endothelial cells (ECs) are locked in an immutable stable homeostatic state. By contrast, herein we show that maintenance of EC fate and function are linked and active processes, which depend on the cons
Autor:
Etienne Meylan, David R. Jones, Navneet Narula, Jinxiang Dai, Shahin Rafii, Yuan Liu, Henrik Molina, Irene Casanova-Salas, Han Sang Kim, Irina Matei, David J. Pisapia, Alberto Benito-Martin, Quincey LaPlant, Joshua K. Sabari, Milica Tesic Mark, David Lyden, Candia M. Kenific, Daniela Freitas, Sandra J. Shin, Xinran Jiang, Nasser K. Altorki, Yonathan Ararso, Katharine Offer, Paula S. Ginter, Brian D. Dill, Loïc Steiner, Vinagolu K. Rajasekhar, Brunilde Gril, Huajuan Wang, Maria de Sousa, Gonçalo Rodrigues, Chaitanya R. Badwe, Héctor Peinado, Shizhen Emily Wang, Tyler M. Lu, Bruno Costa-Silva, Haiying Zhang, Patricia S. Steeg, Cyrus M. Ghajar, Ayuko Hoshino, Weston Buehring, John H. Healey, Charles M. Rudin, Peter R. Oxley, Linda Bojmar, Ilana Scandariato, Jacqueline Bromberg
Publikováno v:
Nature cell biology, vol 21, iss 11
Nat Cell Biol
Nat Cell Biol
The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic coloniz
Autor:
Tyler M. Lu, Shahin Rafii, Raphael Lis, José Gabriel Barcia Durán, David Redmond, Ryan Schreiner, Fuqiang Geng, Jenny Xiang, Sean Houghton
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Jak3 is the only non-promiscuous member of the Jak family of secondary messengers. Studies to date have focused on understanding and targeting the cell-autonomous role of Jak3 in immunity, while functional Jak3 expression outside the hematopoietic sy
Autor:
Charles J. Gatt, Salim A. Ghodbane, Michael G. Dunn, Jay M. Patel, Andrzej Brzezinski, Tyler M. Lu
Publikováno v:
Journal of Biomedical Materials Research Part B: Applied Biomaterials. 107:2457-2465
The menisci transmit load by increasing the contact area and decreasing peak contact stresses on the articular surfaces. Meniscal lesions are among the most common orthopedic injuries, and resulting meniscectomies are associated with adverse polycapr
Publikováno v:
Nat Protoc
The ability to generate haematopoietic stem cells in vitro would have immeasurable impact upon many areas of clinical practice, including trauma, cancer, and congenital disease. In this protocol, we describe a stepwise approach to convert adult murin
Autor:
Andrew Sproul, Amanda M. Snead, Raphael Lis, Tyler M. Lu, Andrew P. Minotti, Dritan Agalliu, David Redmond, Lorenz Studer, Shahin Rafii, Howard A. Fine, Sean Houghton, José Gabriel Barcia Durán, Zev Rosenwaks, Tarig Magdeldin, Duc-Huy T. Nguyen, Jenny Xiang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Human PSC-derived iBMECs have been generated to study disease mechanisms and drug development for neurological disorders. However, their full transcriptomic characterization is unclear, which could result in inaccurate physiological stud
Autor:
Thangamani Muthukumar, Sina Y. Rabbany, Mary E. Choi, Edward Daniel, Jenny Xiang, Tyler M. Lu, Annarita Di Lorenzo, David M. Barry, Balvir Kunar, Tuo Zhang, Elizabeth A. McMillan, Raphael Lis, Shahin Rafii, Angara Sureshbabu, David Redmond, Masataka Yokoyama, Jesus M. Gomez-Salinero, Ondine Cleaver
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Although kidney parenchymal tissue can be generated in vitro, reconstructing the complex vasculature of the kidney remains a daunting task. The molecular pathways that specify and sustain functional, phenotypic and structural heterogeneity of the kid
Autor:
Zev Rosenwaks, Tyler M. Lu, Jenny Xiang, Amanda M. Snead, Shahin Rafii, Andrew Sproul, Howard A. Fine, Duc-Huy T. Nguyen, Tarig Magdeldin, Raphael Lis, David Redmond, Dritan Agalliu, Koji Shido
Brain microvascular endothelial cells (BMECs) possess unique properties underlying the blood-brain-barrier (BBB), that are crucial for homeostatic brain functions and interactions with the immune system. Modulation of BBB function is essential for tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87de880313651b1f5619df7df4c397c8