Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tyler M. Foley"'
Autor:
Nicholas M. Mohr, Eliezer Santos Leon, Jestin N. Carlson, Brian Driver, Anusha Krishnadasan, Karisa K. Harland, Patrick Ten Eyck, William R. Mower, Tyler M. Foley, Kelli Wallace, L. Clifford McDonald, Preeta K. Kutty, Scott Santibanez, David A. Talan
Publikováno v:
Annals of Emergency Medicine. 81:145-157
To describe endotracheal intubation practices in emergency departments by staff intubating patients early in the coronavirus disease 2019 (COVID-19) pandemic.Multicenter prospective cohort study of endotracheal intubations conducted at 20 US academic
Supplementary Figure S1 from MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers
Autor:
Dustin A. Deming, Melissa C. Skala, Michael A. Newton, Kristina A. Matkowskyj, Paraic A. Kenny, Benjamin M. Parsons, Kayla K. Lemmon, Mark E. Burkard, Linda Clipson, Rebecca A. DeStefanis, Gioia Chengcheng Sha, Demetra P. Korkos, Mitchell G. Depke, Dana R. Van De Hey, Alexander E. Yueh, Tyler M. Foley, Cheri A. Pasch, Jeremy D. Kratz, Peter F. Favreau, Susan N. Payne, Stephanie L. Fricke
Supplementary Figure S1 presents the viability of SW48 and SW48PK cells after treatment with BEZ235 and TAK-228 at the 100-400nM concentrations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3797d51c82d44138bbd5766b7be6a207
https://doi.org/10.1158/1535-7163.22507717.v1
https://doi.org/10.1158/1535-7163.22507717.v1
Autor:
Dustin A. Deming, Michael A. Newton, Kristina A. Matkowskyj, Molly E Maher, Linda Clipson, Demetra P Korkos, Dana R Van De Hey, Alex E. Yueh, Cheri A. Pasch, Susan N. Payne, Tyler M Foley
S1. AP spheroids were plated and allowed to mature for 48 hours. S2. To address the issue of potentially slower growth of the spheres with the largest initial sizes, a change-point analysis was performed. S3. AP mice were treated with control (A) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b40b59770a6d2023987e8d876e86d4
https://doi.org/10.1158/1541-7786.22515181
https://doi.org/10.1158/1541-7786.22515181
Autor:
Dustin A. Deming, Melissa C. Skala, Michael A. Newton, Kristina A. Matkowskyj, Paraic A. Kenny, Benjamin M. Parsons, Kayla K. Lemmon, Mark E. Burkard, Linda Clipson, Rebecca A. DeStefanis, Gioia Chengcheng Sha, Demetra P. Korkos, Mitchell G. Depke, Dana R. Van De Hey, Alexander E. Yueh, Tyler M. Foley, Cheri A. Pasch, Jeremy D. Kratz, Peter F. Favreau, Susan N. Payne, Stephanie L. Fricke
PIK3CA mutations are common in clinical molecular profiling, yet an effective means to target these cancers has yet to be developed. MTORC1 inhibitors are often used off-label for patients with PIK3CA mutant cancers with only limited data to support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61eef4938e53e1487200610ced459f4f
https://doi.org/10.1158/1535-7163.c.6538765.v1
https://doi.org/10.1158/1535-7163.c.6538765.v1
Autor:
Alexander E Yueh, Susan N Payne, Alyssa A Leystra, Dana R Van De Hey, Tyler M Foley, Cheri A Pasch, Linda Clipson, Kristina A Matkowskyj, Dustin A Deming
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148730 (2016)
The phosphoinositide 3-kinase (PI3K) signaling pathway is critical for multiple important cellular functions, and is one of the most commonly altered pathways in human cancers. We previously developed a mouse model in which colon cancers were initiat
Externí odkaz:
https://doaj.org/article/43d47cd50a744f7b938ac68fd1de464b
Autor:
Molly Maher, Cheri A. Pasch, Demetra P. Korkos, Dana R. Van De Hey, Alex E. Yueh, Linda Clipson, Dustin A. Deming, Susan N. Payne, Kristina A. Matkowskyj, Tyler M. Foley, Michael A. Newton
Publikováno v:
Molecular Cancer Research. 15:317-327
Therapeutic targeting of the PI3K pathway is an active area of research in multiple cancer types, including breast and endometrial cancers. This pathway is commonly altered in cancer and plays an integral role in numerous vital cellular functions. Mu
Autor:
Tyler M, Foley, Susan N, Payne, Cheri A, Pasch, Alex E, Yueh, Dana R, Van De Hey, Demetra P, Korkos, Linda, Clipson, Molly E, Maher, Kristina A, Matkowskyj, Michael A, Newton, Dustin A, Deming
Publikováno v:
Molecular cancer research : MCR. 15(3)
Therapeutic targeting of the PI3K pathway is an active area of research in multiple cancer types, including breast and endometrial cancers. This pathway is commonly altered in cancer and plays an integral role in numerous vital cellular functions. Mu
Autor:
Tyler M. Foley, Dustin A. Deming, Susan N. Payne, Cheri A. Pasch, Kristina A. Matkowskyj, Alexander E. Yueh, Alyssa A. Leystra, Dana R. Van De Hey, Linda Clipson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 2, p e0148730 (2016)
PLoS ONE, Vol 11, Iss 2, p e0148730 (2016)
The phosphoinositide 3-kinase (PI3K) signaling pathway is critical for multiple important cellular functions, and is one of the most commonly altered pathways in human cancers. We previously developed a mouse model in which colon cancers were initiat
Autor:
Tyler M. Foley, Nguyen H. Tran, Cheri A. Pasch, Kristina A. Matkowskyj, Susan N. Payne, Alexander E. Yueh, Alyssa A. Leystra, Molly Maher, Dustin A. Deming, D R Van De Hey, J J Jeffrey, Linda Clipson
Publikováno v:
Oncogenesis
Aberrations in the phosphoinositide 3-kinase (PI3K) signaling pathway have a key role in the pathogenesis of numerous cancers by altering cell growth, metabolism, proliferation and apoptosis. Interest in targeting the PI3K signaling cascade continues
Autor:
Dana R. Van De Hey, Tyler M. Foley, Demetra P. Korkos, Stephanie L. Fricke, Dustin A. Deming, Linda Clipson, Cheri A. Pasch, Alexander E. Yueh, Susan N. Payne
Publikováno v:
Cancer Research. 76:385-385
BACKGROUND Colorectal cancer (CRC) remains the second leading cause of cancer-related deaths in the United States. Several key mutations in CRC include APC (80%), TP53 (50%), and PIK3CA (20-30%). Mutations in the PIK3CA gene, resulting in a constitut