Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Tyler M Earnest"'
Autor:
Marian Breuer, Tyler M Earnest, Chuck Merryman, Kim S Wise, Lijie Sun, Michaela R Lynott, Clyde A Hutchison, Hamilton O Smith, John D Lapek, David J Gonzalez, Valérie de Crécy-Lagard, Drago Haas, Andrew D Hanson, Piyush Labhsetwar, John I Glass, Zaida Luthey-Schulten
Publikováno v:
eLife, Vol 8 (2019)
JCVI-syn3A, a robust minimal cell with a 543 kbp genome and 493 genes, provides a versatile platform to study the basics of life. Using the vast amount of experimental information available on its precursor, Mycoplasma mycoides capri, we assembled a
Externí odkaz:
https://doaj.org/article/8a4a0da0c3184384beb1ab8154468210
Autor:
John A Cole, Joseph R Peterson, Tyler M Earnest, Michael J Hallock, Daniel J Cook, Eduardo Braun, Anu Antony, John R Pfeiffer, Tushar Pandey
Publikováno v:
Cancer Research. 82:P1-08
Background: Breast Cancer (BC) patients exhibit a wide variety of responses to neoadjuvant chemotherapy (NACT). This is driven by factors both intrinsic (e.g., mutations, dysregulation, metabolic reprogramming) and extrinsic (e.g., nutrient/drug perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94de88ce9533cba958245dcb573cc3f8
https://doi.org/10.1158/1538-7445.sabcs21-p1-08-31
https://doi.org/10.1158/1538-7445.sabcs21-p1-08-31
Autor:
JR Pfeiffer, Joseph R. Peterson, Frederick Howard, Tyler M. Earnest, Tushar Pandey, Gong He, Rita Nanda
Publikováno v:
Cancer Research. 82:P5-13
Background Immunotherapy (IO) is expected to become a part of standard neoadjuvant therapy for early-stage, triple-negative breast cancer. However, only a minority of patients benefit from the addition of IO to standard neoadjuvant chemotherapy (NACT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3d7a2f3eb77a4dcdeca7e39c6acf82c
https://doi.org/10.1158/1538-7445.sabcs21-p5-13-34
https://doi.org/10.1158/1538-7445.sabcs21-p5-13-34
Publikováno v:
Cancer Research. 82:P4-06
Background Dynamic contrast-enhanced (DCE) MRI is commonly used for diagnosis and treatment planning of cancers. Its main use is the identification of tumors in soft tissues, where the tumor progression-induced angiogenic changes result in leaky vasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c44dba1b48d35d4f4547768b5c39a97e
https://doi.org/10.1158/1538-7445.sabcs21-p4-06-02
https://doi.org/10.1158/1538-7445.sabcs21-p4-06-02
Autor:
Amanda Parker, Tyler M. Earnest, Arda Pekis, Vignesh Kannan, Joseph Peterson, John A. Cole, Anuja K. Antony, Daniel Cook
Publikováno v:
Cancer Research. 83:P4-02
Background: Surgical oncologists currently rely on 2D image slices, such as those from mammograms, to assess the locations and extents of their patients’ breast cancer tumors. In order to accurately evaluate the potential success of various surgica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60e1048c7250ee7bdf195140b5fead36
https://doi.org/10.1158/1538-7445.sabcs22-p4-02-29
https://doi.org/10.1158/1538-7445.sabcs22-p4-02-29
Autor:
Tushar Pandey, Joseph R. Peterson, Katherine Ritchie, Eduardo Braun, Michael J. Hallock, Tyler M. Earnest, John A. Cole
Publikováno v:
Cancer Research. 80:P1-06
Introduction Intrinsic breast cancer subtypes (e.g., Normal-like, Luminal A/B, HER2-enriched, Triple Negative) vary in their responsiveness to neoadjuvant chemotherapy (NACT) and are associated with differing long-term prognosis. Expression dis-regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::297cf1214e9ba542c9ade94df58c8b1c
https://doi.org/10.1158/1538-7445.sabcs19-p1-06-03
https://doi.org/10.1158/1538-7445.sabcs19-p1-06-03
Publikováno v:
Cancer Research. 80:P1-06
Background A single neuron cannot think, just as a single hepatocyte cannot filter blood. The functions of the tissues that make up our bodies are emergent, depending on both their constituent cells' internal biology, as well as how they interact wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0b1d8b63066788049806ed39723a349
https://doi.org/10.1158/1538-7445.sabcs19-p1-06-04
https://doi.org/10.1158/1538-7445.sabcs19-p1-06-04
Autor:
Nicole Liadis, Tyler M Earnest, Eduardo Braun, Anu K. Antony, Micahel J Hallock, The SimBioSys Team, Daniel Cook
Publikováno v:
Journal of Clinical Oncology. 40:e12541-e12541
e12541 Background: Race-related differences in breast cancer incidence and clinical outcome have been well documented, with many studies focusing on socioeconomic determinants contributing to African American (AA) breast cancer patients having higher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af631f8432e2500d60fc018bed93d2b0
https://doi.org/10.1200/jco.2022.40.16_suppl.e12541
https://doi.org/10.1200/jco.2022.40.16_suppl.e12541
Autor:
Zane R. Thornburg, David Bianchi, Troy A. Brier, Benjamin R. Gilbert, Tyler M. Earnest, Marcelo Cardoso dos Reis Melo, Andras Cook, Kim S. Wise, Hamilton O. Smith, Clyde A. Hutchison, John I. Glass, Zaida Luthey-Schulten
Publikováno v:
Biophysical Journal. 121:125a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58876e1d2ac302f96d99f46d64c6e4de
https://doi.org/10.1016/j.bpj.2021.11.2107
https://doi.org/10.1016/j.bpj.2021.11.2107
Autor:
Zane R. Thornburg, David M. Bianchi, Troy A. Brier, Benjamin R. Gilbert, Tyler M. Earnest, Marcelo C.R. Melo, Nataliya Safronova, James P. Sáenz, András T. Cook, Kim S. Wise, Clyde A. Hutchison, Hamilton O. Smith, John I. Glass, Zaida Luthey-Schulten
Publikováno v:
Cell. 185:345-360.e28
We present a whole-cell fully dynamical kinetic model (WCM) of JCVI-syn3A, a minimal cell with a reduced genome of 493 genes that has retained few regulatory proteins or small RNAs. Cryo-electron tomograms provide the cell geometry and ribosome distr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f563ec4b399fd4b4fa4d574a7e619e3
https://doi.org/10.1016/j.cell.2021.12.025
https://doi.org/10.1016/j.cell.2021.12.025