Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tyler L. Harris"'
Autor:
William T. Barker, Tyler L. Harris, Courtney E. Chandler, Christian Melander, Sara E. Martin, T. Vu Nguyen, Robert K. Ernst, Yohei Doi, Roberta J. Melander, Christopher Goodell
Publikováno v:
Bioorganicmedicinal chemistry. 25(20)
Bacterial resistance to polymyxin antibiotics has taken on a new and more menacing form. Common are genomically-encoded resistance mechanisms to polymyxins, specifically colistin (polymyxin E), however, the plasmid-borne mobile colistin resistance-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a8540d96b01f64b295c67683f055e3
https://pubmed.ncbi.nlm.nih.gov/28958847
https://pubmed.ncbi.nlm.nih.gov/28958847
Publikováno v:
ACS infectious diseases. 1(5)
The anthelmintic closantel has shown promise in abrogating the L3 molting of Onchocerca volvulus, the causative agent of the infectious disease onchocerciasis. In our search for alternative scaffolds, we utilized a fragment replacement/modification a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82f5e38d33340a93d2b1f5af20b2012
https://pubmed.ncbi.nlm.nih.gov/27622649
https://pubmed.ncbi.nlm.nih.gov/27622649
Autor:
Cody J. Wenthur, Grahame Mackenzie, Kim D. Janda, Tyler L. Harris, Alberto Diego-Taboada, T. S. Corbitt
Publikováno v:
Chem Commun (Camb)
3,4-Diaminopyridine has shown promise in reversing botulinum intoxication, but poor pharmacokinetics and a narrow therapeutic window limit its clinical utility. Thus, we developed a pH-dependent oral delivery platform using club moss spore exines. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3560e8b6bb101981f455e58d5f2c91e7
https://pubmed.ncbi.nlm.nih.gov/26906286
https://pubmed.ncbi.nlm.nih.gov/26906286
Autor:
Kyoji Tsuchikama, Tyler L. Harris, Gunnar F. Kaufmann, Jie Zhu, Major Gooyit, Kim D. Janda, Daniel Globisch
Publikováno v:
Angewandte Chemie (International ed. in English). 55(12)
Reported herein is that (4S)-4,5-dihydroxy-2,3-pentanedione (DPD) can undergo a previously undocumented non-enzymatic glycation reaction. Incubation of DPD with viral DNA or the antibiotic gramicidin S resulted in significant biochemical alterations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4bded966e1797aedb27e1f6e8219a5
https://pubmed.ncbi.nlm.nih.gov/26890076
https://pubmed.ncbi.nlm.nih.gov/26890076
Autor:
Tyler L. Harris, Xiaoqing Cai, Malcolm R. Wood, Major Gooyit, Matthew Lardy, Jie Zhu, Kim D. Janda
Publikováno v:
Chemistrybiology. 22(4)
Summary The emergence of antibiotic resistance places a sense of urgency on the development of alternative antibacterial strategies, of which targeting virulence factors has been regarded as a "second generation" antibiotic approach. In the case of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e724619e6de12383441a5d73181b7f58
https://pubmed.ncbi.nlm.nih.gov/25910240
https://pubmed.ncbi.nlm.nih.gov/25910240
Autor:
David M. Margolis, Noelle P. Dahl, Daniel L. Feldheim, Candice A. Smith, Erick A. Lindsey, Daniel C. Whitehead, Jamee Bresee, Carrie A. Simpson, Christian Melander, Tyler L. Harris, Carolina Garrido, Carly J. Carter
Background: Antiretroviral therapy (ART) has improved lifespan and quality of life of patients infected with the HIV-1. However, ART has several potential limitations, including the development of drug resistance and suboptimal penetration to selecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cdb2970a07be3f461e85ee15df3dd1
Botulinum neurotoxicity is characterized by peripheral neuromuscular blockade/flaccid paralysis that can lead to respiratory failure and ultimately death. Current therapeutic options provide relief in a pre-exposure scenario, but there are no clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a02cb9592dea67f4f32582cdec42cdc
https://europepmc.org/articles/PMC4140587/
https://europepmc.org/articles/PMC4140587/
Autor:
Andrew A. Yeagley, Rui Su, Tyler L. Harris, Christian Melander, Lingling Peng, Robert K. Ernst, Roberta J. Worthington, Robert E. Furlani, Kara McColough, Christopher Bracket, Zhaoming Su
New approaches are required to control multi-drug resistant (MDR) bacterial infections in military medical facilities, as injured Warfighters are highly susceptible to such infections. 2-Aminoimidazole compounds that, at low micromolar levels and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ad78c1f522eb705cadc167a8a8b728
https://doi.org/10.21236/ada599268
https://doi.org/10.21236/ada599268
Autor:
Daniel V. Zurawski, Tyler L. Harris, Lauren E. Hittle, Roberta J. Worthington, Robert K. Ernst, Christian Melander
Publikováno v:
ACS chemical biology. 9(1)
Infections caused by multi-drug resistant bacteria, particularly Gram-negative bacteria, are an ever-increasing problem. While the development of new antibiotics remains one option in the fight against bacteria that have become resistant to currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9c88a91855dd9034d43aeaa9829340
https://pubmed.ncbi.nlm.nih.gov/24131198
https://pubmed.ncbi.nlm.nih.gov/24131198
Publikováno v:
Angewandte Chemie (International ed. in English). 51(45)
The use of adjuvant molecules that have the ability to restore the susceptibility of multi-drug resistant bacteria, such as MRSA, to clinically available antibiotics is a promising alternative to the development of novel antimicrobials. We report an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dec95aafaf7cfbad9dd325797db6b2
https://pubmed.ncbi.nlm.nih.gov/23047322
https://pubmed.ncbi.nlm.nih.gov/23047322