Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Tyler J Peat"'
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Akademický článek
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription
Autor: Navdeep Malik, Hualong Yan, Nellie Moshkovich, Murali Palangat, Howard Yang, Vanesa Sanchez, Zhuo Cai, Tyler J. Peat, Shunlin Jiang, Chengyu Liu, Maxwell Lee, Beverly A. Mock, Stuart H. Yuspa, Daniel Larson, Lalage M. Wakefield, Jing Huang
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
CBFB is highly mutated in breast cancers and is known to interact with RUNX proteins to regulate transcription. Here, the authors describe a non-canonical role of CBFB in translation regulation in which it binds to mRNAs through hnRNPK, facilitating
Externí odkaz: https://doaj.org/article/3c11e12f7be441d2bf872bf286db67bb
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The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription
Autor: Maxwell P. Lee, Shunlin Jiang, Vanesa C. Sanchez, Nellie Moshkovich, Navdeep Malik, Tyler J Peat, Hualong Yan, Beverly A. Mock, Murali Palangat, Chengyu Liu, Jing Huang, Stuart H. Yuspa, Lalage M. Wakefield, Daniel R. Larson, Howard H. Yang, Zhuo Cai
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Translation and transcription are frequently dysregulated in cancer. These two processes are generally regulated by distinct sets of factors. The CBFB gene, which encodes a transcription factor, has recently emerged as a highly mutated driver in a va
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daccda3e6cd3bbbaa3bd9c6addcadd75
https://doaj.org/article/3c11e12f7be441d2bf872bf286db67bb
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7
Fatty acid oxidation is required for embryonic stem cell survival during metabolic stress
Autor: Maxwell P. Lee, King C. Chan, Navdeep Malik, Hualong Yan, Yunlong He, Yu-Chou Tseng, Huaitian Liu, Jing Huang, Mangmang Li, Waseem Alzamzami, Joe T Nguyen, Beverly A. Mock, Wendy Dubois, Tyler J Peat, Thorkell Andresson, Lino Tessarollo, Gamze Ayaz, Young-Im Kim
Publikováno v: EMBO Rep
Metabolic regulation is critical for the maintenance of pluripotency and the survival of embryonic stem cells (ESCs). The transcription factor Tfcp2l1 has emerged as a key factor for the naive pluripotency of ESCs. Here, we report an unexpected role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc4511d612e3b320237d05747599494
https://europepmc.org/articles/PMC8183408/
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8
Mouse tumor susceptibility genes identify drug combinations for multiple myeloma
Autor: Sayeh Gorjifard, Beverly A. Mock, Snehal M. Gaikwad, Shuling Zhang, V Keith Hughitt, Wendy Dubois, Ke Zhang, Tyler J Peat, John K. Simmons
Publikováno v: Journal of cancer metastasis and treatment
Long-term genetic studies utilizing backcross and congenic strain analyses coupled with positional cloning strategies and functional studies identified Cdkn2a, Mtor, and Mndal as mouse plasmacytoma susceptibility/resistance genes. Tumor incidence dat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2ea33fd8bc2955b5a04b1d05269ec7
https://pubmed.ncbi.nlm.nih.gov/32923678
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9
Hypomorphic mTOR downregulates CDK6 and delays thymic Pre-T LBL tumorigenesis
Autor: Wendy Dubois, Benjamin J. Gamache, Beverly A. Mock, Shuling Zhang, Matti Kiupel, Snehal M. Gaikwad, John K. Simmons, Ke Zhang, Aleksandra M. Michalowski, Tuddow Thaiwong, Joy Gary, Nicholas Watson, Tyler J Peat, Jinfei Xu, Joseph R. Testa, Jinqiu-Qiu Chen, Maudeline Etienne, Alexander L. Kovalchuk, R. Mark Simpson
Publikováno v: Mol Cancer Ther
PI3K/AKT/mTOR pathway hyperactivation is frequent in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL). To model inhibition of mTOR, pre–T-cell lymphoblastic leukemia/lymphoma (pre-T LBL) tumor development was monitored in mice with T lympho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f6693ab8d53846e8c0c885c9305b25
https://europepmc.org/articles/PMC9574474/
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10
Fatty Acid Patterns Detected By Ambient Ionization Mass Spectrometry in Canine Invasive Urothelial Carcinoma From Dogs of Different Breeds
Autor: José A. Ramos-Vara, Deborah W. Knapp, Cedric D'Hue, Tyler J Peat, Alan K. Jarmusch, Deepika Dhawan, R. Graham Cooks
Publikováno v: Bladder Cancer (Amsterdam, Netherlands)
Background In early work ambient ionization mass spectrometry (MS) revealed lipid patterns distinguishing muscle invasive bladder cancer (invasive urothelial carcinoma, InvUC) from normal urothelium. A new ambient ionization MS approach, touch spray
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ffaddefcaa175aa193bbe5bb6b55dd
http://europepmc.org/articles/PMC6087441
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