Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization.

Autor: Safia S Aljedani, Tyler J Liban, Karen Tran, Ganesh Phad, Suruchi Singh, Viktoriya Dubrovskaya, Pradeepa Pushparaj, Paola Martinez-Murillo, Justas Rodarte, Alex Mileant, Vidya Mangala Prasad, Rachel Kinzelman, Sijy O'Dell, John R Mascola, Kelly K Lee, Gunilla B Karlsson Hedestam, Richard T Wyatt, Marie Pancera

Publikováno v: PLoS Pathogens, Vol 17, Iss 9, p e1009543 (2021)

Understanding the molecular mechanisms by which antibodies target and neutralize the HIV-1 envelope glycoprotein (Env) is critical in guiding immunogen design and vaccine development aimed at eliciting cross-reactive neutralizing antibodies (NAbs). H

Externí odkaz: https://doaj.org/article/5d1e169cb38444308637152c824457f6

Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family

Autor: Satyaki Sengupta, Edgar M. Medina, Nicolas E. Buchler, Tyler J. Liban, Sarvind Tripathi, R. William Henry, Seth M. Rubin

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 19

The retinoblastoma protein (Rb) and the homologous pocket proteins p107 and p130 negatively regulate cell proliferation by binding and inhibiting members of the E2F transcription factor family. The structural features that distinguish Rb from other p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afbd7ac69c862c72de57cd079fe5e26
https://doi.org/10.1073/pnas.1619170114

Structural mechanisms of DREAM complex assembly and regulation

Autor: Tyler J. Liban, Seth M. Rubin, Jessica Felthousen, Parameshwaran Ramanan, Keelan Z. Guiley, Larisa Litovchick

Publikováno v: Genes & development, vol 29, iss 9
Guiley, KZ; Liban, TJ; Felthousen, JG; Ramanan, P; Litovchick, L; & Rubin, SM. (2015). Structural mechanisms of DREAM complex assembly and regulation. Genes and Development, 29(9), 961-974. doi: 10.1101/gad.257568.114. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/1852x8zx

© 2015 Guiley et al. The DREAM complex represses cell cycle genes during quiescence through scaffolding MuvB proteins with E2F4/5 and the Rb tumor suppressor paralog p107 or p130. Upon cell cycle entry, MuvB dissociates from p107/p130 and recruits B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021f4354051c66b6db76737060d7ade6
https://doi.org/10.1101/gad.257568.114

Multiple mechanisms for E2F binding inhibition by phosphorylation of the retinoblastoma protein C-terminal domain

Autor: Tyler J. Liban, Seth M. Rubin, Jason R. Burke, Hsiau-Wei Lee, Tamara Restrepo

Publikováno v: Journal of molecular biology, vol 426, iss 1
Burke, JR; Liban, TJ; Restrepo, T; Lee, HW; & Rubin, SM. (2014). Multiple mechanisms for E2F binding inhibition by phosphorylation of the retinoblastoma protein C-terminal domain. Journal of Molecular Biology, 426(1), 245-255. doi: 10.1016/j.jmb.2013.09.031. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/8jv5f544

The retinoblastoma protein C-terminal domain (RbC) is necessary for the tumor suppressor protein's activities in growth suppression and E2F transcription factor inhibition. Cyclin-dependent kinase phosphorylation of RbC contributes to Rb inactivation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05ecf7c51940210d1cb938e597eff46
https://escholarship.org/uc/item/8jv5f544