Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tyler J Browne"'
Autor:
Kelly M Smith, Tyler J Browne, Olivia C Davis, A Coyle, Kieran A Boyle, Masahiko Watanabe, Sally A Dickinson, Jacqueline A Iredale, Mark A Gradwell, Phillip Jobling, Robert J Callister, Christopher V Dayas, David I Hughes, Brett A Graham
Publikováno v:
eLife, Vol 8 (2019)
Nociceptive information is relayed through the spinal cord dorsal horn, a critical area in sensory processing. The neuronal circuits in this region that underpin sensory perception must be clarified to better understand how dysfunction can lead to pa
Externí odkaz:
https://doaj.org/article/e0cd9725113d49e9aa0bf5e1f78d7155
Autor:
Tyler J. Browne, Kelly M. Smith, Mark A. Gradwell, Christopher V. Dayas, Robert J. Callister, David I. Hughes, Brett A. Graham
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Spinal projection neurons (PNs) are defined by long axons that travel from their origin in the spinal cord to the brain where they relay sensory information from the body. The existence and function of a substantial axon collateral network,
Externí odkaz:
https://doaj.org/article/ec93f78f34ca4384b30c43e37a0ef70a
Autor:
Olivia C. Davis, Allen C. Dickie, Marami B. Mustapa, Kieran A. Boyle, Tyler J. Browne, Mark A. Gradwell, Kelly M. Smith, Erika Polgár, Andrew M. Bell, Éva Kókai, Masahiko Watanabe, Hendrik Wildner, Hanns Ulrich Zeilhofer, David D. Ginty, Robert J. Callister, Brett A. Graham, Andrew J. Todd, David I. Hughes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Unmyelinated non-peptidergic nociceptors (NP afferents) arborise in lamina II of the spinal cord and receive GABAergic axoaxonic synapses, which mediate presynaptic inhibition. However, until now the source of this axoaxonic synaptic input w
Externí odkaz:
https://doaj.org/article/e1e8b47c69cd415985186a348e491925
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The pain experience depends on the relay of nociceptive signals from the spinal cord dorsal horn to higher brain centers. This function is ultimately achieved by the output of a small population of highly specialized neurons called projection neurons
Externí odkaz:
https://doaj.org/article/5f0fa275e7564d96b0f9b7499d0fea4f
Autor:
Jessica F. Madden, Olivia C. Davis, Kieran A. Boyle, Jacqueline A. Iredale, Tyler J. Browne, Robert J. Callister, Douglas W. Smith, Phillip Jobling, David I. Hughes, Brett A. Graham
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Neurons located in dorsal root ganglia (DRG) are crucial for transmitting peripheral sensations such as proprioception, touch, temperature, and nociception to the spinal cord before propagating these signals to higher brain structures. To date, diffi
Externí odkaz:
https://doaj.org/article/bede2859bc2b436ba560bb1b689f3474
Autor:
Tyler J. Browne, Mark A. Gradwell, Jacqueline A. Iredale, Jessica F. Maden, Robert J. Callister, David I. Hughes, Christopher V. Dayas, Brett A. Graham
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The superficial dorsal horn (SDH, LI-II) of the spinal cord receives and processes multimodal sensory information from skin, muscle, joints, and viscera then relay it to the brain. Neurons within the SDH fall into two broad categories, projection neu
Externí odkaz:
https://doaj.org/article/f7cbb58569d74ea7bf1a6fa6f2d258b2
Autor:
Brett A. Graham, James S. Welsh, Robert J. Callister, Jessica F. Madden, Augustus Elton, Tyler J. Browne, Hannah R. Drury, Jeremy G. Stoddard, Jacqueline A Iredale
Publikováno v:
Journal of visualized experiments : JoVE. (180)
The roles and connectivity of specific types of neurons within the spinal cord dorsal horn (DH) are being delineated at a rapid rate to provide an increasingly detailed view of the circuits underpinning spinal pain processing. However, the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba271482a09e1cb76ec05ecc50baac4
https://pubmed.ncbi.nlm.nih.gov/35225253
https://pubmed.ncbi.nlm.nih.gov/35225253
Autor:
Christopher V. Dayas, Robert J. Callister, Brett A. Graham, Tyler J Browne, Mark A Gradwell, Kelly M. Smith, David Hughes, Jacqueline A Iredale
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. Mouse lamina I spinoparabrachial projection neurons exhibit heterogenous electrophysiological and morphological characteristics that can be used to distinguish 4 discrete subpopulations. Lamina I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a2fde9bc2cf87fef242315a8e9e790
https://eprints.gla.ac.uk/228995/1/228995.pdf
https://eprints.gla.ac.uk/228995/1/228995.pdf
Autor:
Christopher V. Dayas, Kelly M. Smith, Kieran A. Boyle, Mark A Gradwell, Alison M. Bell, David Hughes, F. S. Peralta Reyes, Brendan A. Graham, Robert J. Callister, J. Leonardo, Tyler J Browne, A. C. Dickie
Parvalbumin-expressing interneurons (PVINs) in the spinal dorsal horn are found primarily in laminae II inner and III. Inhibitory PVINs (iPVINs) play an important in segregating innocuous tactile input from pain-processing circuits, achieved through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b2778309046e8b36980ac89ac234515
https://doi.org/10.1101/2020.12.23.424233
https://doi.org/10.1101/2020.12.23.424233
Autor:
Kelly M Smith, Tyler J Browne, Olivia C Davis, A Coyle, Kieran A Boyle, Masahiko Watanabe, Sally A Dickinson, Jacqueline A Iredale, Mark A Gradwell, Phillip Jobling, Robert J Callister, Christopher V Dayas, David I Hughes, Brett A Graham
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07ad12725209ae7b804c041509ab4238
https://doi.org/10.7554/elife.49190.sa2
https://doi.org/10.7554/elife.49190.sa2