Immune evasion in cell-based immunotherapy: unraveling challenges and novel strategies

Autor: Yan-Ruide Li, Tyler Halladay, Lili Yang

Publikováno v: Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-16 (2024)

Abstract Cell-based immunotherapies (CBIs), notably exemplified by chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy, have emerged as groundbreaking approaches for cancer therapy. Nevertheless, akin to various other therapeutic modali

Externí odkaz: https://doaj.org/article/e7d2bcb0838e4ffe80b0ca95d4555e4a

Laparoscopic repair of recurrent inguinal hernia offers similar outcomes and quality of life to primary laparoscopic repair

Autor: Stephen P. Haggerty, John G. Linn, Tyler Hall, Mike Ujiki, Woody Denham, Beau Forester, Kristine Kuchta

Publikováno v: Hernia : the journal of hernias and abdominal wall surgery. 25(1)

Open repair of recurrent inguinal hernias has been shown to result in significantly poorer perioperative outcomes when compared to open primary hernia repair. However, limited data exist comparing primary and recurrent laparoscopic inguinal hernia re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9597acf63be80c554292c3e57770891d
https://pubmed.ncbi.nlm.nih.gov/32447535

Inhibition of uPA-uPAR signaling restores respiratory epithelial barrier function in asthma and COPD

Autor: Tyler Hall, Megan J. Webster, Ingrid Christ, Matthias Hoffmann, Ines Kollak, David J. Lamb, Eva Peter, Victoria Schroeder, Jun Li, Neil Goeghagen, Frank Buettner, M.J. Thomas, Gisela Schnapp, James P. Garnett, Bernd Guilliard, Felix Schiele, Jennifer Schuett

Publikováno v: Mechanisms of lung injury and repair.

In addition to uPA’s well-characterized role in fibrinolysis, recent publications have indicated a role for uPA-uPAR signaling in respiratory epithelia barrier function. Furthermore, uPA and uPAR expression/signaling are enhanced in severe asthmati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53325ab704596a9278e050cdb05ae031
https://doi.org/10.1183/13993003.congress-2019.pa3856

Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension

Autor: Jeffrey Teckman, Philip Rosenthal, Kieran Hawthorne, Cathie Spino, Lee M. Bass, Karen F. Murray, Nanda Kerkar, John C. Magee, Saul Karpen, James E. Heubi, Jean P. Molleston, Robert H. Squires, Binita M. Kamath, Stephen L. Guthery, Kathleen M. Loomes, Averell H. Sherker, Ronald J. Sokol, Estella Alonso, Lee Bass, Susan Kelly, Mary Riordan, Hector Melin-Aldana, Jorge Bezerra, Kevin Bove, James Heubi, Alexander Miethke, Greg Tiao, Julie Denlinger, Erin Chapman, Ronald Sokol, Amy Feldman, Cara Mack, Michael Narkewicz, Frederick Suchy, Shikha Sundaram, Johan Van Hove, Benigno Garcia, Mikaela Kauma, Kendra Kocher, Matthew Steinbeiss, Mark Lovell, Kathleen Loomes, David Piccoli, Elizabeth Rand, Pierre Russo, Nancy Spinner, Jessi Erlichman, Samantha Stalford, Dina Pakstis, Sakya King, Robert Squires, Rakesh Sindhi, Veena Venkat, Kathy Bukauskas, Patrick McKiernan, Lori Haberstroh, James Squires, Laura Bull, Joanna Curry, Camille Langlois, Grace Kim, Jeffery Teckman, Vikki Kociela, Rosemary Nagy, Shraddha Patel, Jacqueline Cerkoski, Molly Bozic, Girish Subbarao, Ann Klipsch, Cindy Sawyers, Oscar Cummings, Simon Horslen, Karen Murray, Evelyn Hsu, Kara Cooper, Melissa Young, Laura Finn, Binita Kamath, Vicky Ng, Claudia Quammie, Juan Putra, Deepika Sharma, Aishwarya Parmar, Stephen Guthery, Kyle Jensen, Ann Rutherford, Amy Lowichik, Linda Book, Rebecka Meyers, Tyler Hall, Kasper Wang, Sonia Michail, Danny Thomas, Catherine Goodhue, Rohit Kohli, Larry Wang, Nisreen Soufi, Daniel Thomas, Nitika Gupta, Rene Romero, Miriam B. Vos, Rita Tory, John-Paul Berauer, Carlos Abramowsky, Jeanette McFall, Benjamin Shneider, Sanjiv Harpavat, Paula Hertel, Daniel Leung, Mary Tessier, Deborah Schady, Laurel Cavallo, Diego Olvera, Christina Banks, Cynthia Tsai, Richard Thompson, Edward Doo, Jay Hoofnagle, Averell Sherker, Rebecca Torrance, Sherry Hall, John Magee, Robert Merion, Wen Ye

Publikováno v: J Pediatr

Objectives To identify predictors of portal hypertension, liver transplantation, and death in North American youth with alpha-1-antitrypsin (AAT) deficiency, and compare with patients with AAT deficiency elsewhere. Study design The Childhood Liver Di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd1fb8e0c5fcfe9176513fd965cc3df
https://doi.org/10.1016/j.jpeds.2020.07.031

Patient-Centered Outcomes after Laparoscopic Paraesophageal Hernia Repair

Autor: Kristine Kuchta, John G. Linn, Raymond J. Joehl, Stephen P. Haggerty, Michael B. Ujiki, Natalie Warnes, Woody Denham, Herbert M. Hedberg, Tyler Hall, Stephanie Novak

Publikováno v: Journal of the American College of Surgeons. 227(1)

The aim of this study is to investigate patient-centered quality of life (QOL) outcomes in patients undergoing laparoscopic paraesophageal hernia repair.We prospectively followed patients who underwent laparoscopic paraesophageal hernia repair betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69d4f405314361772d4e495d23f120f
https://pubmed.ncbi.nlm.nih.gov/29941115