Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tyler Grebe"'
Autor:
James S. Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J. Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R. J. Davey, David I. Fisher, Eric T. Gangl, Tyler Grebe, Ryan D. Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J. Hughes, Thomas A. Hunt, Tony Johnson, Stefan L. Kavanagh, Teresa C. M. Klinowska, Carrie J. B. Larner, Mandy Lawson, Andrew S. Lister, David Longmire, Stacey Marden, Thomas M. McGuire, Caroline McMillan, Lindsay McMurray, Christopher J. Morrow, J. Willem M. Nissink, Thomas A. Moss, Daniel H. O’Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J. Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Publikováno v:
Journal of Medicinal Chemistry. 66:2918-2945
Autor:
Tieguang Yao, Liangwei Wu, Craig S. Donald, Douglas Ferguson, Lei Wang, Andrew Pike, Jianyan Wang, Justin Cidado, Dedong Wu, Kurt Gordon Pike, Kumar Thakur, Chungang Gu, Calum Cook, James Horstick, Tyler Grebe, Theresa Proia, Darren Stead, Alexander Hird, Michelle Lamb, Wenlin Shao, Nichole O'Connell, Yun Jiang, Sudhir M. Hande, Bin Yang, Janet Hawkins, Barlaam Bernard Christophe, Neil Sumner, Melissa Vasbinder, Andrew D. Ferguson, Jane E. Moore, Jeffrey G. Varnes, Bryan Roberts, Maryann San Martin, Lisa Drew, Ujjal Sarkar, Allan Dishington, Chris De Savi, Robert Casella, Steve C. Glossop, Jane L. Holmes, Thomas M. McGuire
Publikováno v:
Journal of Medicinal Chemistry. 63:15564-15590
A CDK9 inhibitor having short target engagement would enable a reduction of Mcl-1 activity, resulting in apoptosis in cancer cells dependent on Mcl-1 for survival. We report the optimization of a series of amidopyridines (from compound 2), focusing o
Autor:
Haixia Wang, Lakshmaiah Gingipalli, Bo Peng, Xiaolan Zheng, Jeffrey Boerth, Ye Wu, Sharon Tentarelli, Ariamala Gopalsamy, Scott D. Edmondson, Li Sha, Tyler Grebe, David Emmons, Holia Hatoum-Mokdad
Publikováno v:
Organic Letters. 22:3418-3422
In this report, we describe a new photoredox catalyzed 1,4-conjugate addition of N-substituted acetic acids to electron-deficient olefins via decarboxylative C–C bond formation. This C–C bond forma...
Autor:
Haixia Wang, Stefan Kavanagh, Radoslaw Polanski, Eric Gangl, Michael J. Tucker, Jason Breed, Thomas Anthony Hunt, Paul R. J. Davey, Mandy Lawson, Darren Stead, Oona Delpuech, Ye Wu, J. Willem M. Nissink, Barlaam Bernard Christophe, Dedong Wu, Sudhir M. Hande, Amber Balazs, Dermot F. McGinnity, Wenzhan Yang, Thomas A. Moss, Bin Yang, Sladjana Gagrica, Kumar Thakur, Stacey Marden, Tyler Grebe, Daniel Hillebrand O'donovan, Teresa Klinowska, Samantha Jayne Hughes, Kara Herlihy, David I Fisher, Stephen Stokes, Holia Hatoum-Mokdad, Tony Johnson, James S. Scott, Elisabetta Chiarparin, Bo Peng, Sophie L. M. Janbon, Scott Throner, Ryan Greenwood, David Matthew Wilson, Andrew Lister, Stephen Fawell, Hoan Huynh, Jeffrey G. Varnes, Christopher J. Morrow, Rodrigo J. Carbajo
Publikováno v:
Journal of medicinal chemistry. 63(23)
Herein we report the optimization of a series of tricyclic indazoles as selective estrogen receptor degraders (SERD) and antagonists for the treatment of ER+ breast cancer. Structure based design together with systematic investigation of each region
Autor:
Lakshmaiah, Gingipalli, Jeffrey, Boerth, David, Emmons, Tyler, Grebe, Holia, Hatoum-Mokdad, Bo, Peng, Li, Sha, Sharon, Tentarelli, Haixia, Wang, Ye, Wu, XiaoLan, Zheng, Scott, Edmondson, Ariamala, Gopalsamy
Publikováno v:
Organic letters. 22(9)
In this report, we describe a new photoredox catalyzed 1,4-conjugate addition of
Autor:
Tyler Grebe, Ye Wu, Sudhir M. Hande, Mark Cornebise, Lakshmaiah Gingipalli, Jeffrey G. Varnes, Scott Throner, Edward J. Hennessy, Valerie Hoesch, Hoan Huynh
Publikováno v:
Tetrahedron Letters. 58:1709-1713
The preparation of a range of 1,5-disubstituted tetrazoles has been achieved through palladium-catalyzed Suzuki coupling. Using appropriately substituted 5-p-toluenesulfonyltetrazoles as substrates (obtained by cycloaddition of a substituted azide wi
Autor:
Anil Patel, Rebecca E. Meadows, Kurt Gordon Pike, Jane E. Moore, Turner Paul, Darren Stead, Barlaam Bernard Christophe, Andrew Stark, Jemma Clark, Janet Hawkins, Bin Yang, Bryan Roberts, Craig S. Donald, Gemma Davison, Esther Moore, Chris De Savi, Tyler Grebe, Calum Cook, Melissa Vasbinder, Simon C. C. Lucas, Andrew Lister, Jeffrey G. Varnes, Kumar Thakur, Sudhir M. Hande, Jane L. Holmes, Thomas M. McGuire, Alexander Hird, Allan Dishington
Publikováno v:
Tetrahedron Letters. 57:4718-4722
As part of a medicinal chemistry program, we adapted known synthetic methods for the late-stage diversification of 2,4-substituted 7-azaindoles. The strengths and weaknesses of these strategies are discussed. In the course of this work, three optimiz
Autor:
Phil Walker, Folkert Reck, John Breen, Joseph V. Newman, Charles J. Eyermann, David E. Ehmann, Janelle Comita-Prevoir, Stewart L. Fisher, Patrick Brassil, Mark Cronin, Richard A. Alm, Vincent Galullo, Marshall Morningstar, Barry R. Hayter, Tyler Grebe, Hajnalka E. Davis, Boudewijn Dejonge, Gloria Anne Breault, Bolin Geng
Publikováno v:
Journal of Medicinal Chemistry. 54:7834-7847
Novel non-fluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) are of interest for the development of new antibacterial agents that are not impacted by target-mediated cross-resistance with fluoroquinolones
Autor:
Kim Martea, Gunther Kern, Harish Shankaran, Michael R. Hale, John G. Swales, Tyler Grebe, Anshul Gupta, Natalie Keirstead, Richard J. A. Goodwin, Jennifer C. Sasaki, Nakpangi Johnson, Aixiang Xue
Publikováno v:
The FASEB Journal. 29
Autor:
Ed T. Buurman, Stephania Livchak, Laurel Hajec, Sushmita D. Lahiri, Robert Albert, Moriah M. Gagnon, Beth Andrews, David C. McKinney, Pamela Hill, Hongming Wang, Ayome Abibi, Nelson B. Olivier, Jason Thresher, Ning Gao, Jian Huang, Tyler Grebe
Publikováno v:
Journal of medicinal chemistry. 56(18)
The tRNA-(N(1)G37) methyltransferase (TrmD) is essential for growth and highly conserved in both Gram-positive and Gram-negative bacterial pathogens. Additionally, TrmD is very distinct from its human orthologue TRM5 and thus is a suitable target for