Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tyler G, Searles"'
Autor:
Keisuke Shirai, Tiffany Chen, Mary Jo Turk, Delaney E Ramirez, Christo P C Dragnev, Tyler G Searles, Nathaniel Spicer, J Louise Lines, Aaron R Hawkes, Wilson L Davis, Asmaa Mohamed, Joseph D Phillips, Pamela C Rosato, Yina H Huang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 11 (2024)
Background Overcoming immune suppression is a major barrier to eliciting potent CD8+ T cell responses against cancer. Treatment with anti-CD4 monoclonal antibody is an effective means for eliminating CD4+Foxp3+ regulatory (Treg) cells in preclinical
Externí odkaz:
https://doaj.org/article/8a59c2f71d024d7c9006dc8599fb23b3
Autor:
Joseph D. Phillips, Kayla A. Fay, Alan J. Bergeron, Peisheng Zhang, Daniel W. Mielcarz, Andrew M. Calkins, Tyler G. Searles, Brock C. Christensen, David J. Finley, Mary Jo Turk, Jacqueline Y. Channon
Publikováno v:
Current Oncology, Vol 30, Iss 5, Pp 5116-5134 (2023)
This pilot study sought to evaluate the circulating levels of immune cells, particularly regulatory T-cell (Treg) subsets, before and after lung resection for non-small cell lung cancer. Twenty-five patients consented and had specimens collected. Ini
Externí odkaz:
https://doaj.org/article/f05396bac04e4256942c29f98881dd5c
Autor:
Kristin S. Fitzpatrick, Hanna N. Degefu, Katrina Poljakov, Madeleine G. Bibby, Allison J. Remington, Tyler G. Searles, Matthew D. Gray, Jim Boonyaratanakornkit, Pamela C. Rosato, Justin J. Taylor
Publikováno v:
The Journal of Immunology. 210:1156-1165
The study of antigen-specific lymphocytes has been a key advancement in immunology the past few decades. The development of multimerized probes containing antigens, peptide:MHC complexes, or other ligands was one innovation allowing the direct study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7171751cd59188ae3ec9d3310a41b08
https://doi.org/10.4049/jimmunol.2200934
https://doi.org/10.4049/jimmunol.2200934
Autor:
Nikhil Khatwani, Yanding Zhao, Keisuke Shirai, Jiang Gui, Fred W. Kolling, Chao Cheng, Jennifer L. Vella, Fatima Haidar, Jichang Han, Mary Turk, Tyler G. Searles, Christina V. Angeles
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundMelanoma patients who develop immunotherapy-related adverse events often have durable responses to treatment. We previously identified that long-term melanoma survivors presenting with the autoimmune adverse event, vitiligo, developed long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784611ee5c06f4007ba14258b203843e
https://doaj.org/article/e4112b67fb7843cdaab7d42db03cb003
https://doaj.org/article/e4112b67fb7843cdaab7d42db03cb003
Autor:
Jan L. Fisher, Marc S. Ernstoff, Keisuke Shirai, Fred W. Kolling, Mary Jo Turk, Shaofeng Yan, Christina V. Angeles, Jichang Han, Aleksey K. Molodtsov, Tyler G. Searles, Justin M. Bader, Yanding Zhao, Peisheng Zhang, Chao Cheng, Jiang Gui
Publikováno v:
Nat Cancer
While T-cell responses to cancer immunotherapy have been avidly studied, long-lived memory has been poorly characterized. In a cohort of metastatic melanoma survivors with exceptional responses to immunotherapy, we probed memory CD8+ T-cell responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624193ea07cc7a74e9aa5b4420d8ba82
https://pubmed.ncbi.nlm.nih.gov/35121962
https://pubmed.ncbi.nlm.nih.gov/35121962
Autor:
Shawn C Musial, Tyler G. Searles, Sierra A. Kleist, Hanna N. Degefu, Jordan F. Isaacs, Alexander G. Skorput, Pamela C. Rosato
Publikováno v:
The Journal of Immunology. 208:165.18-165.18
The shifting paradigm regarding immune surveillance of the central nervous system (CNS) has shed light on immune cell networks thought to be absent from healthy brain tissue. Resident memory T cells (TRM) are a unique subset of memory T cells that pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::380c89c0028ff92f5dce6cb33c1b5405
https://doi.org/10.4049/jimmunol.208.supp.165.18
https://doi.org/10.4049/jimmunol.208.supp.165.18
Publikováno v:
Semin Immunol
Long-lived memory CD8(+) T cells play important roles in tumor immunity. Studies over the past two decades have identified four subsets of memory CD8(+) T cells - central, effector, stem-like, and tissue resident memory - that either circulate throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad4fd74a7942d64738e20a2275d37a81
https://pubmed.ncbi.nlm.nih.gov/33272898
https://pubmed.ncbi.nlm.nih.gov/33272898
Autor:
Aleksey K, Molodtsov, Nikhil, Khatwani, Jennifer L, Vella, Kathryn A, Lewis, Yanding, Zhao, Jichang, Han, Delaney E, Sullivan, Tyler G, Searles, Nicholas K, Preiss, Tamer B, Shabaneh, Peisheng, Zhang, Aaron R, Hawkes, Brian T, Malik, Fred W, Kolling, Edward J, Usherwood, Sandra L, Wong, Joseph D, Phillips, Keisuke, Shirai, Christina V, Angeles, Shaofeng, Yan, Tyler J, Curiel, Yina H, Huang, Chao, Cheng, Mary Jo, Turk
Publikováno v:
Immunity
The nature of the anti-tumor immune response changes as primary tumors progress and metastasize. We investigated the role of resident memory (Trm) and circulating memory (Tcirm) cells in anti-tumor responses at metastatic locations using a mouse mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f23078434d1e559a9003e66d7e526f0
https://pubmed.ncbi.nlm.nih.gov/34525340
https://pubmed.ncbi.nlm.nih.gov/34525340
Autor:
Tyler J. Curiel, Fred W. Kolling, Kathryn A. Lewis, Nikhil Khatwani, Edward J. Usherwood, Aaron R. Hawkes, Joseph D. Phillips, Delaney E. Sullivan, Mary Jo Turk, Tamer B. Shabaneh, Nicholas K. Preiss, Christina V. Angeles, Yanding Zhao, Yina H. Huang, Jichang Han, Peisheng Zhang, Chao Cheng, Tyler G. Searles, Shaofeng Yan, Brian T. Malik, Keisuke Shirai, Jennifer L. Vella, Sandra L. Wong, Aleksey K. Molodtsov
Publikováno v:
Immunity. 54:2117-2132.e7
Summary The nature of the anti-tumor immune response changes as primary tumors progress and metastasize. We investigated the role of resident memory (Trm) and circulating memory (Tcirm) cells in anti-tumor responses at metastatic locations using a mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dab8149e78aaf5c9495fa8c7d8a0ab3d
https://doi.org/10.1016/j.immuni.2021.08.019
https://doi.org/10.1016/j.immuni.2021.08.019
Publikováno v:
Seminars in Immunology. 49:101435
Long-lived memory CD8+ T cells play important roles in tumor immunity. Studies over the past two decades have identified four subsets of memory CD8+ T cells - central, effector, stem-like, and tissue resident memory - that either circulate through bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::463b0fe1b375aab6bce3d77de19e0d1b
https://doi.org/10.1016/j.smim.2020.101435
https://doi.org/10.1016/j.smim.2020.101435