Comparative landscape of genetic dependencies in human and chimpanzee stem cells

Autor: Richard She, Tyler Fair, Nathan K. Schaefer, Reuben A. Saunders, Bryan J. Pavlovic, Jonathan S. Weissman, Alex A. Pollen

Publikováno v: bioRxiv

Comparative studies of great apes provide a window into our evolutionary past, but the extent and identity of cellular differences that emerged during hominin evolution remain largely unexplored. We established a comparative loss-of-function approach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d20392ca305cc800d73290696dd5e7e
https://doi.org/10.1101/2023.03.19.533346

Machine learning dissection of human accelerated regions in primate neurodevelopment

Autor: Sean Whalen, Fumitaka Inoue, Hane Ryu, Tyler Fair, Eirene Markenscoff-Papadimitriou, Kathleen Keough, Martin Kircher, Beth Martin, Beatriz Alvarado, Orry Elor, Dianne Laboy Cintron, Alex Williams, Md. Abul Hassan Samee, Sean Thomas, Robert Krencik, Erik M. Ullian, Arnold Kriegstein, John L. Rubenstein, Jay Shendure, Alex A. Pollen, Nadav Ahituv, Katherine S. Pollard

Publikováno v: Neuron. 111:857-873.e8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06814931495780972a4b47a8cb9a90f3
https://doi.org/10.1016/j.neuron.2022.12.026

Comparative landscape of genetic dependencies in human and chimpanzee stem cells.

Autor: She R; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; These authors contributed equally: Richard She, Tyler Fair., Fair T; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; These authors contributed equally: Richard She, Tyler Fair., Schaefer NK; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Saunders RA; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA, USA., Pavlovic BJ; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Weissman JS; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute Technology, Cambridge 02142, MA., Pollen AA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.; Lead contact.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 20. Date of Electronic Publication: 2023 Mar 20.