Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tyler Eck"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 4, p e0011303 (2023)
Lymphatic filariasis is a debilitating illness with an estimated 50 million cases as of 2018. The majority of cases are caused by the parasitic worm W. bancrofti and additional cases by the worms B. malayi and B. timori. Dihydrofolate reductase (DHFR
Externí odkaz:
https://doaj.org/article/8c20d36c91bc4e7eb05fa27a07735415
Autor:
Tamara Kreiss, Tyler Eck, Brittany Hart, Sreedhar Tummalapalli, David Rotella, John Siekierka
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 3 (2022)
Filariasis, caused by a family of parasitic nematodes, affects millions of individuals throughout the tropics and is a major cause of acute and chronic morbidity. Current drugs are largely used in mass drug administration programs aimed at controllin
Externí odkaz:
https://doaj.org/article/ec2cc13f030a4d05819cf90d38002f33
Autor:
Andrew M Tobias, Dea Toska, Keith Lange, Tyler Eck, Rohit Bhat, Cheryl A Janson, David P Rotella, Ueli Gubler, Nina M Goodey
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197173 (2018)
Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR) have been previously shown to kill Brugia malayi nematodes and to inhibit Brugia malayi DHFR
Externí odkaz:
https://doaj.org/article/2c8a0df7e2ef4f8b811d5074508981ba
Autor:
Tyler Eck, Mariana Laureano de Souza, Melvin Delvillar, Kutub Ashraf, Rammohan R. Yadav Bheemanaboina, Ramappa Chakrasali, Tamara Kreiss, John J. Siekierka, David P. Rotella, Purnima Bhanot, Nina M. Goodey
Publikováno v:
Chembiochem
P. falciparum cGMP-dependent protein kinase (PfPKG) is an enticing anti-malarial drug target. Novel chemotypes are needed because existing inhibitors have safety issues that may prevent further development. This work demonstrates isoxazole-based comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cbf8dfbddf28ef59a5017fb94c15ac
https://pubmed.ncbi.nlm.nih.gov/35044710
https://pubmed.ncbi.nlm.nih.gov/35044710
Autor:
Tyler Eck, John Gordon, Wayne E. Childers, Brandon S. Pybus, Dennis J. Colussi, Tamara Kreiss, Alison Roth, Rammohan R. Yadav Bheemanaboina, David P. Rotella, Shams Ul Mahmood, Patricia J. Lee, Purnima Bhanot, Samantha O. Aylor, Mariana Laureano de Souza, Mariana Lozano Gonzalez, John J. Siekierka
Publikováno v:
ACS Med Chem Lett
[Image: see text] The discovery of new targets for the treatment of malaria, in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8fe3378b6bb8e06313fdebf1e4dbd7
https://europepmc.org/articles/PMC8667308/
https://europepmc.org/articles/PMC8667308/
Autor:
Purnima Bhanot, Mariana Lozano Gonzalez, Brandon S. Pybus, John Gordon, Wayne E. Childers, David P. Rotella, Rammohan R. Yadav Bheemanaboina, Alison Roth, Shams Ul Mahmood, Tamara Kreiss, Tyler Eck, Mariana Laureano de Souza, John J. Siekierka, Dennis J. Colussi, Patricia J. Lee, Samantha O. Aylor
The discovery of new targets for treatment of malaria and in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-dependent protein k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77f95d28b1facf94164495dca7105a0f
https://doi.org/10.1101/2021.11.05.467463
https://doi.org/10.1101/2021.11.05.467463
Autor:
Mariana Lozano Gonzalez, Dennis J. Colussi, Tyler Eck, Samantha O. Aylor, Patty J. Lee, Shams Ul Mahmood, Tamara Kreiss, David P. Rotella, Brandon S. Pybus, Purnima Bhanot, Wayne E. Childers, John Gordon, Alison Roth, Rammohan R. Yadav Bheemanaboina, M. L. de Souza, John J. Siekierka
The discovery of new targets for treatment of malaria advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) could clear infection in a murine model. This enthusiasm was temp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c612db0e19258f774179b67ca88c35b6
https://doi.org/10.1101/2021.08.24.457553
https://doi.org/10.1101/2021.08.24.457553
Autor:
Nina M. Goodey, Bheemanoboina Rry, Tyler Eck, John J. Siekierka, Ramappa Chakrasali, Purnima Bhanot, Laureano de Souza M, Tamara Kreiss, David P. Rotella
P. falciparum cGMP-dependent protein kinase (PfPKG) is an enticing anti-malarial drug target. Structurally novel isoxazole-based compounds were shown to be ATP competitive inhibitors of PfPKG. Isoxazoles 3 and 5 had Ki values of 0.7 ± 0.2 and 2.3 ±
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::354171d010b685e50cfad3da790134e4
https://doi.org/10.1101/2021.06.24.449800
https://doi.org/10.1101/2021.06.24.449800
Autor:
Rammohan R. Yadav Bheemanaboina, Huimin Cheng, Agnieska Chojnowski, Tyler Eck, David P. Rotella, Ramappa Chakrasali, Sreedhar R. Tummalapalli, John J. Siekierka, Tamara Kreiss, Shams Ul Mahmood
Publikováno v:
RSC Med Chem
The cGMP-dependent protein kinase in Plasmodium falciparum (PfPKG) plays multiple roles in the life cycle of the parasite. As a result, this enzyme is a potential target for new antimalarial agents. Existing inhbitors, while potent and active in mala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58966d8faee67aec495b00520a3d78da
https://europepmc.org/articles/PMC7536641/
https://europepmc.org/articles/PMC7536641/
Autor:
Ueli Gubler, Uththara Liyanagunawardana, Thomas Candela, Nina M. Goodey, Jaclyn Catalano, Natalia E. Reis, Michael Little, Katherine Leon H, Tyler Eck, Seema Patel, Cheryl A. Janson
Publikováno v:
Archives of Biochemistry and Biophysics. 692:108545
Many antibacterial and antiparasitic drugs work by competitively inhibiting dihydrofolate reductase (DHFR), a vital enzyme in folate metabolism. The interactions between inhibitors and DHFR active site residues are known in many homologs but the cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61db613d9fcc1c9615dcc2be853fab33
https://doi.org/10.1016/j.abb.2020.108545
https://doi.org/10.1016/j.abb.2020.108545