Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tyler D. Hitchman"'
Autor:
Amanda R. Moore, Leili Ran, Youxin Guan, Jessica J. Sher, Tyler D. Hitchman, Jenny Q. Zhang, Catalina Hwang, Edward G. Walzak, Alexander N. Shoushtari, Sébastien Monette, Rajmohan Murali, Thomas Wiesner, Klaus G. Griewank, Ping Chi, Yu Chen
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2455-2468 (2018)
Summary: Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We gene
Externí odkaz:
https://doaj.org/article/f955f766b62846e19190082e6000d91d
Autor:
Yu Chen, Ping Chi, Thomas Huber, Thomas P. Sakmar, Barry S. Taylor, Matthew T. Chang, Juliet Chen, Youxin Guan, Jasmine H. Francis, Alexander N. Shoushtari, Mohini R. Pachai, Naitao Wang, Ruobing Jia, Cindy Lee, Amanda R. Moore, Emilie Ceraudo, Gabriella Bayshtok, Tyler D. Hitchman
Purpose:All uveal melanoma and a fraction of other melanoma subtypes are driven by activation of the G-protein alpha-q (Gαq) pathway. Targeting these melanomas has proven difficult despite advances in the molecular understanding of key driver signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5081a528234de947ebc82cb311f8ab41
https://doi.org/10.1158/1078-0432.c.6530301
https://doi.org/10.1158/1078-0432.c.6530301
Autor:
Yu Chen, Ping Chi, Thomas Huber, Thomas P. Sakmar, Barry S. Taylor, Matthew T. Chang, Juliet Chen, Youxin Guan, Jasmine H. Francis, Alexander N. Shoushtari, Mohini R. Pachai, Naitao Wang, Ruobing Jia, Cindy Lee, Amanda R. Moore, Emilie Ceraudo, Gabriella Bayshtok, Tyler D. Hitchman
Supplementary figures S1-S6 with figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce8efd4e6384fb453406751fddbe584
https://doi.org/10.1158/1078-0432.22479795.v1
https://doi.org/10.1158/1078-0432.22479795.v1
Autor:
Yu Chen, Ping Chi, Thomas Huber, Thomas P. Sakmar, Barry S. Taylor, Matthew T. Chang, Juliet Chen, Youxin Guan, Jasmine H. Francis, Alexander N. Shoushtari, Mohini R. Pachai, Naitao Wang, Ruobing Jia, Cindy Lee, Amanda R. Moore, Emilie Ceraudo, Gabriella Bayshtok, Tyler D. Hitchman
raw uncropped labeled western blots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3664900e14a101e3af47e3c9420a7341
https://doi.org/10.1158/1078-0432.22479798
https://doi.org/10.1158/1078-0432.22479798
Autor:
Gabriella Bayshtok, Matthew T. Chang, Amanda R. Moore, Tyler D. Hitchman, Emilie Ceraudo, Youxin Guan, Cindy Lee, Thomas P. Sakmar, Ruobing Jia, Alexander N. Shoushtari, Jasmine H. Francis, Ping Chi, Mohini R. Pachai, Juliet Chen, Thomas Huber, Barry S. Taylor, Naitao Wang, Yu Chen
Publikováno v:
Clinical Cancer Research. 27:1476-1490
Purpose: All uveal melanoma and a fraction of other melanoma subtypes are driven by activation of the G-protein alpha-q (Gαq) pathway. Targeting these melanomas has proven difficult despite advances in the molecular understanding of key driver signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47948887edc1ae4f404214233bfd697f
https://doi.org/10.1158/1078-0432.ccr-20-2860
https://doi.org/10.1158/1078-0432.ccr-20-2860
Autor:
Sydney X. Lu, Yu Chen, Daichi Inoue, Justin Taylor, Ariele Block, Robert K. Bradley, Cigall Kadoch, Alex Penson, Andrew R. D’Avino, Khrystyna North, Bo Liu, Brittany C. Michel, Hana Cho, Tyler D. Hitchman, Guo-Liang Chew, Stanley Chun-Wei Lee, Akihide Yoshimi, Joseph Pangallo, Luisa F. Escobar-Hoyos, Omar Abdel-Wahab, Lillian Bitner, Amanda R. Moore
Publikováno v:
Nature
SF3B1 is the most commonly mutated RNA splicing factor in cancer1–4, but the mechanisms by which SF3B1 mutations promote malignancy are poorly understood. Here we integrated pan-cancer splicing analyses with a positive-enrichment CRISPR screen to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bde0c889ae3314a95089ebca3406ace
http://europepmc.org/articles/PMC6858563
http://europepmc.org/articles/PMC6858563
Autor:
Tyler D, Hitchman, Gabriella, Bayshtok, Emilie, Ceraudo, Amanda R, Moore, Cindy, Lee, Ruobing, Jia, Naitao, Wang, Mohini R, Pachai, Alexander N, Shoushtari, Jasmine H, Francis, Youxin, Guan, Juliet, Chen, Matthew T, Chang, Barry S, Taylor, Thomas P, Sakmar, Thomas, Huber, Ping, Chi, Yu, Chen
Publikováno v:
Clin Cancer Res
Most uveal melanomas harbor mutations in Gαq and show constitutive MAPK activation. Although MEK inhibition has some efficacy against uveal melanoma, clinical responses are typically poor. The Gαq inhibitor-MEK inhibitor combination showed prolonge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e16455d44d09e19f6e5698ab8f4d9212
https://pubmed.ncbi.nlm.nih.gov/33355300
https://pubmed.ncbi.nlm.nih.gov/33355300
Autor:
Lu Wang, Jorge S. Reis-Filho, Jiang Wang, Marc Ladanyi, Luciano G. Martelotto, Lee Spraggon, Tyler D. Hitchman, Pang-Dian Fan, Julija Hmeljak, Emily K. Slotkin
Publikováno v:
The Journal of Pathology. 242:102-112
Chromosomal rearrangements encoding oncogenic fusion proteins are found in a wide variety of malignancies. The use of programmable nucleases to generate specific double-strand breaks in endogenous loci, followed by non-homologous end joining DNA repa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9fd238ee22d45c1cc432c192558ca47
https://doi.org/10.1002/path.4883
https://doi.org/10.1002/path.4883
Autor:
Mattheisen Jm, Yu Chen, Mizuho Horioka, Emilie Ceraudo, Ping Chi, Manija A. Kazmi, Amanda R. Moore, Tyler D. Hitchman, Thomas P. Sakmar, Thomas Huber
The G protein-coupled receptor (GPCR) cysteinyl-leukotriene receptor 2 (CysLTR2) with a single amino acid mutation at position 3.43 (Leu replaced with Gln at position 129 in transmembrane helix 3) causes uveal melanoma in humans. The ability of CysLT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43739f2a5cc9ad4611ccde0e83766d9
Autor:
Jordan M. Mattheisen, Amanda R. Moore, Yu Chen, Ping Chi, Manija A. Kazmi, Tyler D. Hitchman, Mizuho Horioka, Thomas P. Sakmar, Emilie Ceraudo, Thomas Huber
Publikováno v:
The Journal of Biological Chemistry
Uveal melanoma is the most common eye cancer in adults and is clinically and genetically distinct from skin cutaneous melanoma. In a subset of cases, the oncogenic driver is an activating mutation in CYSLTR2, the gene encoding the G protein–coupled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5ec74a731e85fd58a86e6fd59224fd
https://doi.org/10.1074/jbc.ra120.015352
https://doi.org/10.1074/jbc.ra120.015352