Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Tyler D. Ames"'
Autor:
Daniel D. Karp, D. Ross Camidge, Jeffery R. Infante, Tyler D. Ames, Matthew R. Price, José Jimeno, Alan H. Bryce
Publikováno v:
EClinicalMedicine, Vol 49, Iss , Pp 101430- (2022)
Summary: Background: PT-112, the first pyrophosphate-platinum conjugate, causes immunogenic cell death in experimental models, leading to recruitment of tumour-infiltrating lymphocytes. PT-112 also associates with bone (osteotropism), likely driven b
Externí odkaz:
https://doaj.org/article/ac87d13436ea457596df59d56074eb82
Autor:
Ruth Soler-Agesta, Joaquín Marco-Brualla, Martha Minjárez-Sáenz, Christina Y. Yim, Marta Martínez-Júlvez, Matthew R. Price, Raquel Moreno-Loshuertos, Tyler D. Ames, José Jimeno, Alberto Anel
Publikováno v:
Cancers, Vol 14, Iss 16, p 3851 (2022)
PT-112 is a novel pyrophosphate–platinum conjugate, with clinical activity reported in advanced pretreated solid tumors. While PT-112 has been shown to induce robust immunogenic cell death (ICD) in vivo but only minimally bind DNA, the molecular me
Externí odkaz:
https://doaj.org/article/6fe94328cdd24ef991d33544dcf78e5c
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
PT-112 is a novel platinum-pyrophosphate conjugate under clinical development for cancer therapy. PT-112 mediates cytostatic and cytotoxic effects against a variety of human and mouse cancer cell lines in vitro. The cytotoxic response to PT-112 is as
Externí odkaz:
https://doaj.org/article/97040e07966a4239b9d813936bf41c3b
Autor:
Tiffany L. Wang BS, Tyler D. Ames BS, Khoi M. Le BS, Corinne Wee BA, Laura S. Phieffer MD, Carmen E. Quatman MD, PhD
Publikováno v:
Geriatric Orthopaedic Surgery & Rehabilitation, Vol 6 (2015)
Objective: The objective of this study was to determine whether advanced practice providers could learn to collect objective functional assessment data accurately and efficiently with commercially available devices that measure kinematics and kinetic
Externí odkaz:
https://doaj.org/article/f9e7946b8b014772979931ada778f18b
Publikováno v:
Orthopedics. 45:373-377
The goal of this study was to compare outcomes among children treated nonoperatively vs operatively for completely displaced clavicle fractures. This was a retrospective cohort study of nonoperative vs operative treatment of completely displaced clav
Autor:
Ruth Soler-Agesta, Tyler D. Ames, Matthew Price, José Jimeno, Christina Y. Yim, Raquel Moreno-Loshuertos, Alberto Anel
Publikováno v:
Cancer Research. 82:1115-1115
Purpose: To investigate PT-112 in a human prostate cancer (PC) cell panel and assess differential sensitivity, cell death mechanism, induction of mitochondrial stress, and release of damage-associated molecular patterns (DAMPs). Background: PT-112 is
Autor:
Matthew Price, Christina Yeaeun Yim, P. Leif Bergsagel, Tyler D Ames, Taxiarchis Kourelis, Dennis L. Cooper, Jose Jimeno, Sikander Ailawadhi, Dan T. Vogl
Publikováno v:
Blood. 136:9-10
Background: PT-112 is a novel pyrophosphate-platinum conjugate with a multi-modal mechanism of action that induces immunogenic cell death and is not susceptible to DNA-repair drug resistance pathways. In phase I studies in solid tumors, PT-112 demons
Autor:
Matthew Price, Roxana S. Dronca, Daniel D. Karp, José Enrique Garzón Jimeno, Brian A. Costello, Tyler D Ames, Ana Aparicio, Sumit K. Subudhi, Alan H. Bryce, Christina Yeaeun Yim, Joseph F. O'Donnell
Publikováno v:
Journal of Clinical Oncology. 39:e17025-e17025
e17025 Background: PT-112 is a novel pyrophosphate-platinum conjugate that induces immunogenic cell death, reaches highest concentrations in bone (osteotropism), and synergizes with immune checkpoint inhibitors (ICIs) in preclinical models. Phase I s
Autor:
Ronald R. Breaker, Adam Roth, Tyler D. Ames, Madeline E. Sherlock, James W. Nelson, Zasha Weinberg, Keith A. Corbino, Kevin R. Perkins, Christina E. Lünse
Publikováno v:
Nucleic Acids Research
The discovery of structured non-coding RNAs (ncRNAs) in bacteria can reveal new facets of biology and biochemistry. Comparative genomics analyses executed by powerful computer algorithms have successfully been used to uncover many novel bacterial ncR
Autor:
Brian A. Costello, Alan H. Bryce, Jeffrey R. Infante, Daniel D. Karp, Tyler D Ames, Jose Jimeno, Roxana S. Dronca
Publikováno v:
Journal of Clinical Oncology. 38:83-83
83 Background: PT-112, the first pyrophosphate conjugate in Phase I/II clinical development, induces robust immunogenic cell death and is osteotropic, prompting study in mCRPC during Phase I. We report safety and efficacy findings in the mCRPC sub-po