Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tyler D P Brunet"'
Autor:
W Ford Doolittle, Tyler D P Brunet
Publikováno v:
PLoS Genetics, Vol 12, Iss 4, p e1005912 (2016)
A universal Tree of Life (TOL) has long been a goal of molecular phylogeneticists, but reticulation at the level of genes and possibly at the levels of cells and species renders any simple interpretation of such a TOL, especially as applied to prokar
Externí odkaz:
https://doaj.org/article/a52dcb757fc047f489b27042e9e8fcfd
Autor:
W. Ford Doolittle, Tyler D. P. Brunet
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-9 (2017)
Abstract The idea that much of our genome is irrelevant to fitness—is not the product of positive natural selection at the organismal level—remains viable. Claims to the contrary, and specifically that the notion of “junk DNA” should be aband
Externí odkaz:
https://doaj.org/article/e3bf49931ae3473bb9613d5653c27528
Publikováno v:
Philosophy & Technology
We argue that artificial networks are explainable and offer a novel theory of interpretability. Two sets of conceptual questions are prominent in theoretical engagements with artificial neural networks, especially in the context of medical artificial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c336b5d5b51a3680f8cc029f5bfc1515
https://doi.org/10.1007/s13347-020-00435-2
https://doi.org/10.1007/s13347-020-00435-2
Autor:
M.D.S. Lekgoathi, Rachel Yoho, Khor Waiho, Ken Dutton-Regester, Kartik Nemani, JiaJia Fu, Ahmed Al Harraq, Tyler D. P. Brunet, Isabel Marín Beltrán, Anna Uzonyi, Akash Mukherjee, Sudhakar Srivastava, Michael J. Strong, Joel Henrique Ellwanger, Yifan Li, Michael A. Tarselli
Publikováno v:
Science. 369:26-29
The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO antigens are also polymorphic in many other primates, with the same two amino acid changes re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2fd47986656ff42e5cb9ea68b0931f
https://doi.org/10.1126/science.abd1320
https://doi.org/10.1126/science.abd1320
Publikováno v:
Studies in history and philosophy of science. 87
Fitness contribution alone should not be the criterion of ‘function’ in molecular biology and genomics. Disagreement over the use of ‘function’ in molecular biology and genomics is still with us, almost eight years after publicity surrounding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2376419706255c746e511463e628eebf
https://pubmed.ncbi.nlm.nih.gov/34111815
https://pubmed.ncbi.nlm.nih.gov/34111815
Autor:
Karl Leuschen, Morgan G. I. Langille, W. Ford Doolittle, S. Andrew Inkpen, Tyler D. P. Brunet, Gavin M. Douglas
Publikováno v:
Biology & Philosophy. 32:1225-1243
Microbiologists are transitioning from the study and characterization of individual strains or species to the profiling of whole microbiomes and microbial ecology. Equipped with high-throughput methods for studying the taxonomic and functional charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6588ad40b6826c33766facc849e2983
https://doi.org/10.1007/s10539-017-9602-2
https://doi.org/10.1007/s10539-017-9602-2
Autor:
Tyler D. P. Brunet
Publikováno v:
Journal of Biotechnology. 226:56-64
Applications of biotechnology to information security are now possible and have potentially far reaching political and technological implications. This change in information security practices, initiated by advancements in molecular biological and bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44210e096618f00e2e80e7643cd62d3
https://doi.org/10.1016/j.jbiotec.2016.03.044
https://doi.org/10.1016/j.jbiotec.2016.03.044
Autor:
Tyler D. P. Brunet, W. Ford Doolittle
Publikováno v:
Biology & Philosophy. 33
Constructive Neutral Evolution (CNE) is an evolutionary mechanism that can explain much molecular inter-dependence and organismal complexity without assuming positive selection favoring such dependency or complexity, either directly or as a byproduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b7bc8c4d49b5528d71c18ce49ff7e79
https://doi.org/10.1007/s10539-018-9614-6
https://doi.org/10.1007/s10539-018-9614-6
Autor:
Tyler D. P. Brunet, W. Ford Doolittle
Publikováno v:
BMC Biology
BMC Biology, Vol 15, Iss 1, Pp 1-9 (2017)
BMC Biology, Vol 15, Iss 1, Pp 1-9 (2017)
The idea that much of our genome is irrelevant to fitness—is not the product of positive natural selection at the organismal level—remains viable. Claims to the contrary, and specifically that the notion of “junk DNA” should be abandoned, are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfd6345109d27b5aaef3a9069faef47
https://doi.org/10.1186/s12915-017-0460-9
https://doi.org/10.1186/s12915-017-0460-9
Autor:
W. Ford Doolittle, Tyler D. P. Brunet
Publikováno v:
Genome Biology and Evolution. 7:2445-2457
One of several issues at play in the renewed debate over "junk DNA" is the organizational level at which genomic features might be seen as selected, and thus to exhibit function, as etiologically defined. The intuition frequently expressed by molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::767fd496ed8fc982754fbf5816c5d4b1
https://doi.org/10.1093/gbe/evv152
https://doi.org/10.1093/gbe/evv152