Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tyler C. Shimko"'
Autor:
Kara Brower, Robert R. Puccinelli, Craig J. Markin, Tyler C. Shimko, Scott A. Longwell, Bianca Cruz, Rafael Gomez-Sjoberg, Polly M. Fordyce
Publikováno v:
HardwareX, Vol 3, Iss , Pp 117-134 (2018)
Microfluidic technologies have been used across diverse disciplines (e.g. high-throughput biological measurement, fluid physics, laboratory fluid manipulation) but widespread adoption has been limited in part due to the lack of openly disseminated re
Externí odkaz:
https://doaj.org/article/c2ebeef00ba34878b2ec942257f44782
Autor:
Polly M. Fordyce, Allison M. Keys, Yaron Orenstein, Daniel D. Le, Tyler C. Shimko, Scott A. Longwell, Arjun K. Aditham
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Transcription factors (TFs) are key proteins that bind DNA targets to coordinate gene expression in cells. Understanding how TFs recognize their DNA targets is essential for predicting how variations in regulatory sequence disrupt transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c1063ba25d2dd41ddbd966dc89b67a
http://europepmc.org/articles/PMC5910820
http://europepmc.org/articles/PMC5910820
Publikováno v:
Bioinformatics
MotivationTranscription factors bind regulatory DNA sequences in a combinatorial manner to modulate gene expression. Deep neural networks (DNNs) can learn the cis-regulatory grammars encoded in regulatory DNA sequences associated with transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0c8c7af2b3cfa42483b6dfbc6aa4ec
Publikováno v:
Methods Cell Biol
Biophysical models of transcriptional regulation rely on energetic measurements of the binding affinities between transcription factors (TFs) and target DNA binding sites. Historically, assays capable of measuring TF-DNA binding affinities have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66d7e25ee0e99d91f3d0420be4c9429
https://doi.org/10.1016/bs.mcb.2018.09.011
https://doi.org/10.1016/bs.mcb.2018.09.011
Autor:
Arjun K. Aditham, Polly M. Fordyce, Allison M. Keys, Yaron Orenstein, Tyler C. Shimko, Daniel D. Le
Transcription factors (TFs) are primary regulators of gene expression in cells, where they bind specific genomic target sites to control transcription. Quantitative measurements of TF-DNA binding energies can improve the accuracy of predictions of TF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9e12e47fde5ab986e12cd84114d1d2
Autor:
Bianca Cruz, Robert Puccinelli, Craig J. Markin, Scott A. Longwell, Polly M. Fordyce, Rafael Gomez-Sjoberg, Tyler C. Shimko, Kara Brower
Publikováno v:
HardwareX, Vol 3, Iss, Pp 117-134 (2018)
Microfluidic technologies have been used across diverse disciplines (e.g. high-throughput biological measurement, fluid physics, laboratory fluid manipulation) but widespread adoption has been limited due to the lack of openly disseminated resources
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603ef8f250b4a8ce18ca8be505466ca3
Autor:
Tyler C. Shimko, Polly M. Fordyce
Publikováno v:
Biophysical Journal. 116:503a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e381ac3e3f7cf5029de9044298f442d
https://doi.org/10.1016/j.bpj.2018.11.2714
https://doi.org/10.1016/j.bpj.2018.11.2714
Autor:
Leonid Kruglyak, Hannah S. Seidel, Erik C. Andersen, Justin P. Gerke, Joshua S. Bloom, Tyler C. Shimko, Rajarshi Ghosh, Jonathan R. Crissman
Publikováno v:
G3: Genes|Genomes|Genetics
The genetic variants underlying complex traits are often elusive even in powerful model organisms such as Caenorhabditis elegans with controlled genetic backgrounds and environmental conditions. Two major contributing factors are: (1) the lack of sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6cc980fb95b75f4294625b1ff758f1
https://pubmed.ncbi.nlm.nih.gov/25770127
https://pubmed.ncbi.nlm.nih.gov/25770127
Autor:
Tyler C Shimko, Erik C Andersen
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111090 (2014)
The R package COPASutils provides a logical workflow for the reading, processing, and visualization of data obtained from the Union Biometrica Complex Object Parametric Analyzer and Sorter (COPAS) or the BioSorter large-particle flow cytometers. Data
Externí odkaz:
https://doaj.org/article/1e32416f356a4de8a19e5c7661fea0a3