Výsledky vyhledávání - "Tyler C. Broussard"

Structural Analysis of Substrate, Reaction Intermediate, and Product Binding in Haemophilus influenzae Biotin Carboxylase

Autor: Ross Bonnot, Svetlana Pakhomova, Grover L. Waldrop, David B. Neau, Tyler C. Broussard

Publikováno v: Biochemistry. 54:3860-3870

Acetyl-CoA carboxylase catalyzes the first and regulated step in fatty acid synthesis. In most Gram-negative and Gram-positive bacteria, the enzyme is composed of three proteins: biotin carboxylase, a biotin carboxyl carrier protein (BCCP), and carbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105b4b7c765b549ceff2aef84d854b0a
https://doi.org/10.1021/acs.biochem.5b00340

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A thioesterase bypasses the requirement for exogenous fatty acids in theplsXdeletion ofStreptococcus pneumoniae

Autor: Tyler C. Broussard, Joost Schalkwijk, Charles O. Rock, Joshua B. Parsons, Matthew W. Frank, Marien I. de Jonge, Marc J. Eleveld

Publikováno v: Molecular Microbiology. 96:28-41

PlsX is an acyl-acyl carrier protein (ACP):phosphate transacylase that interconverts the two acyl donors in Gram-positive bacterial phospholipid synthesis. The deletion of plsX in Staphylococcus aureus results in a requirement for both exogenous fatt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7116af9e2c3ba2e2f9148984a8f5185b
https://doi.org/10.1111/mmi.12916

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The Three-Dimensional Structure of the Biotin Carboxylase-Biotin Carboxyl Carrier Protein Complex of E. coli Acetyl-CoA Carboxylase

Autor: Matthew J. Kobe, Amanda E. Price, Grover L. Waldrop, Svetlana Pakhomova, Tyler S. Champion, David B. Neau, Tyler C. Broussard

Publikováno v: Structure. 21:650-657

SummaryAcetyl-coenzyme A (acetyl-CoA) carboxylase is a biotin-dependent, multifunctional enzyme that catalyzes the regulated step in fatty acid synthesis. The Escherichia coli enzyme is composed of a homodimeric biotin carboxylase (BC), biotinylated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea3d1cbf9c006865a9529e88544887d
https://doi.org/10.1016/j.str.2013.02.001

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Biochemical Roles for Conserved Residues in the Bacterial Fatty Acid-binding Protein Family

Autor: Pamela Jackson, Tyler C. Broussard, Charles O. Rock, Darcie J. Miller, Stephen W. White, Amanda Nourse

Publikováno v: The Journal of biological chemistry. 291(12)

Fatty acid kinase (Fak) is a ubiquitous Gram-positive bacterial enzyme consisting of an ATP-binding protein (FakA) that phosphorylates the fatty acid bound to FakB. In Staphylococcus aureus, Fak is a global regulator of virulence factor transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890899d7f6a7addf9e03d61437278f74
https://pubmed.ncbi.nlm.nih.gov/26774272

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Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus

Autor: Jason W. Rosch, Tyler C. Broussard, Jeffrey L. Bose, Joshua B. Parsons, Chitra Subramanian, Pamela Jackson, Charles O. Rock

Extracellular fatty acid incorporation into the phospholipids of Staphylococcus aureus occurs via fatty acid phosphorylation. We show that fatty acid kinase (Fak) is composed of two dissociable protein subunits encoded by separate genes. FakA provide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dd3dce5a797dd325d90651b955d3ef
https://europepmc.org/articles/PMC4115530/

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Complex formation and regulation of Escherichia coli acetyl-CoA carboxylase

Autor: Grover L. Waldrop, Amanda E. Price, Tyler C. Broussard, Susan M. Laborde

Publikováno v: Biochemistry. 52(19)

Acetyl-CoA carboxylase is a biotin-dependent enzyme that catalyzes the regulated step in fatty acid synthesis. The bacterial form has three separate components: biotin carboxylase, biotin carboxyl carrier protein (BCCP), and carboxyltransferase. Cata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0238691198505d9f3b3658ae6642dc4
https://pubmed.ncbi.nlm.nih.gov/23594205

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