Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tyler C Huff"'
Autor:
Vladimir Camarena, David W Sant, Tyler C Huff, Sushmita Mustafi, Ryan K Muir, Allegra T Aron, Christopher J Chang, Adam R Renslo, Paula V Monje, Gaofeng Wang
Publikováno v:
eLife, Vol 6 (2017)
It is widely accepted that cAMP regulates gene transcription principally by activating the protein kinase A (PKA)-targeted transcription factors. Here, we show that cAMP enhances the generation of 5-hydroxymethylcytosine (5hmC) in multiple cell types
Externí odkaz:
https://doaj.org/article/cb740e3e9cd14769a9739af54a035d72
Autor:
Kevin E. McElhanon, Tyler C. Huff, Dinesh Hirenallur-Shanthappa, Russell A. Miller, Nicolas Christoforou
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, and the incidence of new-onset AF has been increasing over the past two decades. Several factors contribute to the risk of developing AF including age, preexisting cardiovasc
Externí odkaz:
https://doaj.org/article/3ef4bdcfcc87462d98bc7d6ea3e62edc
Autor:
Nadja S. Andrade, Melina Ramic, Rustam Esanov, Wenjun Liu, Mathew J. Rybin, Gabriel Gaidosh, Abbas Abdallah, Samuel Del’Olio, Tyler C. Huff, Nancy T. Chee, Sadhana Anatha, Tania F. Gendron, Claes Wahlestedt, Yanbin Zhang, Michael Benatar, Christian Mueller, Zane Zeier
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-18 (2020)
Abstract Background The C9ORF72 hexanucleotide repeat expansion is the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two fatal age-related neurodegenerative diseases. The C9ORF72 expansion e
Externí odkaz:
https://doaj.org/article/5b25cbfded474c1cbe5d4990bc503838
Autor:
Gaofeng Wang, Claes Wahlestedt, Zhao-Jun Liu, Shaun P. Brothers, David W. Sant, Tyler C. Huff, Claude-Henry Volmar, Vladimir Camarena, Sushmita Mustafi
Bromodomain and extraterminal inhibitors (BETi) are promising cancer therapies, yet prominent side effects of BETi at effective doses have been reported in phase I clinical trials. Here, we screened a panel of small molecules targeting epigenetic mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9634fa39b0de228f65f840915fd0365
https://doi.org/10.1158/0008-5472.c.6509940.v1
https://doi.org/10.1158/0008-5472.c.6509940.v1
Autor:
Gaofeng Wang, Claes Wahlestedt, Zhao-Jun Liu, Shaun P. Brothers, David W. Sant, Tyler C. Huff, Claude-Henry Volmar, Vladimir Camarena, Sushmita Mustafi
This file contains the following supplementary figures, tables and other materials. Figure S1: The expression of BRD2, BRD3 and BRD4 in melanocytes and melanoma cells. Figure S2: Knocking down the expression of BRD4 by siRNA. Figure S3: The effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e62902ef4d35a1b343aea16fc4c21d
https://doi.org/10.1158/0008-5472.22417776
https://doi.org/10.1158/0008-5472.22417776
Publikováno v:
Free Radic Biol Med
Iron is an essential micronutrient metal for cellular functions but can generate highly reactive oxygen species resulting in oxidative damage. For these reasons its uptake and metabolism is highly regulated. A small but dynamic fraction of ferrous ir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0d0f842f5dd6f3360da497aac3ee9a
https://doi.org/10.1016/j.freeradbiomed.2021.01.026
https://doi.org/10.1016/j.freeradbiomed.2021.01.026
Autor:
Sushmita Mustafi, Vladimir Camarena, Rehana Qureshi, Hyunho Yoon, Claude-Henry Volmar, Tyler C. Huff, David W. Sant, Lihong Zheng, Shaun P. Brothers, Claes Wahlestedt, Joyce Slingerland, Gaofeng Wang
Publikováno v:
EBioMedicine, Vol 43, Iss, Pp 201-210 (2019)
Background: Bromodomain and extra-terminal inhibitors (BETi) have shown efficacy for the treatment of aggressive triple negative breast cancer (TNBC). However, BETi are plagued by a narrow therapeutic window as manifested by severe toxicities at effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::f2facf05164cb892732a26b4a91a9dca
http://www.sciencedirect.com/science/article/pii/S2352396419302403
http://www.sciencedirect.com/science/article/pii/S2352396419302403
Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro-myelinating genes
Autor:
Vladimir Camarena, Sushmita Mustafi, Gaofeng Wang, Nadja S. Andrade, Derek J. Van Booven, Tyler C. Huff, Paula V. Monje, David W. Sant
Publikováno v:
J Neurochem
Ascorbic acid (vitamin C) is critical for Schwann cells to myelinate peripheral nerve axons during development and remyelination after injury. However, its exact mechanism remains elusive. Vitamin C is a dietary nutrient that was recently discovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca1ad1cd426d5222720a510ce3e77d9
https://pubmed.ncbi.nlm.nih.gov/32219848
https://pubmed.ncbi.nlm.nih.gov/32219848
Autor:
Christian Mueller, Melina Ramic, Abbas Abdallah, Tania F. Gendron, Zane Zeier, Rustam Esanov, Mathew J. Rybin, Sadhana Anatha, Michael Benatar, Tyler C. Huff, Gabriel Gaidosh, Samuel Del’Olio, Claes Wahlestedt, Nancy T. Chee, Nadja S. Andrade, Wenjun Liu, Yanbin Zhang
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-18 (2020)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background The C9ORF72 hexanucleotide repeat expansion is the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two fatal age-related neurodegenerative diseases. The C9ORF72 expansion encodes fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f354bf00808ba6a343650fae5d17955b
https://doi.org/10.1186/s13024-020-00365-9
https://doi.org/10.1186/s13024-020-00365-9
Autor:
Gaofeng Wang, Tyler C. Huff
Publikováno v:
Vitamin C ISBN: 9780429442025
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90d5ca2dee97a15e4891c102b021b638
https://doi.org/10.1201/9780429442025-12
https://doi.org/10.1201/9780429442025-12