Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Tyler A. Kokjohn"'
Autor:
Chera L. Maarouf, Thomas G. Beach, Charles H. Adler, Michael Malek-Ahmadi, Tyler A. Kokjohn, Brittany N. Dugger, Douglas G. Walker, Holly A. Shill, Sandra A. Jacobson, Marwan N. Sabbagh, Alex E. Roher, Arizona Parkinson’s Disease Consortium
Publikováno v:
Biomarker Insights, Vol 2013, Iss 8, Pp 19-28 (2013)
Externí odkaz:
https://doaj.org/article/ba82b901892b43109a92a0ea6c402445
Publikováno v:
Journal of Alzheimer's Disease. 50:645-658
Studies of presenilin (PSEN) gene mutations producing early onset Alzheimer's disease (AD) have helped elucidate the pathogenic mechanisms of dementia and guided clinical trials of potential therapeutic interventions. Although familial and sporadic f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609283e28e1d1b12720c46d08a4d1cd0
https://doi.org/10.3233/jad-150757
https://doi.org/10.3233/jad-150757
Autor:
Steven Clarke, Alex E. Roher, Michael R. Sierks, Geidy E. Serrano, Tyler A. Kokjohn, Thomas G. Beach, Marwan S. Sabbagh, Chera L. Maarouf
The amyloid cascade hypothesis of Alzheimer's disease (AD) proposes amyloid- β (Aβ) is a chief pathological element of dementia. AD therapies have targeted monomeric and oligomeric Aβ 1-40 and 1-42 peptides. However, alternative APP proteolytic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521b844a41755667ec6e37b1fcd368f3
https://europepmc.org/articles/PMC5688956/
https://europepmc.org/articles/PMC5688956/
Publikováno v:
Neurological Disorders and Therapeutics. 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3bdb86c416c04be03be949604a5edd7
https://doi.org/10.15761/ndt.1000116
https://doi.org/10.15761/ndt.1000116
Autor:
Marwan N. Sabbagh, Tyler A. Kokjohn, Walter M. Kalback, Alex E. Roher, Chera L. Maarouf, Robert Vassar, Charisse M. Whiteside, Mimi Macias, Thomas G. Beach
Publikováno v:
Biochemistry Insights
Biochemistry Insights, Vol 2013, Iss 6, Pp 1-10 (2013)
Biochemistry Insights, Vol 6 (2013)
Biochemistry Insights, Vol 2013, Iss 6, Pp 1-10 (2013)
Biochemistry Insights, Vol 6 (2013)
Transgenic (Tg) mouse models of Alzheimer's disease (AD) have been extensively used to study the pathophysiology of this dementia and to test the efficacy of drugs to treat AD. The 5XFAD Tg mouse, which contains two presenilin-1 and three amyloid pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909f31bd906ece1f7294b4b1b562fea2
http://europepmc.org/articles/PMC4154482
http://europepmc.org/articles/PMC4154482
Autor:
Jesse M. Hunter, Emma Rodriguez, Walter M. Kalback, Michael Malek-Ahmadi, Alex E. Roher, Ian D. Daugs, Marwan N. Sabbagh, Tyler A. Kokjohn, Thomas G. Beach, Charisse M. Whiteside, Sandra Jacobson, Chera L. Maarouf
Publikováno v:
Journal of Neurotrauma. 30:981-997
Dementia pugilistica (DP), a suite of neuropathological and cognitive function declines after chronic traumatic brain injury (TBI), is present in approximately 20% of retired boxers. Epidemiological studies indicate TBI is a risk factor for neurodege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4532f8472a0058bf74c3fdf1b664e4de
https://doi.org/10.1089/neu.2012.2699
https://doi.org/10.1089/neu.2012.2699
Autor:
Chera L Maarouf, Thomas G Beach, Charles H Adler, Holly A Shill, Marwan N Sabbagh, Terence Wu, Douglas G Walker, Tyler A Kokjohn, Alex E Roher, Arizona PD Consortium
Publikováno v:
Neurological Research. 34:669-676
Parkinson's disease (PD) afflicts approximately 1-2% of the population over 50 years of age. No cures or effective modifying treatments exist and clinical diagnosis is currently confounded by a lack of definitive biomarkers. We sought to discover pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480cfec32e6e64f1c0470490b1d2cb1f
https://doi.org/10.1179/1743132812y.0000000063
https://doi.org/10.1179/1743132812y.0000000063
Autor:
John Lopez, Tyler A. Kokjohn, Alex E. Roher, Ian D. Daugs, Lucia I. Sue, Dean C. Luehrs, Jesse M. Hunter, Walter M. Kalback, Eduardo M. Castaño, Thomas G. Beach, Gregory D. Van Vickle, Chera L. Maarouf, Daniel C. Brune
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1812:1508-1514
Amyloid-β (Aβ) peptides are intimately involved in the inflammatory pathology of atherosclerotic vascular disease (AVD) and Alzheimer's disease (AD). Although substantial amounts of these peptides are produced in the periphery, their role and signi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effea2d41b451e7f192686d4f7e69a77
https://doi.org/10.1016/j.bbadis.2011.07.004
https://doi.org/10.1016/j.bbadis.2011.07.004
Autor:
Jesse M. Hunter, Tyler A. Kokjohn, Ian D. Daugs, Thomas G. Beach, Alex E. Roher, Marwan N. Sabbagh, Chera L. Maarouf
Publikováno v:
Journal of Alzheimer's Disease. 24:315-325
The field of Alzheimer's disease (AD) research eagerly awaits the results of a large number of Phase III clinical trials that are underway to investigate the effectiveness of anti-amyloid-β (Aβ) immunotherapy for AD. In this case report, we review
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fe25144644045770b02c0c80087c8f
https://doi.org/10.3233/jad-2011-101809
https://doi.org/10.3233/jad-2011-101809
Autor:
Zsolt Garami, Donald J. Connor, Marek Belohlavek, Thomas G. Beach, Suzanne L. Tyas, Alex E. Roher, Tyler A. Kokjohn, Marwan N. Sabbagh, Mark R. Emmerling, Chera L. Maarouf, Linda Vedders
Publikováno v:
Alzheimer's & Dementia. 7:445-455
Background Multiple lines of evidence suggest that cardiovascular co-morbidities hasten the onset of Alzheimer’s disease (AD) or accelerate its course. Methods To evaluate the utility of cerebral vascular physical function and/or condition paramete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb6fa51a145e049c8a1d499d652fb49
https://doi.org/10.1016/j.jalz.2010.09.002
https://doi.org/10.1016/j.jalz.2010.09.002