Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tyler A. Godek"'
Autor:
Ryan S. O’Dell, Adam P. Mecca, Ming-Kai Chen, Mika Naganawa, Takuya Toyonaga, Yihuan Lu, Tyler A. Godek, Joanna E. Harris, Hugh H. Bartlett, Emmie R. Banks, Victoria L. Kominek, Wenzhen Zhao, Nabeel B. Nabulsi, Jim Ropchan, Yunpeng Ye, Brent C. Vander Wyk, Yiyun Huang, Amy F. T. Arnsten, Richard E. Carson, Christopher H. van Dyck
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)
Abstract Background Attempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in Alzheimer’s disease (AD) have thus far been limited to small numbers of postmortem studies. Aβ plaque burden is not well-correlated with indices of clini
Externí odkaz:
https://doaj.org/article/bf54db7ecf0047c889104bb1723e1147
Autor:
Adam P. Mecca, Julia W. McDonald, Hannah R. Michalak, Tyler A. Godek, Joanna E. Harris, Erika A. Pugh, Emily C. Kemp, Ming-Kai Chen, Arash Salardini, Nabeel B. Nabulsi, Keunpoong Lim, Yiyun Huang, Richard E. Carson, Stephen M. Strittmatter, Christopher H. van Dyck
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
Abstract Background Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers. We u
Externí odkaz:
https://doaj.org/article/fea1a7ff0aba43c19ea7e0af4b8ca35a
Autor:
Ryan S. O'Dell, Joanna E. Harris, Christopher H. van Dyck, Victoria L. Kominek, Ming-Kai Chen, Brent C. Vander Wyk, Richard E. Carson, Nabeel Nabulsi, Hugh H. Bartlett, Takuya Toyonaga, Emmie R. Banks, Jim Ropchan, Yiyun Huang, Mika Naganawa, Yihuan Lu, Wenzhen Zhao, Adam P. Mecca, Tyler A. Godek, Yunpeng Ye, Amy F.T. Arnsten
Publikováno v:
The American Journal of Geriatric Psychiatry. 29:S37-S40
Introduction Synaptic loss is an early pathology in Alzheimer's disease (AD) and the major structural correlate of cognitive impairment. We have recently demonstrated extensive synaptic loss in the medial temporal and neocortical regions of participa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd0954c0830e43e6e5363af3daf2d49
https://doi.org/10.1016/j.jagp.2021.01.034
https://doi.org/10.1016/j.jagp.2021.01.034
Autor:
Wenzhen Zhao, Christopher H. van Dyck, Ryan S. O'Dell, Tyler A. Godek, Mika Naganawa, Joanna E. Harris, Ming-Kai Chen, Brent C. Vander Wyk, Richard E. Carson, Pradeep Varma, Hugh H. Bartlett, Adam P. Mecca, Takuya Toyonaga, Nabeel Nabulsi, Yiyun Huang, Amy F.T. Arnsten
Publikováno v:
Alzheimer's & Dementia
Introduction Synaptic loss is a robust and consistent pathology in Alzheimer's disease (AD) and the major structural correlate of cognitive impairment. Positron emission tomography (PET) imaging of synaptic vesicle glycoprotein 2A (SV2A) has emerged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9961eafe67509e671192d176b6e9ed
https://doi.org/10.1002/alz.12097
https://doi.org/10.1002/alz.12097
Autor:
Alzheimer's Disease Neuroimaging Initiative, Erika A Pugh, Marcia C. Mecca, Julia W. McDonald, Adam P. Mecca, Christopher H. van Dyck, Hugh H. Bartlett, Srinath Ramanan, Tyler A. Godek, Emily C Kemp, Megan K Ebner
Publikováno v:
Am J Geriatr Psychiatry
HMG-CoA reductase inhibitors (statins) have been proposed to both positively and negatively alter the cognitive trajectory of older adults. To further investigate the disparate findings (provided by the FDA black box warning, adverse event reports, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e258a87848fa3bf3b3f47ae6ff0e9f
https://doi.org/10.1016/j.jagp.2019.11.003
https://doi.org/10.1016/j.jagp.2019.11.003
Autor:
Arash Salardini, Emily C Kemp, Yiyun Huang, Erika A Pugh, Nabeel Nabulsi, Adam P. Mecca, Keunpoong Lim, Ming-Kai Chen, Richard E. Carson, Joanna E. Harris, Christopher H. van Dyck, Stephen M. Strittmatter, Tyler A. Godek, Hannah R. Michalak, Julia W. McDonald
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers. We utilized t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185ac5b856268819588b67bd5ea1b92f
https://doaj.org/article/fea1a7ff0aba43c19ea7e0af4b8ca35a
https://doaj.org/article/fea1a7ff0aba43c19ea7e0af4b8ca35a
Autor:
Amy F.T. Arnsten, Brent C. Vander, Christopher H. van Dyck, Hugh H. Bartlett, Kelly Rogers, Emmie R. Banks, Takuya Toyonaga, Ryan S. O'Dell, Jean-Dominique Gallezot, Tyler A. Godek, Jim Ropchan, Joanna E. Harris, Yiyun Huang, Mika Naganawa, Ming-Kai Chen, Nabeel Nabulsi, Gessica S. Ni, Paul Emery, Adam P. Mecca, Richard E. Carson, Wenzhen Zhao
Publikováno v:
Neurobiol Aging
Sites of early neuropathologic change provide important clues regarding the initial clinical features of Alzheimer's disease (AD). We have shown significant reductions in hippocampal synaptic density in participants with AD, consistent with the early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6231ec8cf4a389afe9c8654b1e05898b
https://europepmc.org/articles/PMC8761170/
https://europepmc.org/articles/PMC8761170/
Autor:
Hugh H. Bartlett, Mika Naganawa, Takuya Toyonaga, Joanna E. Harris, Jim Ropchan, Yunpeng Ye, Amy F.T. Arnsten, Yiyun Huang, Brent C. Vander Wyk, Richard E. Carson, Nabeel Nabulsi, Yihuan Lu, Victoria L. Kominek, Ming-Kai Chen, Wenzhen Zhao, Ryan S. O'Dell, Adam P. Mecca, Christopher H. van Dyck, Tyler A. Godek, Emmie R. Banks
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)
Background Attempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in Alzheimer’s disease (AD) have thus far been limited to small numbers of postmortem studies. Aβ plaque burden is not well-correlated with indices of clinical sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d9dbfe7e720cef0287462029e271f2
https://doi.org/10.1186/s13195-020-00742-y
https://doi.org/10.1186/s13195-020-00742-y
Autor:
Ryan S. O'Dell, Emily Laltoo, Christopher H. van Dyck, Sarah Savoia, Ansel T. Hillmer, Adam P. Mecca, Keunpoong Lim, Nabeel Nabulsi, Jim Ropchan, Richard E. Carson, Yiyun Huang, Joanna E. Harris, Tyler A. Godek, Stephen M. Strittmatter, Arsalan Hashemiaghdam, Kelly P. Cosgrove, Arash Salardini
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa9bf856b99168299efa995157915d89
https://doi.org/10.1002/alz.037792
https://doi.org/10.1002/alz.037792
Autor:
Emmie R. Banks, Amy F.T. Arnsten, Joanna E. Harris, Yunpeng Ye, Christopher H. van Dyck, Brent C. Vander Wyk, Richard E. Carson, Wenzhen Zhao, Ryan S. O'Dell, Adam P. Mecca, Yiyun Huang, Yihuan Lu, Tyler A. Godek, Victoria L. Kominek, Ming-Kai Chen, Nabeel Nabulsi, Mika Naganawa, Pradeep Varma, Hugh H. Bartlett, Takuya Toyonaga, Jim Ropchan
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3edbf3e42cc8a19d14309675ea1d771d
https://doi.org/10.1002/alz.043631
https://doi.org/10.1002/alz.043631