A Discrete Domain of the Human TrkB Receptor Defines the Binding Sites for BDNF and NT-4

Autor: Naylor, Ruth L, Robertson, Alan G.S, Allen, Shelley J, Sessions, Richard B, Clarke, Anthony R, Mason, Grant G.F, Burston, Judy J, Tyler, Sue J, Wilcock, Gordon K, Dawbarn, David

Publikováno v: In Biochemical and Biophysical Research Communications 1 March 2002 291(3):501-507

Recombinant human nerve growth factor for clinical trials: protein expression, purification, stability and characterisation of binding to infusion pumps

Autor: Allen, Shelley J ^*, Robertson, Alan G.S, Tyler, Sue J, Wilcock, Gordon K, Dawbarn, David

Publikováno v: In Journal of Biochemical and Biophysical Methods 2001 47(3):239-255

Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery

Autor: Shoemark, Deborah K, Williams, Christopher, Fahey, Mark S, Watson, Judy J, Tyler, Sue J, Scoltock, Simon J, Ellis, Rosamund, Wickendon, Elaine, Burton, Antony J, Hemmings, Jennifer Luise L, Bailey, Christopher D, Dawbarn, David, Jane, David E, Willis, Chris L, Sessions, Richard B, Allen , Shelley J, Crump, Matthew P

Publikováno v: Shoemark, D K, Williams, C, Fahey, M S, Watson, J J, Tyler, S J, Scoltock, S J, Ellis, R, Wickendon, E, Burton, A J, Hemmings, J L L, Bailey, C D, Dawbarn, D, Jane, D E, Willis, C L, Sessions, R B, Allen, S J & Crump, M P 2015, ' Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery ', Journal of Medicinal Chemistry, vol. 58, no. 2, pp. 767-777 . https://doi.org/10.1021/jm501307e

The tyrosine kinase A (TrkA) receptor is a validated therapeutic intervention point for a wide range of conditions. TrkA activation by nerve growth factor (NGF) binding the second extracellular immunoglobulin (TrkAIg2) domain, triggers intracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2642::42630e8d534f8036916a0099b5032282
https://hdl.handle.net/1983/ef88c645-344d-43d5-af15-69ecf8224f68

Design and Nuclear MagneticResonance (NMR) StructureDetermination of the Second Extracellular Immunoglobulin TyrosineKinase A (TrkAIg2) Domain Construct for Binding Site Elucidation inDrug Discovery.

Autor: Shoemark, Debbie K., Williams, Christopher, Fahey, Mark S., Watson, Judy J., Tyler, Sue J., Scoltock, Simon J., Ellis, Rosamund Z., Wickenden, Elaine, Burton, Antony J., Hemmings, Jennifer L., Bailey, Christopher D., Dawbarn, David, Jane, David E., Willis, Christine L., Sessions, Richard B., Allen, Shelley J., Crump, Matthew P.

Publikováno v: Journal of Medicinal Chemistry; Jan2015, Vol. 58 Issue 2, p767-777, 11p

Human ProNGF: biological effects and binding profiles at TrkA, P75^NTR and sortilin.

Autor: Clewes, Oliver, Fahey, Mark S., Tyler, Sue J., Watson, Judy J., Heon Seok, Catania, Caterina, Kwangwook Cho, Dawbarn, David, Allen, Shelley J.

Publikováno v: Journal of Neurochemistry; Nov2008, Vol. 107 Issue 4, p1124-1135, 12p, 1 Black and White Photograph, 3 Graphs