Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Tyler, DJ"'
Autor:
Hazlehurst, JM, Lim, TR, Charlton, C, Miller, JJ, Gathercole, LL, Cornfield, T, Nikolaou, N, Harris, SE, Moolla, A, Othonos, N, Heather, LC, Marjot, T, Tyler, DJ, Carr, C, Hodson, L, McKeating, J, Tomlinson, JW
Background and aims Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver condition. It is tightly associated with an adverse metabolic phenotype (including obesity and type 2 diabetes) as well as with obstructive sleep apnoea (O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfce37250d4b1776da0044738b6b008
https://doi.org/10.1016/j.metop.2022.100177
https://doi.org/10.1016/j.metop.2022.100177
Autor:
Miller, JJ, Valkovič, L, Kerr, M, Timm, KN, Watson, WD, Lau, JYC, Tyler, A, Rodgers, C, Bottomley, PA, Heather, LC, Tyler, DJ
Publikováno v:
Miller, J J, Valkovič, L, Kerr, M, Timm, K N, Watson, W D, Lau, J Y C, Tyler, A, Rodgers, C, Bottomley, P A, Heather, L C & Tyler, D J 2021, ' Rapid, B 1-insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux ', Magnetic Resonance in Medicine, vol. 85, no. 6, pp. 2978-2991 . https://doi.org/10.1002/mrm.28647
Purpose: Phosphorus saturation-transfer experiments can quantify metabolic fluxes non-invasively. Typically, the forward flux through the creatine-kinase reaction is investigated by observing the decrease in phosphocreatine (PCr) after saturation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79c935b299a76caa48d75d64af9b8a1
https://pure.au.dk/ws/files/274252216/Magnetic_Resonance_in_Med_2021_Miller_Rapid_u2010insensitive_dual_u2010band_quasi_u2010adiabatic_saturation_transfer_with_optimal.pdf
https://pure.au.dk/ws/files/274252216/Magnetic_Resonance_in_Med_2021_Miller_Rapid_u2010insensitive_dual_u2010band_quasi_u2010adiabatic_saturation_transfer_with_optimal.pdf
Autor:
Dodd, MS, Sousa Fialho, MDL, Montes Aparicio, CN, Kerr, M, Timm, KN, Griffin, JL, Luiken, JJFP, Glatz, JFC, Tyler, DJ, Heather, LC
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • HIF-1α is activated following myocardial infarction, and is a critical transcription factor promoting survival in hypoxia. • Type 2 diabetes blunts HIF-1α activation in ischemia and downstream adaptation to hyp
Highlights • HIF-1α is activated following myocardial infarction, and is a critical transcription factor promoting survival in hypoxia. • Type 2 diabetes blunts HIF-1α activation in ischemia and downstream adaptation to hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b03523fcf1d2ee305e6c87916135e75
http://europepmc.org/articles/PMC6115650
http://europepmc.org/articles/PMC6115650
Autor:
Tyler, DJ
All animals have a protective covering of skin, generally supplemented by an additional layer of fur, scales, feathers or body armour. Consequently, we are surrounded by instructive models of protection – applicable to a great variety of environmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______128::010f0c99a0457c9d1ad8b1d99d282b50
https://e-space.mmu.ac.uk/619092/
https://e-space.mmu.ac.uk/619092/
Purpose Echo planar imaging is an attractive rapid imaging readout that can image hyperpolarized compounds in vivo. By alternating the sign of the phase encoding gradient waveform, spatial offsets arising from uncertain frequency shifts can be determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f1f87d0fe50c9e591d9beb01f57791ee
https://ora.ox.ac.uk/objects/uuid:fa1f00d7-ad14-4839-9aa1-6ccb69071ae8
https://ora.ox.ac.uk/objects/uuid:fa1f00d7-ad14-4839-9aa1-6ccb69071ae8
Autor:
Schroeder, MA, Atherton, HJ, Ball, DR, Cole, MA, Heather, LC, Griffin, JL, Clarke, K, Radda, GK, Tyler, DJ
The Krebs cycle plays a fundamental role in cardiac energy production and is often implicated in the energetic imbalance characteristic of heart disease. In this study, we measured Krebs cycle flux in real time in perfused rat hearts using hyperpolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e72a8c963c23553590163f54cb3afea2
https://ora.ox.ac.uk/objects/uuid:fc6098eb-94ac-4064-91df-fb86b75be282
https://ora.ox.ac.uk/objects/uuid:fc6098eb-94ac-4064-91df-fb86b75be282
Autor:
Holloway, CJ, Edwards, LM, Emmanuel, Y, Cochin, L, Tyler, DJ, Robson, M, Szmigielski, C, Knight, N, Murray, AJ, Saxby, BK, Francis, JM, Neubauer, S, Clarke, K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cc82d821e335e226f5dbe5ff0f728a55
https://ora.ox.ac.uk/objects/uuid:a9a60c08-96f9-4ac4-a7c2-1fc14714741a
https://ora.ox.ac.uk/objects/uuid:a9a60c08-96f9-4ac4-a7c2-1fc14714741a