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pro vyhledávání: '"Tyelor S. Reynolds"'
Autor:
Sanket J. Mishra, Tyelor S. Reynolds, Taylor Merfeld, Maurie Balch, Shuxia Peng, Junpeng Deng, Robert Matts, Brian S. J. Blagg
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1870-1878
The heat shock protein 90 (Hsp90) family of molecular chaperones mediates the folding and activation of client proteins associated with all 10 hallmarks of cancer. Herein, the design, synthesis, and biological validation of Hsp90α-selective inhibito