2-(4,5-Dihydro-1H-imidazol-2-yl)indazole (indazim) derivatives as selective I 2 imidazoline receptor ligands

Autor: Saczewski, F, Hudson, A.L, Tyacke, R.J, Nutt, D.J, Man, J, Tabin, P, Saczewski, J

Publikováno v: In European Journal of Pharmaceutical Sciences 2003 20(2):201-208

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline Binding Sites in Rhesus Brain

Autor: Parker, C.A., Nabulsi, N., Holden, D., Lin, S.-F., Cass, T., Labaree, D., Kealey, S., Gee, A.D., Husbands, S.M., Quelch, D., Carson, R.E., Nutt, D.J., Huang, Y., Tyacke, R.J.

Publikováno v: Parker, C A, Nabulsi, N, Holden, D, Lin, S-F, Cass, T, Labaree, D, Kealey, S, Gee, A D, Husbands, S M, Quelch, D, Carson, R E, Nutt, D J, Huang, Y & Tyacke, R J 2014, ' Evaluation of 11 C-BU99008, a PET Ligand for the Imidazoline Binding Sites in Rhesus Brain ', The Journal of Nuclear Medicine, vol. 55, no. 5, pp. 838-844 . https://doi.org/10.2967/jnumed.113.131854

The development of a PET radioligand selective for I2-imidazoline binding sites (I2BS) would enable, for the first time, specific, measurable in vivo imaging of this target protein, along with assessment of alterations in expression patterns of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1378::9de3505d8b035b018608fb9499be2029
https://purehost.bath.ac.uk/ws/files/121678593/11C_BU99008_rhesusmonkey.pdf

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Are prescribed benzodiazepines likely to affect the availability of the 18 kDa translocator protein (TSPO) in PET studies?

Autor: Kalk, N.J., Owen, D.R., Tyacke, R.J., Reynolds, R., Rabiner, E.A., Lingford‐hughes, A.R., Parker, C.A.

Publikováno v: Synapse; Dec2013, Vol. 67 Issue 12, p909-912, 4p