Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Txnip, thioredoxin interacting protein"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Diabetic kidney disease (DKD) is a prevalent and severe complications of diabetes and serves as the primary cause of end-stage kidney disease (ESKD) globally. Increasing evidence indicates that renal inflammation is critical in the pathogenesis of DK
Externí odkaz:
https://doaj.org/article/1ea812f3694c4a7cb04c627efe126753
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Diabetic retinopathy (DR) is a common complication of diabetes mellitus and has been considered a microvascular disease for a long time. However, recent evidence suggests that diabetic retinal neurodegeneration (DRN), which manifests as neuronal apop
Externí odkaz:
https://doaj.org/article/76ffd4991f1f4f3cbf2ff6507b694994
Autor:
Wenxiu Lai, Yulin Mo, Dongtao Wang, Ying Zhong, Lujiao Lu, Jiajia Wang, Liao Cui, Yanzhi Liu, Yajun Yang
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Impaired bone formation is the main characteristics of glucocorticoid (GC)-induced osteoporosis (GIO), which can be ameliorated by tanshinol, an aqueous polyphenol isolated from Salvia miltiorrhiza Bunge. However, the underlying mechanism is still no
Externí odkaz:
https://doaj.org/article/11b5205908c74ad1985eb9ae7232768f
Autor:
Yiting Chen, Jieling Ning, Wenjie Cao, Shuanglian Wang, Tao Du, Jiahui Jiang, Xueping Feng, Bin Zhang
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Thioredoxin-interacting protein (TXNIP) is a thioredoxin-binding protein that can mediate oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of the thioredoxin system. TXNIP is important because of its wide
Externí odkaz:
https://doaj.org/article/b0b3f9f10ad241caa0e5d656fee63436
Autor:
Gaelle Filhoulaud, Fadila Benhamed, Patrick Pagesy, Caroline Bonner, Yann Fardini, Anissa Ilias, Jamileh Movassat, Anne-Françoise Burnol, Sandra Guilmeau, Julie Kerr-Conte, François Pattou, Tarik Issad, Catherine Postic
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Thioredoxin interacting protein (TxNIP), which strongly responds to glucose, has emerged as a central mediator of glucotoxicity in pancreatic β cells. TxNIP is a scaffold protein interacting with target proteins to inhibit or stimulate their activit
Externí odkaz:
https://doaj.org/article/9c5a66758ef54b9384f0c41f8fdc18bd
Autor:
Chang Jia, Jian Xiao, Abdullah Al Mamun, Fahad Munir, Ilma Monalisa, Kailiang Zhou, Yanqing Wu
Publikováno v:
Journal of Advanced Research, Vol 28, Iss, Pp 97-109 (2021)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Highlights • Neuroinflammation plays a key role in the secondary injury of acute SCI. • Pyroptosis is defined as a newly programmed cell death. • Recent studies show that pyroptosis play a key role in SCI. • Some molec
Highlights • Neuroinflammation plays a key role in the secondary injury of acute SCI. • Pyroptosis is defined as a newly programmed cell death. • Recent studies show that pyroptosis play a key role in SCI. • Some molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58aaa585b7dc4e7f4e03b92a67b2a015
http://www.sciencedirect.com/science/article/pii/S2090123220301880
http://www.sciencedirect.com/science/article/pii/S2090123220301880
Autor:
Jie Cai, Xiaoge Zhang, Peng Chen, Yang Li, Songzi Liu, Qian Liu, Hanyong Zhang, Zhuyin Wu, Ke Song, Jianmiao Liu, Bo Shan, Yong Liu
Publikováno v:
The Journal of Biological Chemistry
Hepatic ischemia/reperfusion (I/R) injury is an inflammation-mediated process arising from ischemia/reperfusion-elicited stress in multiple cell types, causing liver damage during surgical procedures and often resulting in liver failure. Endoplasmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86338028f5113cd46609ec4ba5e153f
http://europepmc.org/articles/PMC8760522
http://europepmc.org/articles/PMC8760522
Autor:
Luisa Lange, S Reime, Thea Hüsing, Oliver Thews, Anne Riemann, Kristin Jarosik, Mandy Rauschner
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1275-1288 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1275-1288 (2021)
Background: The acidic extracellular environment of tumors has been shown to affect the malignant progression of tumor cells by modulating proliferation, cell death or metastatic potential. The aim of the study was to analyze whether acidosis-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea52fe115a2053b798f64026fcc48e67
https://pubmed.ncbi.nlm.nih.gov/34781085
https://pubmed.ncbi.nlm.nih.gov/34781085
Publikováno v:
The Journal of Biological Chemistry
Traditionally, lipolysis has been regarded as an enzymatic activity that liberates fatty acids as metabolic fuel. However, recent work has shown that novel substrates, including a variety of lipid compounds such as fatty acids and their derivatives,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843afc812038c7071cb5c29c54353e0a
http://europepmc.org/articles/PMC7949114
http://europepmc.org/articles/PMC7949114
Publikováno v:
World Allergy Organization Journal, Vol 13, Iss 10, Pp 100473-(2020)
The World Allergy Organization Journal
The World Allergy Organization Journal
Background Allergic rhinitis (AR) is a type I hypersensitivity mediated by IgE in the nose. Thioredoxin-interacting protein (TXNIP) plays a pivotal role in the process of producing reactive oxygen species (ROS). Resveratrol is a TXNIP inhibitor. None
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7016ba0f407569cb293c530888ec2c6b
http://www.sciencedirect.com/science/article/pii/S1939455120303768
http://www.sciencedirect.com/science/article/pii/S1939455120303768