ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways.

Autor: Rubina A; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Patel M; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Nightingale K; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom., Potts M; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom., Fielding CA; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Kollnberger S; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Lau B; Centre for Virus Research, University of Glasgow, Glasgow G12 8TA, United Kingdom., Ladell K; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Miners KL; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Nichols J; Centre for Virus Research, University of Glasgow, Glasgow G12 8TA, United Kingdom., Nobre L; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom., Roberts D; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Trinca TM; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Twohig JP; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Vlahava VM; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Davison AJ; Centre for Virus Research, University of Glasgow, Glasgow G12 8TA, United Kingdom., Price DA; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Tomasec P; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Wilkinson GWG; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Weekes MP; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom., Stanton RJ; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Wang ECY; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Aug 15; Vol. 120 (33), pp. e2303155120. Date of Electronic Publication: 2023 Aug 10.

Activation of naïve CD4 ⁺ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 ⁺ T cells.

Autor: Twohig JP; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, Wales, UK.; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK., Cardus Figueras A; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, Wales, UK.; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK., Andrews R; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK., Wiede F; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia., Cossins BC; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, Wales, UK.; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK., Derrac Soria A; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, Wales, UK.; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK., Lewis MJ; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary's School of Medicine & Dentistry, London, UK., Townsend MJ; Biomarker Discovery OMNI, Genentech Research & Early Development, South San Francisco, CA, USA., Millrine D; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, Wales, UK.; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK., Li J; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Department of Microbiology, Monash University, Clayton, Victoria, Australia., Hill DG; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, Wales, UK.; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK., Uceda Fernandez J; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, Wales, UK.; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK., Liu X; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, Wales, UK.; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK., Szomolay B; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, Wales, UK.; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK., Pepper CJ; Division of Cancer & Genetics, School of Medicine, Cardiff University, Cardiff, UK.; Brighton and Sussex Medical School, University of Sussex, Brighton, UK., Taylor PR; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, Wales, UK.; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK., Pitzalis C; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary's School of Medicine & Dentistry, London, UK., Tiganis T; Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia., Williams NM; Division of Psychological Medicine & Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Jones GW; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, Wales, UK.; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK.; School of Cellular and Molecular Medicine, Biomedical Sciences Building, University Walk, University of Bristol, Bristol, UK., Jones SA; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, Wales, UK. JonesSA@cf.ac.uk.; Systems Immunity University Research Institute, Cardiff University, Cardiff, UK. JonesSA@cf.ac.uk.

Publikováno v: Nature immunology [Nat Immunol] 2019 Apr; Vol. 20 (4), pp. 458-470. Date of Electronic Publication: 2019 Mar 19.

Death Receptor 3 Promotes Chemokine-Directed Leukocyte Recruitment in Acute Resolving Inflammation and Is Essential for Pathological Development of Mesothelial Fibrosis in Chronic Disease.

Autor: Perks WV; Department of Medical Microbiology and Infectious Disease, Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom., Singh RK; Department of Medical Microbiology and Infectious Disease, Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom., Jones GW; Department of Rheumatology, Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom., Twohig JP; Department of Medical Microbiology and Infectious Disease, Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom; Department of Rheumatology, Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom., Williams AS; Department of Rheumatology, Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom., Humphreys IR; Department of Medical Microbiology and Infectious Disease, Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom., Taylor PR; Department of Rheumatology, Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom., Jones SA; Department of Rheumatology, Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom., Wang ECY; Department of Medical Microbiology and Infectious Disease, Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom. Electronic address: wangec@cf.ac.uk.

Publikováno v: The American journal of pathology [Am J Pathol] 2016 Nov; Vol. 186 (11), pp. 2813-2823. Date of Electronic Publication: 2016 Sep 21.

The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4⁺ and CD8⁺ T-cell immunity.

Autor: Twohig JP; Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK., Marsden M, Cuff SM, Ferdinand JR, Gallimore AM, Perks WV, Al-Shamkhani A, Humphreys IR, Wang EC

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2012 Aug; Vol. 26 (8), pp. 3575-86. Date of Electronic Publication: 2012 May 16.

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.

Autor: Jones GW; Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, Wales, UK., Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2011 Jan; Vol. 25 (1), pp. 409-19. Date of Electronic Publication: 2010 Sep 08.