Differential lncRNA expression profiling of cognitive function in middle and old aged monozygotic twins using generalized association analysis

Autor: Jesper Lund, Martin Jakob Larsen, Qihua Tan, Weilong Li, Jan Baumbach, Lene Christiansen, Shuxia Li, Jonas Mengel-From, Kaare Christensen, Afsaneh Mohammadnejad, Tanja Maria Michel, Jacob v. B. Hjelmborg

Publikováno v: Mohammadnejad, A, Baumbach, J, Li, W, Lund, J, Larsen, M J, Li, S, Mengel-From, J, Sheldrick-Michel, T M, Christiansen, L, Christensen, K, Hjelmborg, J & Tan, Q 2021, ' Differential lncRNA expression profiling of cognitive function in middle and old aged monozygotic twins using generalized association analysis ', Journal of Psychiatric Research, vol. 140, pp. 197-204 . https://doi.org/10.1016/j.jpsychires.2021.05.074

Cognitive impairment is the most prominent symptom in neurodegenerative disorders affecting quality of life and mortality. However, despite years of research, the molecular mechanism underlying the regulation of cognitive function and its impairment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6011b00a9d3115cc4a9d69d46e459d
https://portal.findresearcher.sdu.dk/da/publications/e9299092-164c-418a-a1dd-61aad0e0e8a7

Heritability of caffeine metabolism:Environmental effects masking genetic effects on CYP1A2 activity but not on NAT2

Autor: Matthaei, Johannes, Tzvetkov, Mladen V, Strube, Jakob, Sehrt, Daniel, Sachse-Seeboth, Cordula, Hjelmborg, Jacob v. B., Möller, Sören, Halekoh, Ulrich, Hofmann, Ute, Schwab, Matthias, Kerb, Reinhold, Brockmöller, Jürgen

Publikováno v: Matthaei, J, Tzvetkov, M V, Strube, J, Sehrt, D, Sachse-Seeboth, C, Hjelmborg, J V B, Möller, S, Halekoh, U, Hofmann, U, Schwab, M, Kerb, R & Brockmöller, J 2016, ' Heritability of caffeine metabolism : Environmental effects masking genetic effects on CYP1A2 activity but not on NAT2 ', Clinical Pharmacology & Therapeutics, vol. 100, no. 6, pp. 606-616 . https://doi.org/10.1002/cpt.444

Heritability of caffeine pharmacokinetics and cytochrome P450 1A2 (CYP1A2) activity is controversial. Here, we analyzed the pharmacokinetics of caffeine, an in vivo probe drug for CYP1A2 and arylamine N-acetyltransferase 2 (NAT2) activity, in monozyg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3062::1ff4e5cd2dd5d73af006082d3f0cada4
https://portal.findresearcher.sdu.dk/da/publications/505827fa-2eef-4b06-a5cf-bf68b63fa2b3

Sex differences in risk and heritability estimates on primary knee osteoarthritis leading to total knee arthroplasty:a nationwide population based follow up study in Danish twins

Autor: Lars Brandt, Søren Overgaard, Søren Glud Skousgaard, Axel Skytthe, Sören Möller

Publikováno v: Skousgaard, S G, Skytthe, A, Möller, S, Overgaard, S & Brandt, L 2016, ' Sex differences in risk and heritability estimates on primary knee osteoarthritis leading to total knee arthroplasty : a nationwide population based follow up study in Danish twins ', Arthritis Research & Therapy
, vol. 18, 46 . https://doi.org/10.1186/s13075-016-0939-8
Arthritis Research & Therapy

Background: Symptomatic knee osteoarthritis is a highly age and sex associated complex disease. Little is known about the causes behind this age and sex associated increase, or if genetic and environmental factors impacts differently by gender. Our s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b7db53d12fafac1df58fe7d0253c0a
https://findresearcher.sdu.dk:8443/ws/files/123311794/Sex_differences_in_risk_and_heritability_estimates_on_primary_knee_osteoarthritis.pdf

Prefrontal and Striatal Volumes in Monozygotic Twins Concordant and Discordant for Schizophrenia

Autor: Philip McGuire, Kazunori Matsumoto, Ulrich Ettinger, Charmaine Borg, Sheena Owens, Timothea Toulopoulou, Neeltje E.M. van Haren, Claire Orrells, Mei-Hua Hall, Anne Schmechtig, Veena Kumari, Robin M. Murray, Marco Picchioni

Publikováno v: Schizophrenia Bulletin, 38(1), 192-203. Oxford University Press

Frontostriatal networks mediating important cognitive and motor functions have been shown to be abnormal structurally and functionally in schizophrenia. However, the influence of genetic risk for schizophrenia on structural abnormalities in these are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e598b0f9c6a20c6d3b0dbad8223845
https://doi.org/10.1093/schbul/sbq060

Lung cancer, genetic predisposition and smoking: the Nordic Twin Study of Cancer

Autor: Lorelei A. Mucci, Thomas H. Scheike, Kaare Christensen, Klaus K. Holst, Jacob v. B. Hjelmborg, Kamila Czene, Axel Skytthe, Julia Kutschke, Jaakko Kaprio, Eero Pukkala, Hans-Olov Adami, Jennifer R. Harris, Tellervo Korhonen

Publikováno v: Hjelmborg, J V B, Korhonen, T, Holst, K, Skytthe, A, Pukkala, E, Kutschke, J, Harris, J, Mucci, L, Christensen, K, Czene, K, Adami, H-O, Scheike, T H & Kaprio, J 2017, ' Lung cancer, genetic predisposition and smoking: the Nordic Twin Study of Cancer ', Thorax, vol. 72, no. 11, pp. 1021-1027 . https://doi.org/10.1136/thoraxjnl-2015-207921

Background We aimed to disentangle genetic and environmental causes in lung cancer while considering smoking status. Methods Four Nordic twin cohorts (43 512 monozygotic (MZ) and 71 895 same sex dizygotic (DZ) twin individuals) had smoking data befor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8b1c6afab7f49774508e4029e5dd93
https://pubmed.ncbi.nlm.nih.gov/29054888