A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica

Autor: James Irving, Rn, Pike, Siyaguna S, Pm, Smooker, Tw, Spithill, Jc, Whisstock

Publikováno v: Europe PubMed Central

The trematode Fasciola hepatica secretes a number of cathepsin L-like proteases that are proposed to be involved in feeding, migration, and immune evasion by the parasite. To date, six full cDNA sequences encoding cathepsin L preproproteins have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::da9efc6026bea6c71a07ac1a2b4b1949
http://europepmc.org/abstract/med/11206078

A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance.

Autor: Beesley NJ; Veterinary Parasitology, Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Cwiklinski K; Veterinary Parasitology, Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Allen K; Veterinary Parasitology, Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Hoyle RC; Veterinary Parasitology, Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Spithill TW; Department of Animal, Plant and Soil Sciences and Centre for AgriBioscience, La Trobe University, Bundoora, Australia., La Course EJ; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Williams DJL; Veterinary Parasitology, Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Paterson S; Centre for Genomic Research, Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Hodgkinson JE; Veterinary Parasitology, Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.

Publikováno v: PLoS pathogens [PLoS Pathog] 2023 Jan 26; Vol. 19 (1), pp. e1011081. Date of Electronic Publication: 2023 Jan 26 (Print Publication: 2023).

Evaluation of Immunogenicity and Efficacy of Fasciola hepatica Tetraspanin 2 (TSP2) Fused to E. coli Heat-Labile Enterotoxin B Subunit LTB Adjuvant Following Intranasal Vaccination of Cattle.

Autor: Zerna G; Department of Animal, Plant and Soil Sciences and Centre for AgriBioscience, La Trobe University, Bundoora, VIC 3083, Australia., Rathinasamy VA; Department of Animal, Plant and Soil Sciences and Centre for AgriBioscience, La Trobe University, Bundoora, VIC 3083, Australia., Toet H; Department of Animal, Plant and Soil Sciences and Centre for AgriBioscience, La Trobe University, Bundoora, VIC 3083, Australia., Anderson G; Intensive Livestock, Fisheries & Aquaculture Research, Development & Extension, Department of Agriculture and Fisheries, Dutton Park, QLD 4102, Australia., Dempster R; Virbac (Australia) Pty Ltd., Milperra, NSW 2214, Australia., Spithill TW; Department of Animal, Plant and Soil Sciences and Centre for AgriBioscience, La Trobe University, Bundoora, VIC 3083, Australia., Beddoe T; Department of Animal, Plant and Soil Sciences and Centre for AgriBioscience, La Trobe University, Bundoora, VIC 3083, Australia.

Publikováno v: Vaccines [Vaccines (Basel)] 2021 Oct 20; Vol. 9 (11). Date of Electronic Publication: 2021 Oct 20.

Current Status for Controlling the Overlooked Caprine Fasciolosis.

Autor: Zerna G; Department of Animal, Plant and Soil Sciences and Centre for AgriBioscience, La Trobe University, Bundoora, Victoria 3083, Australia., Spithill TW; Department of Animal, Plant and Soil Sciences and Centre for AgriBioscience, La Trobe University, Bundoora, Victoria 3083, Australia., Beddoe T; Department of Animal, Plant and Soil Sciences and Centre for AgriBioscience, La Trobe University, Bundoora, Victoria 3083, Australia.

Publikováno v: Animals : an open access journal from MDPI [Animals (Basel)] 2021 Jun 18; Vol. 11 (6). Date of Electronic Publication: 2021 Jun 18.

Towards understanding the liver fluke transmission dynamics on farms: Detection of liver fluke transmitting snail and liver fluke-specific environmental DNA in water samples from an irrigated dairy farm in Southeast Australia.

Autor: Rathinasamy V; Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, Vic, Australia; Centre for AgriBioscience, La Trobe University, Bundoora, Vic, Australia., Tran L; Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, Vic, Australia; Centre for AgriBioscience, La Trobe University, Bundoora, Vic, Australia., Swan J; Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, Vic, Australia; Centre for AgriBioscience, La Trobe University, Bundoora, Vic, Australia., Kelley J; Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, Vic, Australia; Centre for AgriBioscience, La Trobe University, Bundoora, Vic, Australia., Hosking C; Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, Vic, Australia; Centre for AgriBioscience, La Trobe University, Bundoora, Vic, Australia., Williamson G; Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, Vic, Australia; Centre for AgriBioscience, La Trobe University, Bundoora, Vic, Australia., Knowles M; Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, Vic, Australia; Centre for AgriBioscience, La Trobe University, Bundoora, Vic, Australia., Elliott T; Invetus, Armidale Research Centre, Armidale, New South Wales, Australia., Rawlin G; Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, Vic, Australia; Centre for AgriBioscience, La Trobe University, Bundoora, Vic, Australia; Department of Jobs, Precincts and Regions, Bundoora, Vic, Australia., Spithill TW; Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, Vic, Australia; Centre for AgriBioscience, La Trobe University, Bundoora, Vic, Australia. Electronic address: t.spithill@latrobe.edu.au., Beddoe T; Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, Vic, Australia; Centre for AgriBioscience, La Trobe University, Bundoora, Vic, Australia. Electronic address: T.beddoe@latrobe.edu.au.

Publikováno v: Veterinary parasitology [Vet Parasitol] 2021 Mar; Vol. 291, pp. 109373. Date of Electronic Publication: 2021 Feb 02.