Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tuyana B. Malankhanova"'
Autor:
Elena V. Grigor'eva, Anastasia A. Malakhova, Diana A. Sorogina, Sofia V. Pavlova, Tuyana B. Malankhanova, Natalia Yu. Abramycheva, Sergey A. Klyushnikov, Sergey N. Illarioshkin, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 63, Iss , Pp 102868- (2022)
Huntington's disease (HD) is a hereditary autosomal dominant neurodegenerative disease caused by the polyglutamine stretch expansion in the huntingtin (HTT) protein. In HD, dysregulation of multiple cellular processes occurs, resulting in the death o
Externí odkaz:
https://doaj.org/article/9857262fec844cbd82b18c42cd467eba
Autor:
Elena V. Grigor’eva, Alena E. Kopytova, Elena S. Yarkova, Sophia V. Pavlova, Diana A. Sorogina, Anastasia A. Malakhova, Tuyana B. Malankhanova, Galina V. Baydakova, Ekaterina Y. Zakharova, Sergey P. Medvedev, Sofia N. Pchelina, Suren M. Zakian
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4437 (2023)
GBA variants increase the risk of Parkinson’s disease (PD) by 10 times. The GBA gene encodes the lysosomal enzyme glucocerebrosidase (GCase). The p.N370S substitution causes a violation of the enzyme conformation, which affects its stability in the
Externí odkaz:
https://doaj.org/article/365091594fc848809889675d20533582
Publikováno v:
Biomedicines, Vol 9, Iss 8, p 960 (2021)
The development of cell models of human diseases based on induced pluripotent stem cells (iPSCs) and a cell therapy approach based on differentiated iPSC derivatives has provided a powerful stimulus in modern biomedical research development. Moreover
Externí odkaz:
https://doaj.org/article/cb28674900f4436ea3e47eba9c9a7cbb
Autor:
Ksenia N Morozova, Lyubov A Suldina, Tuyana B Malankhanova, Elena V Grigor'eva, Suren M Zakian, Elena Kiseleva, Anastasia A Malakhova
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204735 (2018)
Modeling of neurodegenerative diseases in vitro holds great promise for biomedical research. Human cell lines harboring a mutations in disease-causing genes are thought to recapitulate early stages of the development an inherited disease. Modern geno
Externí odkaz:
https://doaj.org/article/17ccde2e1369434f962ba49b85febfec