ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Autor: Richard de Reuver, Evelien Dierick, Bartosz Wiernicki, Katrien Staes, Leen Seys, Ellen De Meester, Tuur Muyldermans, Alexander Botzki, Bart N. Lambrecht, Filip Van Nieuwerburgh, Peter Vandenabeele, Jonathan Maelfait

Publikováno v: Cell Reports, Vol 36, Iss 6, Pp 109500- (2021)

Summary: Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS). ADAR1 converts adenosines into inosines within dsRNA. This process called A

Externí odkaz: https://doaj.org/article/d7a40c1bf3b343a8b89e57477a8835c9

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Autor: Ellen De Meester, Alexander Botzki, Leen J M Seys, Peter Vandenabeele, Filip Van Nieuwerburgh, Tuur Muyldermans, Jonathan Maelfait, Bart N. Lambrecht, Evelien Dierick, Bartosz Wiernicki, Katrien Staes, Richard de Reuver

Publikováno v: Cell Reports, Vol 36, Iss 6, Pp 109500-(2021)
Cell Reports, 36(6):109500. Cell Press
CELL REPORTS

Summary: Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS). ADAR1 converts adenosines into inosines within dsRNA. This process called A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67227824facd3f1ec08aff363d515a37
https://doi.org/10.1016/j.celrep.2021.109500

A framework to assess the quality and impact of bioinformatics training across ELIXIR

Autor: Eija Korpelainen, Allegra Via, Marko Vidak, Brane Leskošek, Lee Larcombe, Louisa J. Bellis, Mateusz Kuzak, Loredana Le Pera, Patricia M. Palagi, Paula Martinez, Celia W.G. van Gelder, Sarah L. Morgan, Tuur Muyldermans, Jessica M. Lindvall, Gabriella Rustici, Kim T. Gurwitz, Hedi Peterson, Alexander Botzki, Roland Krause, Fotis Psomopoulos, Victoria Dominguez Del Angel, Balint L. Balint, Ståle Nygård, Diana Marek, Eva Alloza, Daniel Wibberg, Pedro Fernandes, Prakash Singh Gaur, Jure Dimec, Vojtech Spiwok

Publikováno v: PLoS Computational Biology
PLoS Computational Biology, Public Library of Science, 2020, 16 (7), pp.e1007976. ⟨10.1371/journal.pcbi.1007976⟩
PLOS computational biology (Online) 16 (2020). doi:10.1371/journal.pcbi.1007976
info:cnr-pdr/source/autori:Kim T. Gurwitz1, Prakash Singh Gaur2, Louisa J. Bellis1, Lee Larcombe3, Eva Alloza4, Balint Laszlo Balint5, Alexander Botzki6, Jure Dimec7, Victoria Dominguez del Angel8, Pedro L. Fernandes9, Eija Korpelainen10, Roland Krause11, Mateusz Kuzak12, Loredana Le Pera13, Brane Leskos?ek7, Jessica M. Lindvall14, Diana Marek15, Paula A. Martinez6, Tuur Muyldermans6, Ståle Nygård16, Patricia M. Palagi15, Hedi Peterson17, Fotis Psomopoulos18, Vojtech Spiwok19, Celia W. G. van Gelder12, Allegra Via20, Marko Vidak7, Daniel Wibberg21, Sarah L. Morgan2, Gabriella Rustici1*/titolo:A framework to assess the quality and impact of bioinformatics training across ELIXIR/doi:10.1371%2Fjournal.pcbi.1007976/rivista:PLOS computational biology (Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:16
PLoS computational biology, vol. 16, no. 7, pp. e1007976
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PLoS Computational Biology, Vol 16, Iss 7, p e1007976 (2020)
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ELIXIR is a pan-European intergovernmental organisation for life science that aims to coordinate bioinformatics resources in a single infrastructure across Europe; bioinformatics training is central to its strategy, which aims to develop a training c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad6decd27e6e5883e7325d46ecb73c0
https://hdl.handle.net/2117/331402