Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tuula Lähteenmäki"'
Publikováno v:
European Journal of Pharmacology. 399:75-84
beta-Adrenoceptor agonists, nitric oxide (NO), and NO donors have been shown to mediate their effects through large conductance Ca(2+)-activated K(+) (BK(Ca)) channels. The mechanism of the synergistic effect of the beta(2)-adrenoceptor agonist, salb
Autor:
Timo Vaskonen, Heikki Vapaatalo, R Nevala, J Ahonen, A Soots, Heikki Karppanen, Eero Mervaala, Tuula Lähteenmäki, Leena Krogerus
Publikováno v:
Blood Pressure. 9:162-168
The cardiovascular and renal pathophysiology associated with chronic renal allograft rejection under triple drug immunosuppressive treatment was studied using a recently developed model (Brown Norway (BN) rats) in a 6-week experiment. Renal transplan
Autor:
Juha Laakso, Riitta Korpela, Tuula Lähteenmäki, Heikki Vapaatalo, Leena Seppo, Matti J. Tikkanen, Hannu Vanhanen
Publikováno v:
University of Helsinki
Low-density lipoprotein (LDL) activates a number of processes involved in atherogenesis and vasoconstriction. Evidence suggests that oxidation increases the atherogenicity of LDL. We investigated the effects of oxidized LDL (ox-LDL) on cytotoxicity,
Autor:
Matti J. Tikkanen, Riitta Korpela, E. Solatunturi, Tuula Lähteenmäki, Kirsi Karjala, Heikki Vapaatalo, Juha Laakso, Jari J. Lilja, L Seppo
Publikováno v:
European Journal of Clinical Nutrition. 53:802-807
Objective: To study, if there are differences in the fatty acid composition of low‐density lipoprotein (LDL) in people eating three different long‐standing habitual diets: vegetarian, high fish intake, or high saturated fat (milk fat) diet as a c
Autor:
Eero Mervaala, Heikki Karppanen, Tuula Lähteenmäki, Heikki Vapaatalo, Markus Lassila, Leena Krogerus, Timo Vaskonen
Publikováno v:
Blood Pressure. 8:49-56
Cyclosporine A (CsA)-induced hypertension has been shown to be dependent on the level of dietary salt. The present study assessed the role of the renin-angiotensin system in the development of CsA-induced hypertension and nephrotoxicity in spontaneou
Publikováno v:
British Journal of Pharmacology. 125:402-408
1 The effects of oxatriazole-type (GEA 3162 and GEA 5624) nitric oxide (NO) donors on mitogenesis and proliferation were studied in vascular smooth muscle cell (VSMC) culture. The effects of the GEA-compounds were compared with well-known NO-donors 3
Publikováno v:
Biochemical Pharmacology. 45:1251-1259
To study the mechanism of centrilobular damage developing in the centrilobular region after high doses of acetaminophen (APAP), its metabolism and toxicity were compared in periportal and perivenous hepatocytes isolated by digitonin/collagenase perfu
Autor:
Riitta Korpela, L Seppo, Tuula Lähteenmäki, Heikki Vapaatalo, Hannu Vanhanen, Matti J. Tikkanen
Publikováno v:
European journal of clinical nutrition. 59(11)
To clarify whether supplementation of vitamin E can alter the low density lipoprotein (LDL) oxidation properties and thereby affect endothelial cell function and prostacyclin production in smokers compared to nonsmokers on diets rich in fish in a pil
Autor:
Tuula Lähteenmäki, E. Solatunturi, Riitta Korpela, Heikki Vapaatalo, Kirsi Karjala, Matti J. Tikkanen, Juha Laakso
Publikováno v:
Life sciences. 63(12)
The effects were studied of native, partially-oxidized and totally-oxidized human low-density lipoprotein (LDL) on the proliferation of cultured rat aortic smooth muscle cells (VSMC), measured as an altered DNA synthesis. The LDL was obtained from th
Autor:
Lena Malmberg, Heikki Vapaatalo, Hans-Jürgen Mest, Ilkka Pörsti, Terttu-Liisa Teräväinen, Kirsi Karjala, Ilari Paakkari, Eero Mervaala, Tuula Lähteenmäki, Heikki Karppanen
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 356(1)
The influence of common salt (NaCl) and a novel potassium-, magnesium-, and L-lysine-enriched mineral salt on the cardiovascular and renal effects of the selective imidazoline I1-receptor agonist moxonidine was examined in spontaneously hypertensive